Poisoning with Class I and IV Antiarrhythmic Agents

  • A. Jaeger
  • P. Sauder
  • J. Kopferschmitt
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine 1994 book series (YEARBOOK, volume 1994)


Antiarrhythmic agents are classified into 4 groups according to their electrophy-siological effects on the action potential of myocardial cells [1]. Among the different classes, the drugs of classes I and IV are of particular interest in intensive care: their toxicity is dose-related and they may induce life-threatening complications, especially severe hemodynamic disturbances. Moreover, these two classes are still expanding and include several groups of drugs which have specific pharmacological and toxic effects [2–7]. Class I antiarrhythmic agents are widely used in the treatment of supraventricular and ventricular arrhythmias. Class IV antiarrhythmic agents are used in the treatment of supraventricular dysrhythmias, angina pectoris and hypertension. Acute poisonings by these drugs are relatively rare but severe; the mortality rate is about 10–15% [5, 6]. Toxicity of these agents requires immediate evaluation and in many cases intensive care management.


Calcium Channel Blocker Antiarrhythmic Agent Toxic Dose Cardiotoxic Effect Severe Poisoning 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • A. Jaeger
  • P. Sauder
  • J. Kopferschmitt

There are no affiliations available

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