Gammopathy pp 79-94 | Cite as

Polyclonal gammopathies

  • János Jákó


Gammopathies are defined as pathological changes of the quantity, disproportions between different fractions, and the alteration of the physico-chemical and functional properties of immunoglobulins. Pathomorphological changes are always involved in this pathology even if it is difficult to detect them. Waldenstrôm was the first to introduce the term gammopathia (137).


Primary Biliary Cirrhosis Helper Cell Suppressor Cell Blast Transformation Lymphoid System 
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  1. 1.
    Adorini, L. Basic strategies of the immune system in the regulation of antibody response. La Ricerca. 10,2. 1980.Google Scholar
  2. 2.
    Adorini, L., Eipert, E. F., Couderc, J. Immunoadsorbent removal of antibodies produced during in vitro culture relieves inhibition of the response. Cell. Immunol. 47,356.1979.PubMedGoogle Scholar
  3. 3.
    Akdamar, K., Epps, A. C, Maumus, L. T., Sparks, R. D. Immunoglobulin changes in liver disease. Ann. N. Y. Acad. Sci. 197,101. 1972.PubMedGoogle Scholar
  4. 4.
    Andersson, J., Sjöberg, O., Möller, G. Induction of immunoglobulin and antibody synthesis in vitro by lipopolysaccharide. Eur. J. Immunol. 2, 349. 1972.PubMedGoogle Scholar
  5. 5.
    Andersson, J., Sjöberg, O., Möller, G. Mitogens as probes for immunocyte activation and cellular cooperation. Transplant. Rev. 11,131. 1972.PubMedGoogle Scholar
  6. 6.
    Argyris, B. F. Role of suppressor cells in immunological maturation. Transplantation. 31,334. 1981.PubMedGoogle Scholar
  7. 7.
    Arrigoni — Martelli, E. Developments in drugs enhancing the immune responser. Meth. and Find. Exptl. Clin. Pharmacol. 3, 247. 1981.Google Scholar
  8. 8.
    Bach,G. Ein Fall von subakuter Hepatitis mit Übergang in Cirrhose, Gamma-G-Paraproteinaemia und positiver Rheumaserologie. Wien. med. Wschr. 120,726. 1970.PubMedGoogle Scholar
  9. 9.
    Bauer, H., Paronetto, F., Porro, R. F., Einheber, A. Gamma-globulin elevation in chronic liver injury of germ-free and conventionalised rats. Fed. Proc. 25,667. 1966.Google Scholar
  10. 10.
    Bellanti,J. A. Immunology. JAMA 247,2957. 1982.Google Scholar
  11. 11.
    Bergman, S., Weibull, C. Effects of endotoxin on tissue culture cells. Acta Path. Microbiol. Scand. 77, 698. 1969.PubMedGoogle Scholar
  12. 12.
    Bjorneboe, M., Jensen, K. B., Scheibel, I., Thomsen, A. Chr, Bentzo,M. W. Tetanus antitoxin production and gamma-globulin levels in patients with cirrhosis of the liver. Acta. Med. Scand. 188, 541. 1970.PubMedGoogle Scholar
  13. 13.
    Bjorneboe, M., Proytz, H., Örekov, F. Antibodies to intestinal microbes in serum of patients with cirrhosis of the liver. Lancet. i. 58. 1972.Google Scholar
  14. 14.
    Boulet, P., Mirouze, P., Barjon, M., Robinet, M. L’immunoélectrophorèse sérique des cirrhoses hépatiques. Sem. Ho. Paris. 37, 415. 1961.Google Scholar
  15. 15.
    Bucher, N. L. R., Schott, J. F., Aub, J. C. Regeneration of the liver in parabiotic rats. Cancer Res. 10, 207. 1950.Google Scholar
  16. 16.
    Bufano,M. Über die Pathogenese der Dysproteinämien. Münch. med. Wschr. 32,1448. 1970.Google Scholar
  17. 17.
    Ceuppens, J., Goodwin, J. S. Prostaglandins and the Immune Response to Cancer. Anticancer Research. 1,71. 1981.PubMedGoogle Scholar
  18. 18.
    Ceuppens, J. L., Goodwin, J. S. Endogenous prostaglandin E2 enhances polyclonal immunoglobulin production by tonically inhibiting T suppressor cell activity. Cellular immunology. 70, 41. 1982.PubMedGoogle Scholar
  19. 19.
    Chiorazzi, N., Fu, S. M., Kundel, H. G. Induction of polyclonal antibody synthesis by human allogeneic and autologous helper factors. J. Exp. med. 149,1543. 1979.PubMedGoogle Scholar
  20. 20.
    Coburg, A. J., Seifert, E., Deicker, H. Zur Differenzierung immunoglobulinhaltiger Zellen in der Leber bei entzündlichen Lebererkrankungen. Acta hepato-splenol. 18,1.1971.Google Scholar
  21. 21.
    Cohen, S., Ohta, G., Singer, E. J., Rosenfield, R. E., Permann, E., Popper, H. The demonstration of gamma-globulin in livers with postnecrotic cirrhosis and fulminating viral hepatitis, using the flourescent antibody technique. Amer. J. Path. 35,685.1959.Google Scholar
  22. 22.
    Cohen, S., Ohta, G., Singer, E. J., Popper, H. Immunochemical study of gamma-globulin in liver in hepatitis and postnecrotic cirrhosis. J.exp. Med. 111,285. 1960.PubMedGoogle Scholar
  23. 23.
    Coons, A. H., Kaplan, M. H. Localisation of antigen in tissue cells. J.exp. med. 91,1. 1950.PubMedGoogle Scholar
  24. 24.
    Coutinho, A., Möller, G. Immune activation of B cells evidence for „one nonspecific triggering signal” not delivered by the Ig receptors. Scand. J. Immunol. 3,133. 1974.PubMedGoogle Scholar
  25. 25.
    Davies, A. J., Carter, R. L., Leuchars, E., Wallis, V., Dietrich, F. M. The morphology of immune reactions in normal thymectomised and reconstitued mice. III. Response to bacterial antigens: salmonellar flagellar and pneumococcal polysaccharide. Immunology. 19,945. 1970.PubMedGoogle Scholar
  26. 26.
    Dutton, R. W., Eady, J. D. An in vitro system for the study of the mechanism of antigenic stimulation in the secondary response. Immunology. 7,40. 1964.PubMedGoogle Scholar
  27. 27.
    Eisbach, M., Roubinian, J. R., Talal, N. Lipopolysaccharide induction of IgM antibodies to polyadenylic acid in normal mice. J. Immunol. 120,1856. 1978.Google Scholar
  28. 28.
    Falkoff, R. M., Scavulli, J. F., Dutton, R. W. Independent analysis of T helper and T killer cell function in young and old NZB mice. J. Immunol. 121, 897. 1978.PubMedGoogle Scholar
  29. 29.
    Farrar, W. R., Corwin, L. M. The essential role of the liver in detoxification of endotoxin. Ann. N. Y. Acad. Sci. 133, 668. 1966.PubMedGoogle Scholar
  30. 30.
    Farrar, W.E. In „La structure et les effects biologiques des products bacteriens provevant de germes Gramnegativs”. Cent. Mat. Rech. Sci. 455. Paris 1969.Google Scholar
  31. 31.
    Fauci, A. S., Steinberg, A. D., Haynes, B. F., Whalen, G. Immunoregulatory abberations in systemic lupus erythematosus. J.Immunol. 121,1473. 1978.PubMedGoogle Scholar
  32. 32.
    Feizi,T. Immunoglobulins in chronic liver disease. Gut. 9,193. 1968.PubMedGoogle Scholar
  33. 33.
    Ferraris, V. A., DeRubertis, F. R. Release of prostaglandin by mitogen — and antigen — stimulated leukocytes in culture. J.Clin. Invest. 54, 378. 1974.PubMedGoogle Scholar
  34. 34.
    Fidalgo,B. V.,Najjar, V. A.,Zukoski,C. F., Katayama, Y. The physiological role of the lymphoid system. II. Erythrophilic gamma-globulin and the survival of the erythrocyte. Nat. Acad. Sci. 57, 665. 1967.Google Scholar
  35. 35.
    Fidalgo, B. V., Najjar, V. A. The physiological role of the lymphoid system. III. Leucophilic globulin and the phagocytic activity of the polymorphonuclear leucocyte. Proc. Nat. Acad. Sci. 57, 957. 1967/a.PubMedGoogle Scholar
  36. 36.
    Fidalgo, B.V., Najjar, V. A. The physiological role of the lymphoid system. IV. The stimulatory effect of leucophilic globulin (leucokinen) an the phagocytic activity of human polymorphonuclear leucocyte. Biochemistry. 6,3386. 1967/b.PubMedGoogle Scholar
  37. 37.
    Fidalgo, B. V., Katayama, Y., Najjar, V. A. The physiological role of the lymphoid system. V. The binding of autologous (erythrophilic) gamma-globulin to human red blood cells. Biochemistry. 6, 3378. 1967/c.PubMedGoogle Scholar
  38. 38.
    Fink, C. W., Miller, W. E., Dorward, B., Lospalutto, J. The formation of macroglobulin antibodies. II. Studies on neonatal infants and older children. J. Clin. Invest. 41,1422. 1962.PubMedGoogle Scholar
  39. 39.
    Fischer, A., Kerekes E., Bona, A. Májregenerációt serkentő humoralis tényező kimutatása. Orvosi Hetilap. 102,66. 1961.PubMedGoogle Scholar
  40. 40.
    Roch, M. H., Katz, J., Conn, H. O. Qualitative and quantitative relationsips of the fecal flora in cirrhotic patients wirt portal systemic encephalopathy and following portacaval anastomosis. Gastroenterol. 59,70. 1970.Google Scholar
  41. 41.
    Fournié, G. J., Lambert, P. H., Miescher, P. A. Release of DNA in circulating blood and induction of anti-DNA antibodies after injection of bacterial lipopolysacchari-des. J.exp.Med. 140,1189.1974.PubMedGoogle Scholar
  42. 42.
    Fudenberg, H. H. Are autoimmune diseases immunologic deficiency states? Hosp. Pract. 3,43.1968.Google Scholar
  43. 43.
    Fudenberg, H. H. Genetically determined immune deficiency as the predisposing cause of „autoimmunity” and lymphoid neoplasia. Amer. J. Med. 51,295. 1971.PubMedGoogle Scholar
  44. 44.
    Fudenberg, H. H. Are autoimmune diseases and malignancy due to selective T-cell deficiencies? Critical factors. Cancer. Immunol. 10,179. 1975.Google Scholar
  45. 45.
    Fudenberg, H. H., Wells, J. V. The paradox of immunosuppression: T-cell deficiency as the cause of autoimmunity. In: Infection and immunology in rheuma diseases. Ed.: by Dumonde, D. C. Blackwell Scientific Publications, Oxford 549. 1976.Google Scholar
  46. 46.
    Fudenberg, H. H. Molecular theology, immunophilosophy, and autoimmune disease. Scand. J. Immunol. 12,459. 1980.PubMedGoogle Scholar
  47. 47.
    Furchgott, R. E., Ponder, E. Disc-sphere transformation in mammalian red cells. II. The nature of the antisphering factor. J. Exptl. Biol. 17,117. 1940.Google Scholar
  48. 48.
    Gerry, I., Krüger, J., Spiesel, S.Z. Stimulation of B-lymphocytes by endotoxin. Reactions of thymus-deprived mice and karyotipic analysis of dividing cells in mice bearing T6thymus grafts. J. Immunol. 108,1088.1972.Google Scholar
  49. 49.
    Gifford, R. R. M., Ferguson, R. N., Voss, B. V. Cimetidine reduction of tumor formation in mice. Lancet, i,38.1981.Google Scholar
  50. 50.
    Gleichmann, E., Deicher, H. Differenzierung der Hypergammaglobulinämie bei entzündlichen Lebererkrankungen. Klin. Wschr. 45,684.1967.PubMedGoogle Scholar
  51. 51.
    Gleichmann, E., Deicher, H. Quantitative Immunoglobulin-Bestimmungen im Serum bei entzündlichen Lebererkrankungen. I. Normalwerte und Untersuchungen im Verlauf der akuten Hepatitis. Klin. Wschr. 46,171. 1968.PubMedGoogle Scholar
  52. 52.
    Gleichmann, E., Deicher, H. Quantitative immunoglobulin-Bestimmungen im Serum bei entzündlichen Leberkrankheiten. II. Chronisch entzündlichen Leberkrankheiten. Klin. Wschr. 46,793.1968.Google Scholar
  53. 53.
    Goodman, M.G Weigle, W.O. Induction of immunoglobulin secretion by a simple nucleoside derivative.J. of Immunol. 128,2399. 1982.Google Scholar
  54. 54.
    Goodwin, J. S., Messner, R. P., Bankhurst, A. D., Peake, G. T., Saiki, J., Williams, R. C. Jr. Prostaglandinproducing suppressor cells in Hodgkin’s Disease. N. Engl. J. Med. 297,963. 1977.PubMedGoogle Scholar
  55. 55.
    Goodwin, J. S., DcHoratius, R., Israel, H., Peake, G. T., Messner, R. P. Suppressor cell function is sarcoidosis. Ann. Intern. Med. 90,169. 1979.PubMedGoogle Scholar
  56. 56.
    Guardia, J., Pedreira, J. D., Vidal, M. T., Roca, A. Malignant lymphoma with plasmocytoid differentation and polyclonal gammopathy. Acta Haematol 55,346. 1976.PubMedGoogle Scholar
  57. 57.
    Gustaffson, B. E., Laurell, C. B. Gamma-globulin production in germfree rats after bacterial contamination. J. Exp. Med. 110,675. 1959.Google Scholar
  58. 58.
    Hammarström, L., Smith, E., Primi, D., Möller, G. Induction of autoantibodies to red blood cells by polyclonal B-cell activators. Nature. 263,60. 1976.PubMedGoogle Scholar
  59. 59.
    Hammarström, L., Bird, A. G., Smith, C. I. E. Mitogenic activation of human lymphocytes: a protein A plaque assay evaluation of polyclonal B-cell activators. Scand. J. Immunol. 11,1. 1980.PubMedGoogle Scholar
  60. 60.
    Hartmann, G., Burtin, P., Grabar, P., Fauvert, P. L’analyse immuno-electrophoretique des serum de malades atteints d’affections hepatiques. C. R. Acad. Sci. (Paris) 243,1937. 1956.Google Scholar
  61. 61.
    Hashim,G. A. Myelin basic protein: structure, function and antigenic determinants. Immunol. Rev. 39, 60. 1978.PubMedGoogle Scholar
  62. 62.
    Heremans, J. F. Quelques données de l’immunoélectrophorèse en pathologie hépatique. Acta. Gastroent. Belg. 22, 582,1959.PubMedGoogle Scholar
  63. 63.
    Hitzig,W.H. Clinical effects of anomalous serum globulins. Clin. Prot. Chem. Basel. 1,72. 1968.Google Scholar
  64. 64.
    Hobbs,J.R. Serum proteins in liver disease. Proc. Roy. Soc. Med. 60,1250. 1967.PubMedGoogle Scholar
  65. 65.
    Hollán,Zs.,Solti,V. A serum fehérjekép dynamikus változásával és lipaemiával jaró „Szőlőfürt-sejtes” plasmocytoma. Haemat. Hung. 3,157.1963.Google Scholar
  66. 66.
    Horváth. É., Biliczky, F., Jákó, J., Hámori, É. Some problems of humoral regulation of liver regeneration. Acta Biol. Acad. Sci. Hung. 5,47. 1963.Google Scholar
  67. 67.
    Jákó, J., Szirtes, M., Szigeti, I. Latex vizsgálatok különböző betegségekben, s ezek positivi-tásának összefüggése az immunoglobulinokkal. Rheum. Baln. Allerg. 2, 99. 1966.Google Scholar
  68. 68.
    Jákó,J.,Tóth,B.,Szigeti,I. A titratios immunelectrophoresis klinikai alkalmazása. Magyar Belorv. Arch. 20,120. 1967.Google Scholar
  69. 69.
