Abstract
The terminal catabolism of most plasma lipoproteins occurs chiefly in the liver. The LDL receptor mediates the removal of apolipoprotein (apo) B-100 containing lipoproteins such as low density lipoproteins (LDL) and their partially catabolized precursors, very low density lipoprotein (VLDL) remnants, from the blood (1,2). Yet, the removal mechanisms for chylomicron remnants and high density lipoproteins (HDL) have still to be solved.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Brown, M.S. and J.L. Goldstein. (1986). A receptor-mediated pathway for cholesterol homeostasis. Science. 232: 34–47.
Havel, R.J. and R.L. Hamilton. (1988). Hepatocytic lipoprotein receptors and intracellular lipoprotein catabolism. Hepatology. 8: 1689–1704.
Scott, J. (1990). Regulation of the biosynthesis of apolipoprotein B100 and apolipoprotein B48. Curr. Opinion Lipidol. 1: 96–103.
Greeve, J., N. Navaratnam and J. Scott. (1991). Characterization of the apolipoprotein B mRNA editing enzyme: no similarity to the proposed mechanism of RNA editing in kinetoplastid protozoa. Nucl.Acid Res. 19: 3569–3576.
Windier, E. and R. J. Havel. (1985). Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liverJ. Lipid Res. 26: 556–565.
Windler, E.E.T., S. Preyer and H. Greten. (1986). Influence of lysophosphatidylcholine on the C-apoprotein content of rat and human triglycéride rich lipoproteins during triglyceride hydrolysis. J.Clin.lnvest. 78: 658–665.
Jäckie, S., S.E. Brady and RJ. Havel. (1989). Membrane binding sites for plasma lipoproteins on endosomes from rat liver. Proc.Natl.Acad.Sci.USA. 86:1880–1884.
Jäckie, S., E. Runquist, S. Brady, R. L. Hamilton and R. J. Havel. (1991). Isolation and characterization of three endosomal fractions from the liver of normal rats after lipoprotein loading. J. Lipid Res. 32: 485–498.
Windler, E.E.T., J. Greeve, W. H. Daerr and H. Greten. (1988). Binding of rat chylomicrons and their remnants to the hepatic low-density-lipoprotein receptor and its role in remnant removal. Biochem J. 252: 553–561.
Windier, E., J. Greeve, B. Levkau, V. Kolb-Bachofen, W. Daerr and H. Greten. (1991). The human asialoglycoprotein-receptor is a possible binding site for low density lipoproteins and chylomicron remnants. Bio chem J. 276:79–87.
Jäckie, S., F. Rinninger, J. Greeve, H. Greten and E. Windier. (1992). Regulation of the hepatic removal of chylomicron remnants and ß-very low density lipoproteins in the rat. J. Lipid Res. 33: 419–429.
Erickson, S.K., S. Jäckie, S.R. Lear, S.M. Brady and RJ. Havel. (1989). Regulation of hepatic cholesterol and lipoprotein metabolism in ethinyl estradiol treated rats. J.Lipid Res. 30: 1763–1771.
Brown, M.S., J. Herz, R.C. Kowal and J.L. Goldstein. (1991). The low-density lipoprotein receptor-related protein: double agents or decoy? Curr. Opinion Lipidol. 2: 65–72.
Beisiegel, U., W. Weber, G. Ihrke, J. Herz and K. K. Stanley. (1989). The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein. Nature. 341: 162–164.
Beisiegel, U., W. Weber and G. Bengtsson-Olivecrona. (1991). Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor related protein. Proc. Natl. Acad. Sci. USA. 88: 8342–8342.
Reichl, D. and N. E. Miller. (1989). Pathophysiology of reverse cholesterol transport; insights from inherited disorders of lipoprotein metabolism. Arteriosclerosis. 9: 785–797.
Rinninger, F. and R.C. Pittman. (1987). Regulation of the selective uptake of high density lipoprotein-associated cholesteryl esters J. Lipid Res. 28:1313–1325.
Rinninger, F. and R.C. Pittman. (1988). Regulation of the selective uptake of high density lipoprotein-associated cholesteryl esters by human fibroblasts and Hep G2 hepatoma cells. J. Lipid Res. 29: 1179–1194.
Rinninger, F. and R.C. Pittman. (1989). Mechanism of the cholesteryl ester transfer protein-mediated uptake of high density lipoprotein cholesteryl esters by Hep G2 Cells. J. Biol. Chem. 264: 6111–6118.
Rinninger, F. and H. Greten. (1990). High density lipoprotein particle uptake and selective uptake of high density lipoprotein-associated cholesteryl esters by J774 macrophages. Biochim. Biophys. Acta. 1043: 318–326.
Belcher, J.D., R.L. Hamilton, S.E. Brady, C.A. Hornick, S. Jäckie, W.J. Schneider and R.J. Havel. (1987). Isolation and characterization of three endosomal fractions from the liver of estradiol-treated rats. Proc. Natl. Acad. Sci. USA. 84: 6785–6789.
Jäckie, S., E.A. Runquist, S. Miranda-Brady and R.J. Havel (1991). Trafficking of the epidermal growth factor receptor and transferrin in three hepatocytic endosomal fractions. J. Biol. Chem. 266: 1396–1402.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Jäckle, S., Rinninger, F., Greeve, J., Beisiegel, U., Windler, E., Greten, H. (1993). Receptor Mediated Hepatic Uptake of Lipoproteins. In: Schettler, G., Greten, H., Habenicht, A.J.R. (eds) Cellular Metabolism of the Arterial Wall and Central Nervous System. Sitzungsberichte der Heidelberger Akademie der Wissenschaften, vol 1993/94 / 1993/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84949-7_12
Download citation
DOI: https://doi.org/10.1007/978-3-642-84949-7_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-56603-8
Online ISBN: 978-3-642-84949-7
eBook Packages: Springer Book Archive