Abstract
l-Tyrosine ethyl ester [2] (2.30 g, 11 mmol) is dissolved, with gentle warming, in dry tetrahydrofurane (5 ml). The solution is cooled to room temperature and N-benzyloxycarbonyl-S-benzyl-l-cysteine cyan methyl ester [1, 3] (3.84 g, 10 mmol) is added followed by a catalytic amount (0.03 ml) of acetic acid. The reaction is allowed to proceed at room temperature for two days. The solvent is removed in vacuo, the residue dissolved in ethyl acetate (100 ml) and the solution extracted with 0.5 N KHCO3 (50 ml), water (50 ml), 0.5 N HC1 (50 ml) and water (50 ml), dried over anhydrous Na2SO4 and evaporated to dryness in vacuo.
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References
Harrison D, Smith ACB J Chem Soc 1960: 2157; cf. page 200
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© 1994 Springer-Verlag Berlin Heidelberg
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Bodanszky, M., Bodanszky, A. (1994). Coupling with Active Esters. In: The Practice of Peptide Synthesis. Springer Lab Manual. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85055-4_10
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DOI: https://doi.org/10.1007/978-3-642-85055-4_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-57505-4
Online ISBN: 978-3-642-85055-4
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