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Hereditary Melanoma and Dysplastic Nevus Syndrome

  • Chapter
Familial and Hereditary Tumors

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 136))

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Abstract

The rapid and continuing increase of incidence of malignant melanoma, especially in developed countries, renders this disease one of the major challenges for oncologists in the future. Melanoma is also of extreme interest in genetic epidemiology; in the introductory chapter, this was defined, in its essence, as the study of the interaction between genes and environmental factors in the etiology and pathogenesis of a given disease. About 10% of all malignant melanomas (MM) have a genetic component; moreover, there is no doubt that environmental factors (sunlight exposure) are also of major importance in their development. We are probably not far from the reality in hypothesizing that a more detailed investigation on the interaction between hereditary predisposition to melanoma (which has now been linked to specific chromosomal loci) and some environmental agents (which can induce highly selective genetic changes) might represent the key passage to the comprehension of this disease.

Within the past half century, the population has been exposed to an astronomical number of chemical agents, but more importantly, the recent development of leisure time outdoor sports activities through mass production of inexpensive equipment and apparel has led to a significantly unprecedented large amount of sunlight exposure which starts as early in life as the first decade of life. These exposures are sudden, multiple and excessive. They occur not only in summer but, due to modern transportation, also in the winter. Thus, patients with atypical moles on their trunk are having a hitherto not encountered human experience of sunlight exposure. R. M. Fusaro H. T. Lynch (1985)

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Authors and Affiliations

  1. Istituto di Patologia Medica Policlinico, Università degli Studi di Modena, Via del Pozzo, 71, 41100, Modena, Italy

    Prof. Dr. M. Ponz de Leon

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  1. Prof. Dr. M. Ponz de Leon
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© 1994 Springer-Verlag Berlin Heidelberg

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de Leon, M.P. (1994). Hereditary Melanoma and Dysplastic Nevus Syndrome. In: Familial and Hereditary Tumors. Recent Results in Cancer Research, vol 136. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85076-9_9

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  • DOI: https://doi.org/10.1007/978-3-642-85076-9_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85078-3

  • Online ISBN: 978-3-642-85076-9

  • eBook Packages: Springer Book Archive

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