Abstract
The prefrontal cortex has been considered to be essential for initiative and reasoning behaviour in humans, and delayed and discriminative movement tasks in monkeys (see Fulton 1949; Rosenkilde 1979; Luria 1966; Fuster 1989). We have studied, in monkey experiments, the functional role of prefrontal cortex in the organization and control of conditioned hand movements in response to visual stimuli (see Sasaki 1985). Several parts of the prefrontal cortex, especially the prearcuate area, are very active in initiating simple reaction-time hand movements in response to visual stimuli and are important in processes of learning the movement (Sasaki and Gemba 1982). The wide areas of the prefrontal cortex together with the premotor cortex were found to be continuously excited between warning and imperative stimuli, and to produce contingent negative variation (CNV) (Sasaki et al. 1990; Gemba et al. 1990).
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References
Brooks VB (1984) Cerebellar functions in motor control. Human Neurobiol 2:251–260
Brooks VB, Kozlovskaya IB, Atkin A, Horvath FE, Uno M (1973) Effects of cooling dentate nucleus on tracking-task performance in monkeys. J Neurophysiol 36:974–995
Fulton JF (1949) Physiology of the nervous system. Oxford University Press, London New York
Fuster JM (1989) The prefrontal cortex. Raven Press, New York
Gemba H, Hashimoto S, Sasaki K (1981) Cortical field potentials preceding visually initiated hand movements in the monkey. Exp Brain Res 42:435–441
Gemba H, Sasaki K (1989) Potential related to no-go reaction of go/no-go hand movement task with color discrimination in human. Neurosci Lett 101:263–268
Gemba H, Sasaki K (1990) Potential related to no-go reaction in go/no-go hand movement with discrimination between tone stimuli of different frequencies in the monkey. Brain Res 537:340–344
Gemba H, Sasaki K, Tsujimoto T (1990) Cortical field potentials associated with hand movements triggered by warning and imperative stimuli in the monkey. Neurosci Lett 113:275–280
Goldberg G (1985) Supplementary motor area structure and function: Review and hypotheses. Behav Brain Sci 8:567–616
Hashimoto S, Gemba H, Sasaki K (1979) Analysis of slow cortical potentials preceding selfpaced hand movement in the monkey. Exp Neurol 65:218–229
Jodo E, Kayama Y (1992) Relation of a negative ERP component to response inhibition in a go/no-go task. Electroenceph Clin Neurophysiol 82:477–482
Lamarre Y, Spidalieri G, Chapman CE (1983) A comparison of neuronal discharge recorded in the sensori-motor cortex, parietal cortex and dentate nucleus of the monkey during arm movements triggered by light, sound or somesthetic stimuli. In: Massion J, Paillard J, Schultz W, Wiesendanger M (eds) Neural coding of motor performance. Springer-Verlag, Berlin Heidelberg, pp 140–156
Luria AR (1966) Higher cortical functions in man. Travistock, London
Petrides M (1986) The effect of periarcuate lesions in the monkey on the performance of symmetrically and asymmetrically reinforced visual and auditory go, no-go tasks. J Neurosci 6(7):2054–2063
Rosenkilde CE (1979) Functional heterogeneity of the prefrontal cortex in the monkey: A review. Behav Neur Biol 25:301–345
Sasaki K (1975) Electrophysiological studies on thalamo-cortical projections. In: Mori K (ed) Neurophysiological basis of anesthesia. Little Brown and Company, Boston, pp 1–35
Sasaki K (1979) Cerebro-cerebellar interconnections in cats and monkeys. In: Massion J, Sasaki K (eds) Cerebro-cerebellar interactions. Elsevier/North-Holland Biomedical Press, Amsterdam, pp 105–124
Sasaki K (1985) Cerebro-cerebellar interactions and organization of a fast and stable hand movement: Cerebellar participation in voluntary movement and motor learning. In: Bloedel JR, Dichgans J, Precht W (eds) Cerebellar functions. Springer-Verlag, Berlin, pp 70–85
