Skip to main content
SpringerLink
Log in

Sicherheit und antidepressive Wirksamkeit von spezifischen Serotonin-Wiederaufnahmehemmern (SSRIs)

  • Conference paper
Depression

Zusammenfassung

Selektive Serotoninwiederaufnahmehemmer (SSRIs) stellen eine neue Klasse von Antidepressiva dar, die in den letzten 10 Jahren Eingang in die Psychiatrie gefunden haben. Diese Substanzen wurden mit dem Ziel entwickelt, im Vergleich zu trizyklischen oder tetrazyklischen Antidepressiva weniger Nebenwirkungen bzw. Komplikationen hervorzurufen. Darüber hinaus wurde für Subgruppen depressiver Erkrankungen, z.B. gehemmte bzw. somatisierte Depressionen, eine spezifische Wirksamkeit angestrebt.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Amin MM, Anath JV, Colemans BS et al. (1984) Fluvoxamine, antidepressant effect confirmed in a placebo controlled international study. Clin Neuropharmacol 7 (Suppl 1): 312–319

    Google Scholar 

  • Beasley CM, Dornseif BE, Bosomworth JC et al. (1991) Fluoxetine and suicide a meta-analysis of controlled trials of treatment for depression. Br Med J 303: 685–692

    Article  Google Scholar 

  • Bech P (1988) A review of the antidepressant properties of serotonin reuptake inhibitors. In: Gastpar M, Wakelin JS (eds) Selective 5-HT reuptake inhibitors. Novel or Commonplace agents? Karger, Basel, pp 58–69

    Google Scholar 

  • Bulusu I, Alderson M (1984) Suicides 1950–1982. Office of population censuses and Survey HMSO. Population Trends 35: 11–13

    Google Scholar 

  • Cassano GB, Conti L, Massimetti G et al. (1986) Use of a standardized documentation system ( BLIPS/BPD) in the conduct of a multicenter international trial comparing fluvoxamine, imipramine and placebo. Psychopharmacol Bull 22: 52–58

    PubMed  CAS  Google Scholar 

  • Coleman BS, Block BA (1982) Fluvoxamine-maleate. A serotonergic antidepressant: A comparison with chlorimipramine. Neurol Psychopharmacol Biol Psychiatr 6: 475–478

    Article  CAS  Google Scholar 

  • Danish University Antidepressant Group (1986) Citalopram, clinical effect profile in comparison with clomipramine. A controlled multicentre study. Psychopharmacol 90: 131–299

    Google Scholar 

  • Danish University Antidepressant Group (1990) Paroxetine: A selective serotonin reuptake inhibitor showing better tolerance, but weaker antidepressant effect Wirksamkeit von spezifischen Serotonin-Wiederaufnahmehemmern than clomipramine in a controlled multicentre study. J Affective Disord 18: 284–299

    Google Scholar 

  • Dominguez RA, Goldstein BJ, Jacobson AG, Steinbook RM (1985) A doubleblind placebo-controlled study for fluvoxamine and imipramine in depression. J Clin Psychiatry 46: 84–87

    PubMed  CAS  Google Scholar 

  • Feighner J, Boyer WF, Meredith C, Hendrickson GG (1989) A placebo-controlled inpatients comparison of fluvoxamine maleate and imipramine in major depression. Int Clin Psychopharmacol 4: 239–244

    Article  PubMed  CAS  Google Scholar 

  • Fuger J, Zinner HJ, Kasper S, Möller HJ (1992) Efficacy of the new generation antidepressants - a statistical metaanalysis. Pharmacopsychiatry, in press

    Google Scholar 

  • Ginestet D et al. (1989) Etude de la fluocetine dans le traitement des depressions endogènes et des mélancolies. Int Clin Psychopharmacol (Suppl 1 ): 37–40

    Google Scholar 

  • Goodman-Gilman et al. (1990) The pharmacological basis of therapeutics, VIII Ed. Pergamon, New York, p 412

