Sepsis pp 61-85 | Cite as

Bacterial Exotoxins and Sepsis

  • W. Seeger
  • H. Schütte
  • F. Grimminger
  • N. Suttorp
  • S. Bhakdi
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 18)


Researchers engaged in the study of septic shock pathogenesis generally regard this syndrome to be the consequence of detrimental endotoxin effects in the host organism. This is understandable since causal relationships are firmly established between the action of endotoxin on various inflammatory competent cells. Surprisingly, proteinaceous microbial toxins have received only little attention as potentially important instigators of systemic inflammation and multiorgan dysfunction. Our present discussion will focus on some of these widespread, yet less well known, bacterial exotoxins that exert direct effects on target cells.


Platelet Activate Factor Vascular Leakage Rabbit Lung Endothelial Barrier Function Pulmonary Artery Endothelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • W. Seeger
  • H. Schütte
  • F. Grimminger
  • N. Suttorp
  • S. Bhakdi

There are no affiliations available

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