Sasaki K, Gemba H (1982) Development and change of cortical field potentials during learning processes of visually initiated hand movements in the monkey. Exp Brain Res 48:429–437
Sasaki K, Gemba H (1983) Learning of fast and stable hand movement and cerebro-cerebellar interactions in the monkey. Brain Res 277:41–46
Sasaki K, Gemba H (1984a) Compensatory motor function of the somatosensory cortex for the motor cortex temporarily impaired by cooling in the monkey. Exp Brain Res 55:60–68
Sasaki K, Gemba H (1984b) Compensatory motor function of the somatosensory cortex for dysfunction of the motor cortex following cerebellar hemispherectomy in the monkey. Exp Brain Res 56:532–538
Sasaki K, Gemba H (1986a) Effects of premotor cortex cooling upon visually initiated hand movements in the monkey. Brain Res 374:278–286
Sasaki K, Gemba H (1986b) Electrical activity in the prefrontal cortex specific to no-go reaction of conditioned hand movement with colour discrimination in the monkey. Exp Brain Res 64:603–606
Sasaki K, Gemba H (1986c) Projection from the prefrontal cortex onto the cerebellar hemisphere in the monkey. J Physiol Soc Jap 48:261
Sasaki K, Gemba H (1987a) Effects of cooling the prefrontal and prestriate cortex upon visually initiated hand movements in the monkey. Brain Res 415:362–366
Sasaki K, Gemba H (1987b) Plasticity of cortical function related to voluntary movement: Motor learning and compensation following brain dysfunction. Acta Neurochirurg, Suppl 41:18–28
Sasaki K, Gemba H (1989a) “No-go potential” in the prefrontal cortex of monkeys. In: Basar E, Bullock TH (eds) Brain dynamics, progress and perspective. Springer-Verlag, Heidelberg, pp 290–301
Sasaki K, Gemba H (1989b) Motor programme for voluntary movement in the cerebrocerebellar neuronal circuit. In: Ito M (ed) Neural programming. Japan Scientific Societies Press, Tokyo, pp 67–76
Sasaki K, Gemba H (1993) Prefrontal cortex in the organization and control of voluntary movement. In: Ono T, Squire LR, Raichle ME, Perrett DI, Fukuda M (eds) Brain mechanisms of perception and memory. Oxford University Press, New York, pp 473–496
Sasaki K, Gemba H, Hashimoto S (1981) Premovement slow cortical potentials on self-paced hand movements and thalamocortical and corticocortical responses in the monkey. Exp Neurol 72:41–50
Sasaki K, Gemba H, Mizuno N (1982) Cortical field potentials preceding visually initiated hand movements and cerebellar actions in the monkey. Exp Brain Res 46:29–36
Sasaki K, Gemba H, Tsujimoto T (1989) Suppression of visually initiated hand movement by stimulation of the prefrontal cortex. Brain Res 495:100–107
Sasaki K, Gemba H, Tsujimoto T (1990) Cortical field potential associated with hand movement on warning-imperative visual stimulus and cerebellum in the monkey. Brain Res 519:343–346
Sasaki K, Gemba H, Nambu A, Jinnai K, Yamamoto T, Llinas R (1992a) Cortical activity specific to no-go reaction in go/no-go reaction time hand movement with colour discrimination in monkeys and human subjects. Biomed Res 13, Suppl 1:5–9
Sasaki K, Gemba H, Nambu A, Matsuzaki R (1992b) Localization of no-go activity in human frontal cortex by MEG study. Jap J Physiol 42, Suppl S176, 472
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Sasaki, K., Gemba, H., Nambu, A., Matsuzaki, R. (1994). Activity of the Prefrontal Cortex on No-Go Decision and Motor Suppression. In: Thierry, A.M., Glowinski, J., Goldman-Rakic, P.S., Christen, Y. (eds) Motor and Cognitive Functions of the Prefrontal Cortex. Research and Perspectives in Neurosciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85007-3_10
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DOI: https://doi.org/10.1007/978-3-642-85007-3_10
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