    Google Scholar 

  • Guelfi JD, Dreyfus JF, Pichot P (1983) The GEP. A double-blind controlled clinical trial of comparing fluvoxamine with imipramine. Br J Clin Pharmacol 15 (Suppl 3): 411–417

    Google Scholar 

  • Guze SB, Robins E (1970) Suicide among primary affective disorders. Br J Psychiatry 117: 437–438

    Article  PubMed  CAS  Google Scholar 

  • Hagnell O, Lanke J, Rorsman B (1981) Suicide rates in the Lundbystudy; mental illness as a risk factor for suicide. Neuropsychology 7: 248–253

    CAS  Google Scholar 

  • Henry JA (1989) A fatal toxicity index for antidepressant poisoning. Acta Psychiatr Scand 80: 37–45

    Article  Google Scholar 

  • Itil TM, Shrivastava RK, Mukherjee S, Coleman BS, Michael ST (1983) A doubleblind placebo-controlled study of fluvoxamine and imipramine in out-patients with primary depression. Br J Clin Pharmacol 15 (Suppl 3): 433–438

    Google Scholar 

  • Jonghe de F, Swinkels JA (1992) The safety of antidepressants. Drugs 43 (Suppl 2): 40–47

    Article  PubMed  Google Scholar 

  • Kasper S, Voll G, Vieira A, Kick H (1990) Response to total sleep deprivation before and during treatment with fluvoxamine of maprotiline in patients with major depression - results of a double-blind study. Pharmacopsychiatry 23: 135–142

    Article  PubMed  CAS  Google Scholar 

  • Kasper S, Fuger J, Möller HJ (1992a) Comparative efficacy of antidepressants. Drugs 43 (Suppl 2): 11–23

    Article  PubMed  Google Scholar 

  • Kasper S, Dötsch M, Vieira A, Möller HJ (1992b) Plasma levels of fluvoxamine and maprotiline and clinical response in major depression. Eur Neurpsychopharmacol 3: 13–21

    Article  Google Scholar 

  • Laakman G, Blaschke D, Engel R, Schwarz A (1988) Fluoxetine vs amitriptyline in the treatment of depressed outpatients. Br J Psychiatry 153 (Suppl 3): 64–68

    Google Scholar 

  • Lapierre YD, Browne M, Horn E et al. (1987) Treatment of major effective disorder with fluvoxamine. J Clin Psychiatry 48: 65–68

    PubMed  CAS  Google Scholar 

  • Mendlewicz J (1992) Efficacy of fluvoxamine in severe depression. Drugs 43 (Suppl 2): 32–39

    Article  PubMed  Google Scholar 

  • Milne RJ, Goa KL (1991) Citalopram. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness. Drugs 41: 450–477

    Article  PubMed  CAS  Google Scholar 

  • Möller HJ, Berzewski H, Gonzales N et al. (1991) A double-blind, multicenter study of paroxetine and amitriptyline in depressed outpatients. Presented at the 5th World Congress of Biological Psychiatry. Florence, June, 9–14

    Google Scholar 

  • Möller HJ, Fuger J, Kasper S (1993) Statische Metaanalyse der Wirksamkeit neuerer Antidepressiva. In: Riederer P, Laux G, Pöldinger W (Hrsg) Neuropsychopharmaka, Bd 3. Springer, Wien New York (im Druck)

    Google Scholar 

  • Montgomery SA, McAuley R, Rani SJ, Roy D, Montgomery D (1981) A doubleblind comparison of zimelidine and amitriptyline in endogenous depression. Acta Psychiatr Scand (Suppl 290 ) 63: 314–327

    Article  CAS  Google Scholar 

  • Montgomery SA, Pinder RM (1987) Do some antidepressants promote suicide? Psychopharmacology 92: 265–266

    Article  PubMed  CAS  Google Scholar 

  • Montgomery SA, Lambert MT, Lynch SPJ (1988) The risk of suicide with antidepressants. Int Clin Psychopharmacol 3 (Suppl 2): 15–24

    PubMed  Google Scholar 

  • Muijen M, Roy D, Silverstone T, Mehmet A, Christie M (1988) A comparative clinical trial of fluoxetine, mianserin and placebo with depressed outpatients. Acta Psychiatr Scand 78: 384–390

    Article  PubMed  CAS  Google Scholar 

  • Norton KRW, Sierling LI, Bhat AV, Rao B, Paykel ES (1984) A doubleblind comparison of fluvoxamine, imipramine and placebo in depressed patients. J Affective Disord 7: 297–308

    Article  CAS  Google Scholar 

  • Ottevanger E (1991) The efficacy of fluvoxamine in patients with severe depression. Br J Clin Res 2: 125–132

    Google Scholar 

  • van Praag HM, Kahn R, Asnis GM et al. (1987) Therapeutic indications for serotonin potentiating compounds: a hypotheses. Biol Psychiatry 22: 205–212

    Article  PubMed  Google Scholar 

  • Potter WZ, Karoum F, Linnoila M (1984) Common mechanism of action of biochemically „specific” antidepressants. Prog Neuropsychopharmacol Biol Psychiatry 8: 153–161

    Article  PubMed  CAS  Google Scholar 

  • Reimher FW, Byerley WF, Ward MF, Lebegue BJ, Wender PH (1988) Sertraline, a selective inhibitor of serotonin uptake, for the treatment of outpatients with major depressive disorder. Psychopharmacol Bull 24: 200–205

    Google Scholar 

  • Rickeis K, Schweizer E (1990) Clinical overview of serotonin reuptake inhibitors. J Clin Psychiatry 51: 9–12

    Google Scholar 

  • Rouillon F, Phillips R, Serrurier E, Ansart E, Gerard MJ (1989) Prophylactic efficacy of maprotiline on relapses of unipolar depression. Encephale 15: 527–534

    PubMed  CAS  Google Scholar 

  • Starkey IR, Lawson AAH (1980) Psychiatric aspect of acute poisoning with tricyclic and related antidepressants. A ten year review. Scott Med J 25: 303–308

    PubMed  CAS  Google Scholar 

  • Teicher MH, Glod C, Cole JO (1990) Emergence of intense suicidal preoccupation during fluoxetine treatment. Am J Psychiatry 147: 207–210

    PubMed  CAS  Google Scholar 

  • Wagner W, Piekkenpol B, Gray TE, Viaskamp H, Essers H (1992) Review of fluvoxamine safety database. Drugs 43 (Suppl 2): 48–52

    Article  PubMed  Google Scholar 

  • Wakelin J (1988) The role of serotonin in depression and suicide. Adv Biol Psychiatry 17: 70–83

    Google Scholar 

Download references

Authors
  1. Siegfried Kasper
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gereon Höflich
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hans-Peter Scholl
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hans-Jürgen Möller
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Psychiatrische Klinik mit Poliklinik, Universität Erlangen-Nürnberg, Schwabachanlage 6, 91054, Erlangen, Germany

    Eberhard Lungerhausen (Direktor), Peter Joraschky (Leiter der Abteilung Psychosomatische Medizin und Psychotherapie) & Arnd Barocka (Ltd. Oberarzt) (Direktor),  (Leiter der Abteilung Psychosomatische Medizin und Psychotherapie) &  (Ltd. Oberarzt)

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Kasper, S., Höflich, G., Scholl, HP., Möller, HJ. (1993). Sicherheit und antidepressive Wirksamkeit von spezifischen Serotonin-Wiederaufnahmehemmern (SSRIs). In: Lungerhausen, E., Joraschky, P., Barocka, A. (eds) Depression. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85010-3_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-85010-3_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-57133-9

  • Online ISBN: 978-3-642-85010-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation