Advertisement

Hypercalcemia Associated with Hematologic Malignancies

  • A. Grauer
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 137)

Abstract

The estimated annual incidence rate of hypercalcemia of malignancy is about 150 new cases per million population per year (Mundy et al. 1980). It is likely to affect 20%–40% of patients with malignancies during the course of their disease. The incidence of hypercalcemia of malignancy varies between 0.07% in a population-based study of one million inhabitants (Mundy et al. 1980) and 1.1% in a large epidemiological study of hospital in- and outpatients performed at a major cancer hospital (Vassilopoulou-Sellin et al. 1993).

Keywords

Multiple Myeloma Chronic Lymphatic Leukemia PTHrP Gene Parathyroid Hormone Related Protein Osteoclast Activate Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adams JS, Fernandez M, Gacad MA, Gill PS, Endres DB, Rasheed S, Singer FS (1989) Vitamin D metabolite-mediated hypercalcemia and hypercalciuria patients with AIDS-and non-AIDS-associated lymphoma. Blood 73:235–239PubMedGoogle Scholar
  2. Blayney DW, Jaffe ES, Blattner WA, Cossman J, Robert GM, Longo DL, Bunn P Jr, Gallo RC (1983) The human T-cell leukemia/lymphoma virus associated with American adult T-cell leukemia/lymphoma. Blood 62:401–405PubMedGoogle Scholar
  3. Breslau NA, McGuire JL, Zerwekh JE, Frenkel EP, Pak CY (1984) Hypercalcemia associated with increased serum calcitriol levels in three patients with lymphoma. Ann Intern Med 100:1–6PubMedGoogle Scholar
  4. Bunn P Jr, Schechter GP, Jaffe E, Blayney D, Young RC, Matthews MJ, Blattner W, Bvoder S, Robert GM, Gallo RC (1983) Clinical course of retrovirus-associated adult T-cell lymphoma in the United States. N Engl J Med 309:257–264PubMedCrossRefGoogle Scholar
  5. Canellos GP (1974) Hypercalcemia in malignant lymphoma and leukemia. Ann NY Acad Sci 230:240–246PubMedCrossRefGoogle Scholar
  6. Catovsky D, Greaves MF, Rose M, Galton DA, Goolden AW, McCluskey DR, White JM, Lampert I, Bourikas G, Ireland R, Brownell AI, Bridges JM, Blattner WA, Gallo RC (1982) Adult T-cell lymphoma-leukaemia in Blacks from the West Indies. Lancet 1:639–643PubMedCrossRefGoogle Scholar
  7. Cohn SL, Morgan ER, Mallette LE (1987) The spectrum of metabolic bone disease in lymphoblastic leukemia. Cancer 59:346–350PubMedCrossRefGoogle Scholar
  8. Davies M, Mawer EB, Hayes ME, Lumb GA (1985) Abnormal vitamin D metabolism in Hodgkin’s lymphoma. Lancet 1:1186–1188PubMedCrossRefGoogle Scholar
  9. Dazai Y, Katoh I, Hara Y, Yoshida R, Kurihara K (1991) Two cases of adult T-cell leukemia associated with acute pancreatitis due to hypercalcemia. Am J Med 90:251–254PubMedGoogle Scholar
  10. Dune BGM, Salmon SE, Mundy GR (1981) Relation of osteoclast activating factor production to the extent of bone disease in multiple myeloma. Br J Haematol 47:21–30CrossRefGoogle Scholar
  11. Garrett IR, Dune BG, Nedwin GE, Gillespie A, Bringman T, Sabatini M, Bertolini DR, Mundy GR (1987) Production of lymphotoxin, a bone-resorbing cytokine, by cultured human myeloma cells. N Engl J Med 317:526–532PubMedCrossRefGoogle Scholar
  12. Hennemann HH, Hastka J, Lengfelder E, Pfiester P, Bonatz K (1987) Hypercalcemias in chronic lymphatic leukemias and other non-Hodgkin’s lymphomas. Klin Wochenschr 65:791–797PubMedCrossRefGoogle Scholar
  13. Ikeda K, Okazaki R, Inoue D, Ogata E, Matsumoto T (1993) Transcription of the gene for parathyroid hormone-related peptide from the human is activated through a cAMP-dependent pathway by prostaglandin El in HTLV-I-infected T cells. J Biol Chem 268:1174–1179PubMedGoogle Scholar
  14. Ishibashi K, Kodama M, Hanada S, Arima T (1992) Tumor necrosis factor beta and hypercalcemia. Leuk Lymphoma 7:409–417PubMedCrossRefGoogle Scholar
  15. Johnston SR, Hammond PJ (1992) Elevated serum parathyroid hormone related protein and 1, 25-dihydroxycholecalciferol in hypercalcaemia associated with adult T-cell leukaemia-lymphoma. Postgrad Med J 68:753–755PubMedCrossRefGoogle Scholar
  16. Kabakow B, Mines MF, King FH (1957) Hypercalcemia in Hodgkin’s disease. N Engl J Med 256:59–62PubMedCrossRefGoogle Scholar
  17. Kyle RA (1989) Monoclonal gammopathies and the kidney. Annu Rev Med 40:53–60PubMedCrossRefGoogle Scholar
  18. Martin TJ, Grill V (1992) Hypercalcemia in cancer. J Steroid Biochem Mol Biol 43:123–129PubMedCrossRefGoogle Scholar
  19. Maruyama H, Kawano K, Uno H, Matsuoka H, Yamashita R, Tamaki N, Ishizaki J, Maeda K, Tsuda K (1992) Acute lymphocytic leukemia (LI) preceded by hypercalcemia. Rinsho Ketsueki 33:514–519PubMedGoogle Scholar
  20. Matsuda K, Yamamoto N, Kaneko N, Iwashi M, Hashimoto S, Araki K (1990) Hypercalcemia and adult T-cell leukemia (letter). Lancet 335:1032PubMedCrossRefGoogle Scholar
  21. Mosely JM, Danks JA, Grill V, Lister TA, Horton MA (1991) Immunocytochemical demonstration of PTHrP protein in neoplastic tissue of HTLV-1 positive human adult T-cell leukemia/lymphoma: implications for the mechanism of hypercalcemia. Br J Cancer 64:745–748CrossRefGoogle Scholar
  22. Motokura T, Fukumoto S, Matsumoto T, Takahashi S, Fujita A, Yamashita T, Igarashi T, Ogata E (1989) Parathyroid hormone-related protein in adult T-cell leukemia-lymphoma. Ann Intern Med 111:484–488PubMedGoogle Scholar
  23. Mudde AH, van den Berg H, Boshuis PG, Breedveld FC, Markusse HM, Kluin PM, Bijvoet OL, Papapoulos SE (1987) Ectopic production of 1,25-dihydroxyvitamin D by B-cell lymphoma as a cause of hypercalcemia. Cancer 59:1543–1546PubMedCrossRefGoogle Scholar
  24. Mundy GR (1988) Hypercalcemia of malignancy revisited. J Clin Invest 82:1–6PubMedCrossRefGoogle Scholar
  25. Mundy GR, Martin TJ (1982) The hypercalcemia of malignancy: pathogenesis and management. Metabolism 31:1247–1277PubMedCrossRefGoogle Scholar
  26. Mundy GR, Raisz LG, Cooper RA, Schlechter GP, Salmon SE (1974) Evidence for the secretion of an osteoclast stimulating factor in myeloma. N Engl J Med 291:1041–1046PubMedCrossRefGoogle Scholar
  27. Mundy GR, Cove DH, Fisken R (1980) Primary hyperparathyroidism: changes in the pattern of clinical presentation. Lancet 1:1317–1320PubMedCrossRefGoogle Scholar
  28. Nakamura Y, Bando H, Shintani Y, Yokogoshi Y, Saito S (1992) Serum parathyroid hormone-related protein concentrations in patients with hematologic malignancies or solid tumors. Acta Endocrinol (Copenh) 127:324–330Google Scholar
  29. Norby K, Vikrot O (1975) Hypercalcemia in chronic lymphatic leukemia. Scand J Haematol 15:132–138CrossRefGoogle Scholar
  30. Rosenthal N, Insogna KL, Godsall JW, Smaldone L, Waldron JA, Stewart AF (1985) Elevations in circulating 1,25-dihydroxyvitamin D in three patients with lymphoma-associated hypercalcemia. J Clin Endocrinol Metab 60:29–33PubMedCrossRefGoogle Scholar
  31. Sato K, Fujii Y, Kasono K, Ozawa M, Imamura H, Kanaji Y, Kuroxawa H, Tsushima T, Shizume K (1989) Parathyroid hormone related protein and interleukin 1-alpha synergistically stimulate bone resorption in vitro and increase the serum calcium concentration in vivo. Endocrinology 124:2172–2178PubMedCrossRefGoogle Scholar
  32. Schaefer K, Saupe J, Pauls A, von Herrath D (1986) Hypercalcemia and elevated serum 1,25-dihydroxyvitamin D3 in a patient with Hodgkin’s lymphoma. Klin Wochenschr 64:89–91PubMedCrossRefGoogle Scholar
  33. Senba M, Kawai K (1991) Metastatic calcification due to hypercalcemia in adult T-cell leukemia-lymphoma (ATLL). Zentralbl Pathol 137:341–345PubMedGoogle Scholar
  34. Spiegel A, Greene M, Magrath I, Balow J, Marx S, Auerbach GD (1978) Hypercalcemia with suppressed parathyroid hormone in Burkitt’s lymphoma. Am J Med 64:691–702PubMedCrossRefGoogle Scholar
  35. Todo S, Imashuku S, Inoda H, Yamanaka H, Hibi S, Tsunamoto K, Esumi N, Fujiwara F, Shimizu Y, Morioka Y (1987) Hypercalcemia in a case of childhood acute lymphoblastic leukemia. Jpn J Clin Oncol 17:357–362PubMedGoogle Scholar
  36. Vassilopoulou-Sellin R, Newman BM, Taylor SH, Guinée VF (1993) Incidence of hpercalcemia in patients with malignancy referred to a comprehensive cancer center. Cancer 71:1309–1312PubMedCrossRefGoogle Scholar
  37. Watanabe T, Yamaguchi K, Takatsuki K, Osame M, Yoshida M (1990) Constitutive expression of parathyroid hormone-related protein gene in human T cell leukemia virus type 1 (HTLV-1) carriers and adult T cell leukemia patients that can be transactivated by HTLV-1 tax gene. J Exp Med 172:759–765PubMedCrossRefGoogle Scholar
  38. Yoneda T, Nakai M, Moriyama K, Scott L, Ida N, Kunitomo T, Mundy GR (1993) Neutralizing antibodies to human interleukin 6 reverse hypercalcemia associated with a human squamous carcinoma. Cancer Res 53:737–740PubMedGoogle Scholar
  39. Zaloga GP, Eil C, Medberry CA (1985) Humoral hypercalcemia in Hodgkin’s disease: association with elevated 1,25-dihydroxycholecalciferol levels and subperiosteal bone resorption. Arch Intern Med 145:155–157PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • A. Grauer
    • 1
  1. 1.Department of Internal Medicine I — Endocrinology and MetabolismUniversity of HeidelbergHeidelbergGermany

Personalised recommendations