Bacterial Exotoxins and Sepsis
Researchers engaged in the study of septic shock pathogenesis generally regard this syndrome to be the consequence of detrimental endotoxin effects in the host organism. This is understandable since causal relationships are firmly established between the action of endotoxin on various inflammatory competent cells. Surprisingly, proteinaceous microbial toxins have received only little attention as potentially important instigators of systemic inflammation and multiorgan dysfunction. Our present discussion will focus on some of these widespread, yet less well known, bacterial exotoxins that exert direct effects on target cells.
KeywordsPlatelet Activate Factor Vascular Leakage Rabbit Lung Endothelial Barrier Function Pulmonary Artery Endothelial Cell
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