Regional versus Global Indicators of Tissue Oxygenation
Tissue hypoxia is one of the important factors in the pathogenesis of multiple organ failure (MOF) in patients with septic shock . Hence we need a method which enables us to estimate the adequacy of tissue oxygenation in ICU patients. One method to prove the adequacy of tissue oxygenation is the O2 flux test. The fundamental principle is to increase oxygen delivery (DO2) and subsequently measure O2 consumption (VO2) . An increase in VO2 by more than 10% is interpreted as an improvement of previously inadequate tissue oxygenation . Therefore, the lack of a rise in VO2 after increasing DO2 is considered to be an indicator of adequate tissue oxygenation [4, 5]. However, the O2 flux test has some limitations: changes in body temperature or a restless patient, and the calorigenic effects of the infused catecholamines could also lead to increases in VO2 which, in these cases, is not an indicator of preexisting tissue O2 debt.
KeywordsSeptic Shock Multiple Organ Failure Tissue Oxygenation Hepatic Blood Flow Global Indicator
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