Interstitial Implant Radiosurgery of Brain Tumors: Radiobiology, Indications, and Results

  • C. B. Ostertag
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 135)


The discovery of radium by Marie and Pierre Curie in 1898 was followed promptly by the clinical application of this radioisotope in the treatment of various cancers. Alexander Graham Bell suggested in 1903: “There is no reason why a tiny fragment of radium sealed-up in a fine glass tube should not be inserted into the very heart of the cancer, thus acting directly on the diseased material” [2]. This statement accurately describes the irradiation technique that was later known as brachytherapy (greek for radiation therapy in short range, as opposed to teletherapy). The technique is based on the principle of selectively irradiating a tumour while protecting the healthy surroun­ding brain from radiation energy. The amount of radiation reaching normal tissue varies inversely with the square of the distance from the implanted radioactive source.


Brain Metastasis Pilocytic Astrocytoma Whole Brain Radiation Therapy Vasogenic Edema Cerebral Metastasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • C. B. Ostertag
    • 1
  1. 1.Abteilung Stereotaktische NeurochirurgieNeurochirurgische UniversitätsklinikFreiburgGermany

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