Structure of the mammalian centromere

  • John E. Tomkiel
  • William C. Earnshaw
Part of the NATO ASI Series book series (volume 72)


The quest to understand the structure and function of the centromere dates back almost a century, when this specialized region of the chromosome was first described in 1894 by Metzner as the site at which chromosomes attached to the spindle apparatus (Metzner, 1894). Even before the genetic consequences of chromosome movement had been demonstrated, it was realized that the centromere was intimately involved in the distribution of nuclear material during cell division.


Centromere Protein Alpha Satellite Chromosome Movement Centromeric Chromatin Indian Muntjac 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • John E. Tomkiel
    • 1
  • William C. Earnshaw
    • 1
  1. 1.Department of Cell Biology and AnatomyJohns Hopkins University School of MedicineBaltimoreUSA

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