Skip to main content
SpringerLink
Log in

Human Neuroblastoma: Amplification of the N-myc Oncogene and Loss of a Putative Cancer-Preventing Gene on Chromosome 1p

  • Conference paper
Molecular Neuro-oncology and Its Impact on the Clinical Management of Brain Tumors

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 135))

Abstract

The nervous system is the most common site for the development of solid neoplasms in childhood. Neuroblastoma represents a tumor developing at peripheral sites from primitive neuroectodermal cells derived from the neural crests. It very often has a rapidly progressive clinical course. Many advances have been made in understanding the genesis and biology of this tumor which have been translated into better clinical management; however, little improvement in survival rates has been achieved, at least for the large group of patients who have metastatic tumor.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alitalo K, Schwab M (1986) Oncogene amplification in tumor cells. Adv Cancer Res 47: 235

    Article  PubMed  CAS  Google Scholar 

  • Alitalo K, Schwab M, Lin CC, Varmus H, Bishop JM (1983) Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. Proc Natl Acad Sci USA 80: 1707

    Article  PubMed  CAS  Google Scholar 

  • Amler LC, Schwab M (1989) Amplified N-myc in human neuroblastoma cells is often arranged as clustered tandem repeats of differently recombined DNA. Molec Cell Biol 9: 4903

    PubMed  CAS  Google Scholar 

  • Amler LC, Schwab M (1992) Multiple amplicons of discrete sizes encompassing N-myc in neuroblastoma cells evolve through differential recombination from a large precursor DNA. Oncogene 7: 807

    PubMed  CAS  Google Scholar 

  • Bartram CR, Berthold F (1987) Amplification and expression of the N-myc gene in neuroblastoma. Eur J Pediatr 146: 162

    Article  PubMed  CAS  Google Scholar 

  • Beckwith JB and Perrin EV (1963) In situ neuroblastomas: a contribution to the natural history of neural crest tumors. Am J Pathol 43:1089

    PubMed  CAS  Google Scholar 

  • Berthold F (1990) Overview Biology of neuroblastoma. In: Neuroblastoma: Tumor Biology and Therapy. Pochadly, Tebbi, (eds) CRC Press Inc, Boca Raton, p 1

    Google Scholar 

  • Blackwood EM, Eisenman RN (1991) Max: A helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science 251: 1211

    Article  PubMed  CAS  Google Scholar 

  • Brodeur G, Seeger RC, Schwab M, Varmus HE, Bishop JM (1984) Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Sience 224: 1121

    Article  CAS  Google Scholar 

  • Brodeur GM, Green AA, Hayes FA, Williams KG, Williams DL, Tsiatis AA (1981) Cytogenetic features of human neuroblastomas and cell lines. Cancer Res 41: 4678

    PubMed  CAS  Google Scholar 

  • Carlsen NLT, Christiansen IJ, Schroeder H, Bro PV, Hesselberg K, Jensen KB, Nielsen KH (1986) Prognostic value of different staging systems in neuroblastomas and completeness of tumour exision. Arch Die Child 61: 832

    Article  CAS  Google Scholar 

  • Cohn SL, Herst CV, Maurer HS, Rosen ST (1987) N-myc amplification in an infant with stage IV-s neuroblastoma. J Clin Oncol 5:1441

    PubMed  CAS  Google Scholar 

  • Cox D, Yuncken C, Spriggs A (1965) Minute chromatin bodies in malignant tumours of childhood. Lancet 2: 55

    Article  Google Scholar 

  • Douglass EC, Rowe ST, Valentine M, Parham DM, Berkow R, Bowman WP, Maurer HM (1991) Variant translocations of chromosome 13 in alveolar rhabdomyosarcoma. Genes, Chromosomes & Cancer 3: 480

    Article  CAS  Google Scholar 

  • Evans AE, D’Angio GB, Randolph J (1971) A proposed staging for children with neuroblastoma. Cancer 27: 374

    Article  PubMed  CAS  Google Scholar 

  • Fearon ER, Hamilton SH, Vogelstein B (1987) Clonal analysis of human colorectal tumours. Science 238: 193

    Article  PubMed  CAS  Google Scholar 

  • Flejter WL, Li FP, Antman KH, Testa JR (1989) Recurring loss involving chromosomes 1, 3 and 22 in malignant mesothelioma: Possible sites of tumor suppressor genes. Genes, Chromosomes and Cancer 1: 148

    Article  CAS  Google Scholar 

  • Fong CT, Dracopoli NC, White PS, Merril PT, Griffith RC, Housman DE, Brodeur GM (1989) Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: Correlation with N-myc amplification. Proc Natl Acad Sci USA 86: 3753

    Article  PubMed  CAS  Google Scholar 

  • Fuller G, Bigner S (1992) Amplified cellular oncogenes in neoplasms of the central nervous system. Mut Res 276: 299

    CAS  Google Scholar 

  • Garson JA, McIntyre PG, Kemshead JT (1985) N-myc amplification in malignant astrocytoma. The Lancet 8457: 718

    Article  Google Scholar 

  • Genuardi M, Tshihira H, Anderson DE, Saunders GF (1989) Distal deletion of chromosome 1p in ductal carcinoma of the breast. Amer J Hum Genet 45: 73

    PubMed  CAS  Google Scholar 

  • Hamann U, Wenzel A, Frank R, Schwab M (1991) The MYCN protein of human neuroblastoma cells is phosphorylated by casein kinase II in the central region and at serine 367. Oncogene 6: 1745

    PubMed  CAS  Google Scholar 

  • Harnett PR, Kearsley JH, Hayward NK, Dracopoli NC, Kefford RF (1991) Loss of allelic heterozygosity on distal chromosome 1p in Merkel Cell Carcinom. Cancer Genet Cytogenet 54: 109

    Article  PubMed  CAS  Google Scholar 

  • Hasegawa R, Tatematsu M, Imaida K et al. (1982) Neuroblastoma in situ. Acta Pathol Jpn 32: 537

    PubMed  CAS  Google Scholar 

  • Kato GJ, Barrett J, Villa-Garcia M, Dang CV (1990) An amino-terminal c-myc domain required for neoplastic transformation activities transcription. Mol Cell Biol 10: 5914

    PubMed  CAS  Google Scholar 

  • Kohl NE, Kanda N, Schreck RR, Bruns G, Latt SA, Gilbert F, Alt FW (1983) Transposition and amplification of oncogene-related sequences in human neuroblastomas. Cell 35: 359

    Article  PubMed  CAS  Google Scholar 

  • Koufos A, Hansen MF, Copeland NG, Jenkins NA, Lampkin BC, Cavanee WK (1985) Loss of heterozygosity in three embryonal tumors suggest a common pathogenetic mechanism. Nature 316: 330

    Article  PubMed  CAS  Google Scholar 

  • Kramer S, Meadows AT, Jarrett P, Evans AE (1983) Incidence of childhood cancer: experience of a decade in a population-based registry. J Natl Cancers Inst 70: 49

    CAS  Google Scholar 

  • Laureys G, Speleman F, Opdenakker G, Benoit Y, Leroy J (1990) Constitutional translocation t(1;17)(p36;g12–21) in a patient with neuroblastoma. Genes, Chromosomes and Cancer 2: 252

    Article  CAS  Google Scholar 

  • Lee WH, Murphree AL, Benedict WF (1984) Expression and amplification of the N-myc gene in primary retinoblastoma. Nature 309: 458

    Article  PubMed  CAS  Google Scholar 

  • Leister I, Weith A, Brüderlein S, Cziepluch C, Schlag P, Schwab M (1990) Human colorectal cancer: high frequency of deletions at chromosome 1p35. Cancer Res 50: 7232

    PubMed  CAS  Google Scholar 

  • Lindström E, Salford LG, Heim S, Mandahl N, Strömblad S, Brun A, Mitelman F (1991) Trisomy 7 and sex chromosome loss need not be representative of tumor parenchyma cells in malignant glioma. Genes, Chromosomes & Cancer 3: 474

    Article  Google Scholar 

  • Mäkelä, TP, Saksela K, Alitalo K (1989) Two N-myc polypeptides with distinct amino termini encoded by the second and third exons of the gene. Mol Cell Biol 9: 1545

    PubMed  Google Scholar 

  • Mäkelä TP, Koskinen PJ, Västrik I, Alitalo K (1992) Alternative forms of Max as enhancers of suppressors of myc-ras cotransformation. Science 256: 373

    Article  PubMed  Google Scholar 

  • Martinsson T, Weith A, Cziepluch C, Schwab M (1989) Chromosome 1 deletions in human neuroblastomas: Generation and fine mapping of microclones from the distal 1p region. Genes, Chromosomes and Cancer 1: 67

    Article  CAS  Google Scholar 

  • Michaelis J, Kaatsch P (1986) Cooperative documentation of childhood malignancies in the FRG. System design and five-year results. Monogr Paediatr 18: 56

    Google Scholar 

  • Nakagawara A, Ikeda K, Tsuda T, Higashi K (1988) Biological characteristics of NMYC amplified neuroblastomas in patients over one year of age. In: Advances in neuroblastoma research; Evans, D’Angio, Seeger (eds). Alan R Liss, Inc. New York, p 31

    Google Scholar 

  • Nau M, Brooks B, Carney D, Gazdar A, Batey J, Sausville E, Minna J (1986) Human small-cell lung cancers show amplification and expression of the N-myc gene. Proc Natl Acad Sci USA 83: 1092

