Concomitant Boost-Accelerated, Superfractionated Irradiation for the Treatment of Advanced Carcinomas of the Oral Cavity and Oropharynx
With the trend of organ-preserving cancer management, the treatment of squamous cell carcinomas (SCC) of the upper aerodigestive tract increasingly includes radiotherapy used alone or in combination with surgery. The current standards of maximum locoregional tumor control of more advanced SCC of the oral cavity and oropharynx have been set by surgical resection combined with pre- or postoperative irradiation yielding widely varying control rates depending on tumor site and stage (Wazer et al. 1989; Huang et al. 1992; Parsons et al. 1981; Chu and Fletcher 1973; Million 1979; Dasmahapatra et al. 1986). Similar control rates have been achieved for moderately advanced lesions of the oral cavity using combined external beam and interstitial irradiation (Schmidt-Ullrich et al. 1991a; Mendenhall et al. 1981; Fu et al. 1976; Wang et al. 1983). Based on recent investigation, superfractionated and accelerated irradiation has been applied to the treatment of carcinomas of the oral cavity and oropharynx (Peters et al. 1988; Withers et al. 1988; Wang 1988; Saunders et al. 1989; Million et al. 1985; Horiot et al. 1988; Schmidt-Ullrich et al. 1991b; Ang et al. 1990; Johnson et al. 1992).
KeywordsToxicity Fractionation Oncol Assure Candida
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