Sepsis-Related Problems in Pediatric Patients
The physiologic changes that constitute the process of sepsis are induced by microbial agents during bloodstream infection or by the toxic products of pathogens that are released from sites of focal infection. This process involves changes generated by the immune system and controlled by hormones, cytokines and enzymes. There are many host and microbial factors that may unfavorably influence this complex immune response. Underlying diseases with immunosuppressive effects, surgery, state of nutrition, immunomodulatory therapy and site of infection increase the risk for development of invasive disease and determine the extent of the immune response [1–3]. However, sepsis in the pediatric population occurs very frequently in previously healthy children. Also, in comparison with adults, the sepsis is more overwhelming. Mortality is mainly confined to the first 48 h of the disease. In children vs adults, different pathogens are involved and the quality and quantity of the immune response depend on the age of the child. These differences are probably caused by developmental aspects of several organ systems and may have special consequences for management and therapy.
KeywordsSeptic Shock Fresh Freeze Plasma Neonatal Sepsis Neisseria Meningitidis Experimental Sepsis
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