Skip to main content
SpringerLink
Log in
Book cover

Sepsis pp 16–22Cite as

Clinical Manifestations and Prognostic Indicators in Sepsis

  • Chapter

  • 145 Accesses

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 18))

Abstract

Sepsis can be defined as the systemic response to the presence in the body of microorganisms of their toxic products. Previous clinical studies have required in vitro laboratory growth of the organisms to confirm the diagnosis of sepsis. The septic syndrome is defined by specific clinical criteria and has a significant mortality rate in addition to other sequelae commonly associated with sepsis.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. McCabe WR (1973) Gram negative bacteremia: disease-a-month. Year Book Medical Publishers, Chicago.

    Google Scholar 

  2. Sheagren JH (1986) Shock syndromes related to sepsis. Cecil textbook of medicine. Saunders, Philadelphia, pp 1473–1477.

    Google Scholar 

  3. McCabe WR, Treadwell TL, Maria AD (1983) Pathophysiology of bacteremia. Am J Med 75:7–18.

    Article  PubMed  CAS  Google Scholar 

  4. National Heart, Lung, and Blood Institute (1979) Extracorporeal support for respiratory insufficiency: Collaborative study. National Heart, Lung, and Blood Institute, Washington DC.

    Google Scholar 

  5. Goldfarb RD, Tambolini W, Wiener SM et al (1983) Canine left ventricular performance during LD50 endotoxemia. Am J Physiol 244: H370–H377.

    PubMed  CAS  Google Scholar 

  6. Kreger BEW, Craven DE, McCabe WR (1980) Gram-negative bacteremia: IV. Reevaluation of clinical features and treatment in 612 patients. Am J Med 68:344–355.

    Article  PubMed  CAS  Google Scholar 

  7. McCabe WR (1973) Serum complement levels in bacteremia due to gram negative organisms. N Engl J Med 288:21–23.

    Article  PubMed  CAS  Google Scholar 

  8. Winslow EJ, Loeb HS, Rahimtoola SH et al (1973) Hemodynamic studies and results of therapy in 50 patients with bacteremic shock. Am J Med 54:421–432.

    Article  PubMed  CAS  Google Scholar 

  9. Hook EW, Horton CA, Schaberg DR (1983) Failure of intensive care unit support to influence mortality from pneumococcal bacteremia. J Am Med Assoc 249:1055–1057.

    Article  Google Scholar 

  10. Bone RC, Fisher CJ, Clemmer TP et al (1989) The sepsis syndrome: a valid clinical entity. Crit Care Med 17:389–393.

    Article  PubMed  CAS  Google Scholar 

  11. Parker MM, Parillo JE (1983) Hemodynamics and pathogenesis. J Am Med Assoc 250:3324–3327.

    Article  CAS  Google Scholar 

  12. Shubin H, Weil MH (1976) Bacterial shock. J Am Med Assoc 235:421–424.

    Article  CAS  Google Scholar 

  13. Abraham E, Shoemaker WC, Bland RD et al (1983) Plasma fibronectin in medical ICU patients. Crit Care Med 11:799–803.

    Article  PubMed  CAS  Google Scholar 

  14. Halushka PV, Reines HD, Barrow SE et al (1985) Elevated 6-keto-prostaglandin Fla in patients in septic shock. Crit Care Med 13:451–453.

    Article  PubMed  CAS  Google Scholar 

  15. Reines HD, Cook JA, Halushka PV et al (1982) Plasma thromboxane concentrations are raised in patients dying with septic shock. Lancet 2:174–175.

    Article  PubMed  CAS  Google Scholar 

  16. Fourrier F, Chopin C, Wallaert B et al (1985) Compared evolution of plasma fibronectin and angio-converting enzye levels in septic ARDS. Chest 87:191–195.

    Article  PubMed  CAS  Google Scholar 

  17. O’Connell MT, Becker DM, Steele BW et al (1984) Plasma fibronectin in medical ICU patients. Crit CareMed 12:479–482.

    Article  Google Scholar 

  18. Zinner SH, McCabe WR (1976) Effects of IgM and IgG antibody in patients with bacteremia due to gram-negative bacilli. J Infect Dis 133:37–45.

    Article  PubMed  CAS  Google Scholar 

  19. Pollack M, Huang AI, Prescott PK et al (1984) Enhanced survival in pseudomonas aeruginosa septicemia associated with high levels of circulating antibody to E. coli endotoxin core. J Clin Invest 72:1874–1881.

    Article  Google Scholar 

  20. Girotti MJ, Menkes E, MacDonald JWD et al (1984) Effects of immunization on cardiopulmonary alterations of gram-negative endotoxemia. J Appl Physiol 56:582–589.

    PubMed  CAS  Google Scholar 

  21. Ziegler EJ, McCutchan JA, Fierer J et al (1982) Treatment of gram-negative bacteremia and shock with human antiserum to a mutant E. coli. N Engl J Med 307:1225–1230.

    Article  PubMed  CAS  Google Scholar 

  22. Lachman E, Pitsoe SB, Gaffin SL (1984) Anti-lipopolysaccharide immunotherapy in management of septic shock of obstetric and gynecological origin. Lancet 1:981–983.

    Article  PubMed  CAS  Google Scholar 

  23. Moore RD, Smith CR, Lietman PS (1984) The association of aminoglycoside plasma levels with mortality in patients with gram-negative bacteremia. J Infect Dis 149:443–448.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. R. C. Bone
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Klinik für Anästhesiologie und Intensivtherapie, Klinikum der Friedrich Schiller-Universität Jena, Bachstraße 18, 07740, Jena, Germany

    Konrad Reinhart

  2. Klinik für Anästhesiologie und operative Intensivmedizin, Universitätsklinikum Steglitz der FU Berlin, Hindenburgdamm 30, 12200, Berlin, Germany

    Klaus Eyrich

  3. Department of Anesthesiology and Critical Care Medicine, Hadassah Hebrew University, Medical Center, P. O. Box 12000, 91120, Jerusalem, Israel

    Charles Sprung (Direktor) (Direktor)

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Bone, R.C. (1994). Clinical Manifestations and Prognostic Indicators in Sepsis. In: Reinhart, K., Eyrich, K., Sprung, C. (eds) Sepsis. Update in Intensive Care and Emergency Medicine, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85036-3_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-85036-3_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85038-7

  • Online ISBN: 978-3-642-85036-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation