Skip to main content
SpringerLink
Log in
Book cover

Peptides in Oncology II pp 115–129Cite as

Bombesin Antagonists: Experimental and Clinical Results

  • Chapter

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 129))

Abstract

Lung cancer is the leading cause of cancer deaths in North America and Western Europe. Despite considerable knowledge of the genetic changes involving protooncogenes and tumor suppressor genes in lung cancer pathogenesis, and significant therapeutic progress achieved during the early 1980s with use of radio- and chemotherapy, overall treatment outcome remains poor for most patients. To design alternative therapeutic strategies in this disease, it is important to work toward the identification of mitogenic factors and a more complete understanding of the signal transduction pathways that stimulate lung cancer cell growth.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aguayo SM, King TE, Kane MA, Sherritt KM, Silvers W, Nett LM, Petty TL, Miller YE (1992) Urinary levels of bombesin-like peptides in asymptomatic cigarette smokers: a potential risk marker for smoking-related diseases. Cancer Res [Suppl] 52: 2727s - 2731s

    CAS  Google Scholar 

  • Alexander RW, Upp JR, Poston GJ, Gupta V, Townsend CM, Thompson JC (1988) Effects of bombesin on growth of human small cell lung carcinoma in vivo. Cancer Res 48: 14391441

    Google Scholar 

  • Anastasi A, Erspamer V, Bucci M (1971) Isolation and structure of bombesin alytesin, two analogous active peptides from the skin of the European amphibians Bombina and Alytes. Experientia 27: 166–167

    Article  PubMed  CAS  Google Scholar 

  • Avis IL, Kovacs TOG, Kasprzyk PG, Treston AM, Bartholonew R, Walsh JH, Cuttita F, Mulshine JL (1991) Preclinical evaluation of an anti-autocrine growth factor monoclonal antibody for treatment of patients with small-cell lung cancer. J Natl Cancer Inst 83:1470 —1476

    Google Scholar 

  • Battey JF, Way JM, Corjay MH, Shapira H, Kusano K, Harkins R, Wu JM, Slattery T, Mann E, Feldmann RI (1991) Molecular cloning of the bombesin/gastrin-releasing peptide receptor from Swiss 3T3 cells. Proc Natl Acad Sci USA 88: 395–399

    Article  PubMed  CAS  Google Scholar 

  • Bepler G, Rotsch M, Jaques G, Haeder M, Heymanns J, Hartogh G, Kiefer P, Havemann K (1988 a) Peptides and growth factors in small cell lung cancer: production, binding sites, and growth effects. J Cancer Res Clin Oncol 114: 235–244

    Article  PubMed  CAS  Google Scholar 

  • Bepler G, Zeymer U, Mahmoud S, Fiskum G, Palszynski E, Rotsch M, Willey J, Koros A, Cuttita F, Moody TW (1988 b) Substance P analogues function as bombesin receptor antagonists and inhibit small cell lung cancer clonal growth. Peptides 9: 1367–1372

    Article  PubMed  CAS  Google Scholar 

  • Brown M, Allen R, Villareal J, Rivier J, Vale W (1978) Bombesin-like activity: radioimmunologic assessment in biological tissues. Life Sci 23: 2721–2726

    Article  PubMed  CAS  Google Scholar 

  • Carney DN, Gazdar AF, Bepler G, Guccion JG, Marangos PJ, Moody TW, Zweig MH, Minna JD (1985) Establishment and identification of small cell lung cancer cell lines having classical and variant features. Cancer Res 45: 2913–2923

    PubMed  CAS  Google Scholar 

  • Carney DN, Cuttita F, Moody TW, Minna JD (1987) Selective stimulation of small cell lung cancer clonal growth by bombesin and gastrin-related peptide. Cancer Res 47:821–825

    Google Scholar 

  • Cirillo DM, Gaudino G, Naldini L, Comoglio PM (1986) Receptor for bombesin withassociated tyrosine kinase activity. Mol Cell Biol 6:4641–4649

    PubMed  CAS  Google Scholar 

  • Coy DH, Jiang NY, Kim SH, Moreau JP, Lin JT, Frucht H, Qian JM, Wang LW, Jensen RT (1991) Covalently cyclized agonist and antagonist analogues of bombesin and related peptides. J Biol Chem 266: 16441–16447

    PubMed  CAS  Google Scholar 

  • Cuttita F, Carney DN, Mulshine J, Moody TW, Fedorko J, Fischler A, Minna JD (1985) Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer. Nature 316: 823–826

    Article  Google Scholar 

  • Cutz E, Chan W, Track NS (1981) Bombesin, calcitonin, and leukenkaphalin immunoreactivity in endocrine cells of human lung. Experientia 37: 765–767

    Article  PubMed  CAS  Google Scholar 

  • Dockray GJ, Vaillant C, Walsh JH (1979) The neuronal origin of bombesin-like immunoreactivity in the rat gastrointestinal tract. Neuroscience 4: 1561–1568

    Article  PubMed  CAS  Google Scholar 

  • Dohlman HG, Caron MG, Lefkowitz RJ (1987) A family of receptors coupled to guanine nucleotide regulatory proteins. Biochem J 26: 2657–2664

    Article  CAS  Google Scholar 

  • Erusalimsky JD, Friedberg I, Rozengurt E (1988) Bombesin, diacylglycerols and phorbol esters rapidly stimulate the phosphorylation of an Mr 80000 protein kinase C substrate in permeabilized 3T3 cells: effect of guanine nucleotides. J Biol Chem 263:19188–19194

    PubMed  CAS  Google Scholar 

  • Ghatei MA, Jung RT, Stevenson JC, Hiiyard CJ, Adrian TC, Lee YC, Christofides ND, Sarson DL, Nashiter K, MacIntyre I, Bloom SR (1982) Bombesin action on gut hormones and calcium in man. J Clin Endocrinol Metab 54: 980–985

    Article  PubMed  CAS  Google Scholar 

  • Giaccone G, Battey J, Gazdar AF, Oie H, Draoui M, Moody TW (1992) Neuromedin B is present in lung cancer cell lines. Cancer Res [Suppl] 52: 2732s - 2736s

    CAS  Google Scholar 

  • Gietzen K, Bai G, Abdallah F (1990) Selective inhibition of proliferation by a novel dihydropyridine derivative with anti-calmodulin activitiy in the mammary tumour cell line ZR-75–1. Med Sci Res 18: 627–629

    CAS  Google Scholar 

  • Heikkila R, Trepel JB, Cuttita F, Neckers LM, Sausville R (1987) Bombesin-related peptides induce calcium mobilization in a subset of human small cell lung cancer cell lines. J Biol Chem 262: 16456–16460

    PubMed  CAS  Google Scholar 

  • Hucho F (1986) The nicotinic acetylcholine receptor and its ion channels. Eur J Biochem 158: 211–226

    Article  PubMed  CAS  Google Scholar 

  • Jensen RT, Jones SW, Folkers K, Gardner JD (1984) A synthetic peptide that is a bombesin receptor antagonist. Nature 309: 61–63

    Article  PubMed  CAS  Google Scholar 

  • Korman LY, Carney DN, Citron ML, Moody TW (1986) Secretin/vasoactive peptide-stimulated secretion of bombesin/gastrin releasing peptide from human small cell carcinoma of the lung. Cancer Res 46: 1214–1218

    PubMed  CAS  Google Scholar 

  • Krane IM, Naylor SL, Helin-Davis D, Chin WW, Spindel ER (1988) Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. J Biol Chem 263:13 317–13 323

    Google Scholar 

  • Kris RM, Hazan R, Villines J, Moody TW, Schlessinger J (1987) Identification of the bombesin receptor on murine and human cells by cross-linking experiments. J Biol Chem 262: 11 215–11220

    Google Scholar 

  • Layton JE, Scanlon DB, Soveny C, Morstyn G (1988) Effects of bombesin antagonists on the growth of small cell lung cancer cells in vitro. Cancer Res 48: 4783–4789

    PubMed  CAS  Google Scholar 

  • Lebacq-Verheyden AM, Kaprzyk PG, Raum MG, Van Wyke Coelingh K, Lebacq JA, Battey JF (1988) Posttranslational processing of endogenous and baculovirus-expressed human gastrin releasing peptide precursor. Mol Cell Biol 8: 3129–3135

    PubMed  CAS  Google Scholar 

  • Luster W, Gropp C, Kern HF, Havemann K (1985) Lung tumor cell lines synthesizing peptide hormones established from tumours of four histological types: characterization of the cell lines and analysis of their peptide hormone production. Br J Cancer 51: 865875

    Google Scholar 

  • Mahmoud S, Staley J, Taylor J, Bogden A, Moreau JP, Coy D, Avis I, Cuttita F, Mulshine JL, Moody TW (1991) [Psi13,14 Leu14]bombesin analogues inhibit growth of small cell lung cancer in vitro and in vivo. Cancer Res 51: 1798–1802

    Google Scholar 

  • McDonald TJ, Nilsson G, Vagne M, Ghatei M, Bloom SR, Mutt V (1978) A gastrin releasing peptide from the porcine non-antral gastric tissue. Gut 19: 767–774

    Article  PubMed  CAS  Google Scholar 

  • McGregor GP, Woodhams PL, O’Shaugnessy D, Ghatei MA, Polak JM, Bloom SR (1982) Developmental changes in bombesin, substance P, somatostatin, and vasoactive intestinal polypeptide in rat brain. Neurosci Lett 28: 21–27

    Article  PubMed  CAS  Google Scholar 

  • Moody TW, Pert CB (1979) Bombesin-like peptides in rat brain. Biochem Biophys Res Commun 90: 7–14

    Article  PubMed  CAS  Google Scholar 

  • Moody TW, Pert CB, Gazdar AF, Carney DN, Minna JD (1981) High levels of intracellular bombesin characterize human small-cell lung carcinoma. Science 214: 1246–1248

    Article  PubMed  CAS  Google Scholar 

  • Moody TW, Murphy A, Mahmoud S, Fiskum G (1987) Bombesin-like peptides elevate cytosolic calcium in small cell lung cancer cells. Biochem Biophys Res Commun 147: 189195

    Google Scholar 

  • Mulshine J, Avis I, Carrasquillo J, Merchant B, Boland C, Perentesis P, Reynolds J, Larson S, Treston A, Scott F, Kasprzyk P, Johnson B, Ihde D, Gazdar A, Cuttita F, Minna JD (1990) Phase I study of an anti gastrin releasing peptide (GRP) monoclonal antibody in patients with lung cancer. Proc Am Assoc Clin Oncol 9: 230 (abstr)

    Google Scholar 

  • Mulshine JL, Shuke N, Daghighian F, Carrasquillo J, Ghosh B, Walsh T, Avis I, Reynolds R, Cuttita F, Larson SM (1992) The correct dose: pharmacologically guided end point for anti-growth factor therapy. Cancer Res [Suppl] 52: 2743s - 2746s

    CAS  Google Scholar 

  • Panula P (1986) Histochemistry and function of bombesin-like peptides. Med Biol 64: 177192

    Google Scholar 

  • Polak JM, Bloom SR, Hobbs S, Solcia E, Pearse AGE (1976) Distribution of bombesin-like peptide in human gastrointestinal tract. Lancet I: 1109–1110

    Google Scholar 

  • Quinn KA, Treston AM, Scott FM, Kaprzyk PG, Avis I, Siegfried JM, Mulshine JL, Cuttita F (1991) Alpha-amidation of peptide hormones in lung cancer. Cancer Cells 3: 504–510

    PubMed  CAS  Google Scholar 

  • Sanders KH, Boer R, Eltze M, Galvan J (1988) Differential vascular and cardiac effects of the enantiomers of three dihydropyridine calcium antagonists, niguldipine, nitrendipine, and felodipine. Arch Pharmacol 338 [Suppl]: R36

    Google Scholar 

  • Sausville EA, Lebacq-Verheyden AM, Spindel ER, Cuttita F, Gazdar AF, Battey JF (1986) Expression of the gastrin-releasing peptide gene in human small cell lung cancer. J Biol Chem 261: 2451–2457

    PubMed  CAS  Google Scholar 

  • Schuller HM (1991) Receptor-mediated mitogenesis signals and lung cancer. Cancer Cells 3: 496–503

    PubMed  CAS  Google Scholar 

  • Schuller HM (1992) Nitrosamine-induced lung carcinogenesis and Ca’ /calmodulin antagonists. Cancer Res [Suppl] 52: 27 23s - 2726s

    Google Scholar 

  • Schuller HM, Correa E, Orloff M, Reznik GK (1990) Successful chemotherapy of experimental neuroendocrine lung tumors in hamsters with an antagonist of Ca’ /calmodulin. Cancer Res 50: 1645–1649

    PubMed  CAS  Google Scholar 

  • Schuller HM, Orloff M, Reznik GK (1991) Antiproliferative effects of the Ca’ /calmodulin antagonist B859–35 and the CaZ+/channel blocker verapamil on human lung cancer cell lines. Carcinogenesis 12: 2301–2303

    Article  PubMed  CAS  Google Scholar 

  • Sethi T, Rozengurt E (1991 a) Multiple neuropeptides stimulate clonal growth of small cell lung cancer: effects of bradykinin, vasopressin, cholecystokinin, galanin, and neurotensin. Cancer Res 51: 3621–3623

    Google Scholar 

  • Sethi T, Rozengurt E (1991 b) Galanin stimulates CaZ+ mobilization, inositol phosphate accumulation, and clonal growth in small cell lung cancer cells. Cancer Res 51: 1674–1679

    Google Scholar 

  • Sethi T, Langdon S, Smyth J, Rozengurt E (1992) Growth of small cell lung cancer cells: stimulation by multiple neuropeptides and inhibition by broad spectrum antagonists in vitro and in vivo. Cancer Res [Suppl] 52: 2737s - 2742s

    CAS  Google Scholar 

  • Sinnet-Smith J, Lehmann W, Rozengurt E (1990) Bombesin receptor in membranes from Swiss 3T3 cells. Biochem J 265: 485–493

    Google Scholar 

  • Spindel ER, Chin WW, Price J, Rees LH, Besser GM, Habener JF (1984) Cloning and characterization of cDNAs encoding human gastrin-releasing peptide. Proc Natl Acad Sci USA 81: 5699–5703

    Article  PubMed  CAS  Google Scholar 

  • Tache Y, Brown M (1982) On the role of bombesin in homeostasis. Trends Neurosci 5: 431433

    Google Scholar 

  • Tamai S, Kameya T, Yamafuchi K, Yanai N, Abe K, Yanaihara N, Yamazaki H, Kegeyama K (1983) Peripheral lung carcinoid tumor producing predominantly gastrin-releasing peptide ( GRP ). Cancer 52: 273–281

    Google Scholar 

  • Trepel JB, Moyer JD, Cuttita F, Frucht H, Coy DH, Natale RB, Mulshine JL, Jensen RT, Sausville EA (1988 a) A novel bombesin receptor antagonist inhibits autocrine signals in a small cell lung carcinoma cell line. Biochem Biophys Res Commun 156: 1383–1389

    Google Scholar 

  • Trepel JB, Moyer JD, Heikkila R, Sausville EA (1988 b) Modulation of bombesin-induced phosphatidylinositol hydrolysis in small-cell lung-cancer cell line. Biochem J 255: 403–410

    Google Scholar 

  • Überall F, Maly K, Egle A, Doppler W, Hofmann T, Grunicke HH (1991) Inhibition of cell proliferation, protein kinase C1 and phorbolester-induced fos expression by the dihydropyridine derivative B859–35. Cancer Res 51: 5821–5825

    PubMed  Google Scholar 

  • Wada E, Way J, Lebacq-Verheyden AM, Battey JF (1990) Neuromedin B and gastrin releasing peptidem RNAs are differentially distributed in the rat nervous system. J Neurosci 10: 2917–2930

    PubMed  CAS  Google Scholar 

  • Wada E, Way J, Shapira H, Kusano K, Lebacq-Verheyden AM, Coy D, Jensen R, Battey J (1991) cDNA cloning, characterization and brain region-specific expression of a neuromedin-B preferring bombesin receptor. Neuron 6: 421–430

    Google Scholar 

  • Weber S, Zuckerman JE, Bostwick DG, Bensch KG, Sikic BI, Raffin TA (1985) Gastrin releasing peptide is a selective mitogen for small cell lung carcinoma in vitro. J Clin Invest 75: 306–309

    Article  PubMed  CAS  Google Scholar 

  • Wharton J, Polak JM, Bloom SR, Ghatei MA, Solcia E, Brown MR, Pearse AGE (1978) Bombesin-like immunoreactivity in the lung. Nature 273: 769–770

    Article  PubMed  CAS  Google Scholar 

  • Willey JC, Lechner JF, Harris CC (1984) Bombesin and the C-terminal tetradecapeptide of gastrin-releasing peptide are growth factors for normal human bronchial cells. Exp Cell Res 153: 245–248

    Article  PubMed  CAS  Google Scholar 

  • Woll PJ, Rozengurt E (1988) [D-ArgI,D-Phes,n-Trp7’9,Leu14]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro. Proc Natl Acad Sci USA 85: 1859–1863

    Google Scholar 

  • Woll PJ, Rozengurt E (1990) A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro. Cancer Res 5: 3968–3973

    Google Scholar 

  • Wood SM, Wood JR, Ghatei MA, Lee YC, O’Shaughnessy D, Bloom SR (1981) Bombesin, somatostatin and neurotensin-like immunoreactivity in bronchial carcinoma. J Clin Endocrinol Metab 53: 1310–1312

    Article  PubMed  CAS  Google Scholar 

  • Yamaguchi K, Abe K, Adachi I, Suzuki M, Kimura S, Kameya T, Yanaihara N (1984) Concomitant production of immunoreactive gastrin-releasing peptide and calcitonin in medullary carcinoma of the thyroid. Metabolism 33: 724–727

    Article  PubMed  CAS  Google Scholar 

  • Zachary I, Rozengurt E (1986) A substance P antagonist also inhibits specific binding and mitogenic effects of vasopressin and bombesin-related peptides in Swiss 3T3 cells. Biochem Biophys Res Commun 137: 135–141

    Article  PubMed  CAS  Google Scholar 

  • Zachary I, Gil J, Lehmann W, Sinnet-Smith J, Rozengurt E (1991) Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation in intact Swiss 3T3 cells. Proc Natl Acad Sci USA 88: 4577–4581

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Innere Klinik und Poliklinik (Tumorforschung) Westdeutsches Tumorzentrum, Universitätsklinikum Essen, Hufelandstraße 55, W-4300, Essen 1, Germany

    J. Schütte & S. Seeber

Authors
  1. J. Schütte
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Seeber
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Klinik für Innere Medizin II: Onkologie — Hämatologie — Endokrinologie — Stoffwechselerkrankungen, Klinikum der Friedrich-Schiller-Universität Jena, Erlanger Allee 101, O-6902, Jena-Lobeda, Germany

    K. Höffken

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Schütte, J., Seeber, S. (1993). Bombesin Antagonists: Experimental and Clinical Results. In: Höffken, K. (eds) Peptides in Oncology II. Recent Results in Cancer Research, vol 129. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84956-5_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-84956-5_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84958-9

  • Online ISBN: 978-3-642-84956-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation