Carcinomas of the Oropharynx Treated with Hyperfractionated Radiation Therapy on Radiation Therapy Oncology Group Protocol 8313
Squamous cell carcinomas of the oropharynx are among the sites within the upper aerodigestive tract most consistently treated with radiation therapy. The ability to observe directly the response to radiation therapy and to document local-regional control and failure result in their being excellent sites to investigate modifiers of radiation effects.
KeywordsRadiation Therapy Oncology Group Severe Late Toxicity Radiation Therapy Oncology Group Trial Radiation Therapy Oncology Group Protocol Interfraction Interval
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- Cox JD, Azarnia N et al. (1990a) A randomized phase I/II trial of hyperfractionated radiation therapy with total doses of 60.0 Gy to 79.2 Gy: possible survival benefits with ⩾69.6 Gy in favorable patients with Radiation Therapy Oncology Group stage III non-small-cell lung carcinoma: report of Radiation Therapy Oncology Group 82-11. J Clin Oncol 8: 1543–1555PubMedGoogle Scholar
- Cox JD, Pajak TF et al. (1990b) Dose-response for local control with hyperfractionated radiation therapy in advanced carcinomas of the upper aerodigestive tracts: preliminary report of Radiation Therapy Oncology Group Protocol 83-13. Int J Radiat Oncol Biol Phys 18: 515–521PubMedCrossRefGoogle Scholar
- Cox JD, Pajak TF et al. (1991) ASTRO plenary: interfraction interval is a major determinant of late effects, with hyperfractionated radiation therapy of carcinomas of upper respiratory and digestive tracts: results from Radiation Therapy Oncology Group Protocol 8313. Int J Radiat Oncol Biol Phys 20: 1191–1195PubMedCrossRefGoogle Scholar
- Mantel N (1966) Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chem Rep 5: 163–170Google Scholar
- Pajak TF, Laramore GE. (1991) Elapsed treatment days - a critical item for radiotherapy quality control review in head and neck trials: RTOG report. Int J Radiat Oncol Biol Phys 20: 13–20Google Scholar