    Article  PubMed  CAS  Google Scholar 

  • O’Rourke RW, Miller CW, Kato GJ, Simon KJ, Chen D-L, Dang CV, Koeffler HP (1990) A potential transcriptional activation element in the p53 protein. Oncogene 5: 1829

    PubMed  Google Scholar 

  • Rustgi AK, Dyson N, Bernards R (1991) Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product. Nature 352: 541

    Article  PubMed  CAS  Google Scholar 

  • Schwab M (1988) The MYC-box oncogenes. In: The Oncogene Handbook; Reddy, Skalka, Curran (eds) Elsevier Science Publishers BV, p 381

    Google Scholar 

  • Schwab M, Amler LC (1990) Amplification of cellular oncogenes: A predictor of clinical outcome in human cancer. Genes, Chromosomes and Cancer 1: 180

    Google Scholar 

  • Schwab M, Alitalo K, Klempnauer KH, Varmus HE, Bishop JM, Gilbert F, Brodeur G, Goldstein M, Trent J (1983) Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblasoma cell lines and a neuroblastoma tumor. Nature 305: 245

    Article  PubMed  CAS  Google Scholar 

  • Schwab M, Alitalo K, Varmus KH, Bishop JM, George D (1983) A cellular oncogene (c-Ki-ras) is amplified, overexpressed, and located within karyotypic abnormalities in mouse adrenocortical tumor cells. Nature 303: 497

    Article  PubMed  CAS  Google Scholar 

  • Schwab M, Varmus HE, Bishop JM, Grzeschik KH, Naylor S, Sakaguchi A, Brodeur G, Trent J (1984) Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc. Nature 308: 288

    Article  PubMed  CAS  Google Scholar 

  • Seeger RC, Brodeur GM, Sather H, Dalton A, Siegel SE, Wong KY, Hammond D (1985) Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N Engl J Med 313: 1111

    Article  PubMed  CAS  Google Scholar 

  • Simon D, Knowles B, Weith A (1991) Abnormalities of chromosome 1 and loss of heterozygosity on 1p in primary hepatomas. Oncogene 6: 765

    PubMed  CAS  Google Scholar 

  • Suzuki T, Mugishima H, Fujisawa T, Okumi M, Okabe I, Yokota J, Terada M (1991) Loss of heterozygosity on chromosome 14 in neuroblastoma. In: Advances in Neuroblastoma Reserach; Evans AE, D’Angio GJ, Knudson Jr AG, Seeger RC (eds) Wiley-Liss, Inc, p135

    Google Scholar 

  • Takayama H, Suzuki T, Mugishima H, Fujisawa T, Ookuni M, Schwab M, Gehring M, Nakamura Y, Sugimura T, Terada M, Yokota J (1992) Deletion mapping of chromosomes 14q and 1p in human neuroblastoma. Oncogene 7: 1185

    PubMed  CAS  Google Scholar 

  • Tonini GP, Verdona G, de Bernardi B, Sansone R, Massimo L, Cornaglia-Ferraris P (1987) N-myc oncogene amplification in a patient with IV-s neuroblastoma. Am J Pediatr Hematol Oncol 9:8

    Article  Google Scholar 

  • Weith A, Martinsson T, Cziepluch C, Brüderlein S, Amler LC, Berthold F, Schwab M (1989) Neuroblastoma consensus deletion maps to chromosome Ip36.1–2. Genes, Chromosomes and Cancer 1: 159

    Article  CAS  Google Scholar 

  • Wenzel A, Cziepluch C, Hamann U, Schürmann J, Schwab M (1991) The N-Myc oncoprotein is associated in vivo with the phosphoprotein Max(p20/22) in human neuroblastoma cells. EMBO J 10: 3703

    PubMed  CAS  Google Scholar 

  • Weston K, Bishop JM (1989) Transcriptional activation by the v-myb oncogene and its cellular progenitor, c-myb. Cell 58: 85

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Cytogenetics, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    M. Schwab

Authors
  1. M. Schwab
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut für Neuropathologie, Universitätskliniken Bonn, Sigmund-Freud-Straße 25, 53105, Bonn, Germany

    O. D. Wiestler

  2. Neurologische Universitätsklinik, Sigmund-Freud-Straße 25, 53105, Bonn, Germany

    U. Schlegel  & J. Schramm  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Schwab, M. (1994). Human Neuroblastoma: Amplification of the N-myc Oncogene and Loss of a Putative Cancer-Preventing Gene on Chromosome 1p. In: Wiestler, O.D., Schlegel, U., Schramm, J. (eds) Molecular Neuro-oncology and Its Impact on the Clinical Management of Brain Tumors. Recent Results in Cancer Research, vol 135. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85039-4_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-85039-4_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85041-7

  • Online ISBN: 978-3-642-85039-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation