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N-Acetylcysteine in Sepsis

  • Chapter
Sepsis

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 18))

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Abstract

Sepsis, septic shock and multiple organ dysfunction syndrome are characterized by progressive inadequate tissue perfusion and maldistribution of blood flow [1]. Endothelium-derived relaxing factor is considered to be important in maintaining nutrive blood flow [2]. Increased oxygen radicals known to be generated in large amounts during endotoxic shock and sepsis [3–8] inactivate nitric oxide or 5-nitrocysteine, which account for the vasodilator action of endothelium-derived relaxing factor [9–12]. A constitutive nitric oxide synthase is present in endothelial cells [9], certain neurons [3, 14], endocardium [15], myocardium [16] and platelets [17, 18].

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Authors
  1. C. Spies
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  2. K. Reinhart
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Editors and Affiliations

  1. Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller-Universität Jena, Bachstraße 18, 07740, Jena, Germany

    Konrad Reinhart

  2. Klinik für Anästhesiologie und operative Intensivmedizin, Universitätsklinikum Steglitz der FU Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Klaus Eyrich

  3. Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University, Medical Center, P. O. Box 12000, 91120, Jerusalem, Israel

    Charles Sprung (Direktor) (Direktor)

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© 1994 Springer-Verlag Berlin Heidelberg

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Spies, C., Reinhart, K. (1994). N-Acetylcysteine in Sepsis. In: Reinhart, K., Eyrich, K., Sprung, C. (eds) Sepsis. Update in Intensive Care and Emergency Medicine, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85036-3_34

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  • DOI: https://doi.org/10.1007/978-3-642-85036-3_34

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  • Print ISBN: 978-3-642-85038-7

  • Online ISBN: 978-3-642-85036-3

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