Structure of the mammalian centromere
The quest to understand the structure and function of the centromere dates back almost a century, when this specialized region of the chromosome was first described in 1894 by Metzner as the site at which chromosomes attached to the spindle apparatus (Metzner, 1894). Even before the genetic consequences of chromosome movement had been demonstrated, it was realized that the centromere was intimately involved in the distribution of nuclear material during cell division.
KeywordsPhosphorus Recombination Fractionation Proline Polypeptide
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- Dvorkin, N. and Hamkalo, B. A. (1991). The distribution of alpha satellite sequences in African green monkey chromosomes. J. Cell Biol. 115, 92a.Google Scholar
- Lorbeer, G. (1934). Die zytologie der lebermoose mit beonderer berucksichtigung allgemeiner Chromosomenfragen. Jahrb. wiss. Bot. 80, 576.Google Scholar
- Metzner. (1894). Beitrge zur granulalehre. Arch, Anat. u. Physiol. 309–325.Google Scholar
- Ohtsubo, M., Kai, R., Furuno, N., Sekiguchi, T., Sekiguchi, M., Hayashida, H., Kuma, K., Miyata, T., Fukushige, S., Murotu, T., Matsubara, K. and Nishimoto, T. (1987). Isolation and characterization ofthe active cDNA of the human cell cycle gene (RCC1) involved in the regulation of onset of chromosome condensation. Genes Develop. 1, 585–593.PubMedCrossRefGoogle Scholar
- Rieder, C. L. and Alexander, S. P. (1989). The attachment of chromosomes to the mitotic spindle and the production of aneuploidy in newt lung cells. In Mechanisms of Chromosome Distribution and Aneuploidy (ed. M. A. Resnick and B. K. Vig), 185–194. New York: Alan R. Liss.Google Scholar
- Zinkowski, R. P., Meyne, J. and Brinkley, B. R. (1991). The centromere-kinetochore complex: a repeat subunit model. J. Cell Biol. 113,Google Scholar