    Jákó, J., Sas, G. Vérfehérje változások chronicus májbetegségekben: a „közvetlen” és „közvetett” májfunctios próbák. Orv. Hetil. 109,1526. 1968.PubMedGoogle Scholar
  70. 70.
    Jákó, J., Sas, G. The effect of endotoxin on blood proteins. Ann. Immunol. Hung. 12, 79. 1968.Google Scholar
  71. 71.
    Jákó,J. Fehérjeanyagcsere vizsgálatok májbetegségekben. Kandidátusi dissertatio 1973.Google Scholar
  72. 72.
    Jarrold, T., Vilter, R.W. Hematologic observation in patients with chronic hepatic insufficiency. Sternal marrow morphology and bone marrow plasmacytosis. J.Clin. Invest. 28, 286. 1949.Google Scholar
  73. 73.
    Jerne,N. K. Towards a network theory of the immune system. Ann. Immunol. (Inst. Pasteur) 1250,373. 1974.Google Scholar
  74. 74.
    Katz,P.Fauci.A. S. Inhibition of polyclonal B-cell activation by suppressor monocytes in patients with sarcoidosis. Clin. Exp. Immunol. 32, 554. 1978.PubMedGoogle Scholar
  75. 75.
    Kelly, RH, Hardy, T. J. Multiple clonally-restricted immunoglobulins in human sera: disease associations. Inl. Arch. Allergy Appl. Immun. 69, 56. 1982.Google Scholar
  76. 76.
    Kennan, A. L. Changes in plasma proteins after portocaval shunt in the rat. Proc. Soc. exp. Biol. 116,453. 1964.Google Scholar
  77. 77.
    Kim, Y. B., Bradley, S. G., Watson, D. W. IV. the role of antigen elimination in the true primary immune response in germfree, colostrum-deprimed piglets. J. Immunol. 99, 320. 1967.PubMedGoogle Scholar
  78. 78.
    Lahiri, A. K. Dissertation in partial fulfilment of the requirement for the degree of Doctor of Phyilosophy, June, 1968. Vanderbilt University, Mash ville, Tenn. Cit: Najjar, V. A.: The physiolocical role of the lymphoid system. Leb. Med. J. 22,401. 1969.Google Scholar
  79. 79.
    Manning, D. D. In vivo immune stimulation of mice by anti-μ antibodies: generation of high serum levels of a low molecular weight IgM product. Cell. Immunol. 50,348. 1980.PubMedGoogle Scholar
  80. 80.
    McCombs, C, Horn, J., Talai, N., Michel, R. Functional deficiency of splenic adherent cells in NZ black mice. J. Immunol. Rev. 115,1695. 1975.Google Scholar
  81. 81.
    McHougl,Y. E.,Bonavida,B. Autoreactiv antibody-forming cells directed against thymocytes and thymus-derived lymphocytes. J.Immunol. 121,1090. 1978.Google Scholar
  82. 82.
    Melchers, F., Andersson, J., Lemhardt, W., Schreier, M. H. Role of surface-bound immunoglobulin molecular in regulating the replication an maturation to immunoglobulin secretion of B lymphocytes. Immunol. Rev. 52,89. 1980.PubMedGoogle Scholar
  83. 83.
    Metcalf,D. Role of mercaptoethanol and endotoxin in stimulating Blymphocyte colony formation in vitro. J. Immunol. 166,635. 1976.Google Scholar
  84. 84.
    Miller, J. A. F. P. Immunity in the foetus and the newborn. Brit. med. Bulletin. 22, 21. 1966.Google Scholar
  85. 85.
    Miller, K. B., Salem, D. Immune regulatory abnormalities produced by procainamid. Amer. J. Med. 73,487. 1982.PubMedGoogle Scholar
  86. 86.
    Miller, L. L., Bly, C. G., Bale, W. F. Plasma and tissue proteins produced by non hepatic rat organs as studied with lysine E-C14. Gamma-globulins the chief plasma protein fraction produced by non-hepatic tissues. J. Exp. Med. 99,133. 1954.PubMedGoogle Scholar
  87. 87.
    Moghadam, F., Lamers, A., Reisenburg, J., Kendel, M. I. Significance of immunoglobulins to the diagnosis of liver and assesment of evolution of liver diseases. Klin. Wschr. 47,129. 1969.Google Scholar
  88. 88.
    Morito, T., Bankhurst, A. D., Williams, R. C. Studies on the pharmacologic manipulation of suppressor cells associated with impaired immunoglobulin production. J. Lab. Clin. Med. 96, 232. 1980.PubMedGoogle Scholar
  89. 89.
    Möller, G. Autoimmunity and self-nonself discrimination. Transplant. Rev. 31,1. 1976.Google Scholar
  90. 90.
    Möller, G. Activation of antibody synthesis in human B lymphocytes. Immunol. Rev. 45,1. 1979.Google Scholar
  91. 91.
    Muckerheide, A., Pesce, A. J., Michael, G. J. Immunosuppressive properties of a peptic fragment of BSA. J. Immunol. 199,1340. 1977.Google Scholar
  92. 92.
    Najjar, V. A. The physiological role of the lymphoid system. Lab. Med. J. 22,4. 1969.Google Scholar
  93. 93.
    Nowotny, A. Recent problems of endotoxin research. An. Immunol. Hung. 12,15. 1968.Google Scholar
  94. 94.
    Oppenheim, J. J, Perry, S. Effects of endotoxins on cultured leukocytes. Proc. Sec. exp. Biol. Med. 118,1014. 1965.Google Scholar
  95. 95.
    Osband, M. E., Jinshen, Y., Shlesinger, M., Brown, A., Hamilton, D., Cohen, E., Lavin, P. McAffrey, R. Successful tumor immunotherapy with Cimetidine in mice. Lancet, i. 636. 1981.Google Scholar
  96. 96.
    Ossermann, E. F., Takatsuki, K. The plasma proteins in liver disease. Med. clin. N. Amer. 47, 679. 1963.Google Scholar
  97. 97.
    Palmer, D. W., Dauphinee, M. J., Hurphy, E., Talal, N. Hyperactive T cell function in young NZB mice: Increased proliferative responses to allogenetic cells. Clin. Exp. Immunol. 23, 578. 1976.PubMedGoogle Scholar
  98. 98.
    Paronetto, E., Rubin, E., Popper, H. Local formation of γ—globulin in the diseased liver and its relation to hepatic necrosis. Lab. Invest. 11,150. 1962.PubMedGoogle Scholar
  99. 99.
    Paronetto, E., Schaffner, F., Popper, H. Immunocytochemical and serologic observations in primary biliary cirrhosis. New Eng. J. Med. 271, 1123. 1964.PubMedGoogle Scholar
  100. 100.
    Peavy, D. L., Adler, W. H., Smith, R. T. The mitogenic effects of endotoxin and staphylococcal enterotoxin B on mouse spleen cells and human peripherial lymphocytes. J. Immunol. 105,1453. 1970.PubMedGoogle Scholar
  101. 101.
    Peterman, M. L. Alterations in plasma proteins patterns in disease. In: The plasma proteins. Ed.: Putnam, R. W. Academic press New York. 2, 310. 1960.Google Scholar
  102. 102.
    Pierce C. W. Immune responses in vitro. II. Suppression of the immune response in vitro by specific antibody. J. exp. Med. 143, 672. 1976.Google Scholar
  103. 103.
    Plaut, E. M., Goldman, J. K. Inhibition of substrate oxidation by endotoxin in vitro. Proc. Soc. exp. Biol. Med. 133,433. 1970.PubMedGoogle Scholar
  104. 104.
    Primi, D., Hammarström, L., Smith, C. I. E., Möller, G. Characterization of selfreactive B cells by polyclonal B-cell activators. J.exp. Med. 145,21. 1977.PubMedGoogle Scholar
  105. 105.
    Raeder, R., Preimer, E. H., Pansky, B., Senitzer, D. Response of peripheral blood lymphocytes from the (NZ B) (NZ W) F1 mouse to phytohemagglutinin. Clin. Immunol. Immunopathol. 6, 174. 1976.PubMedGoogle Scholar
  106. 106.
    Rebeyrotte, P., Baujat, J. P., Labbe, J. P., Koutsoukos, A. Application de 1a technique d’immunoelectrophorese bi-di-;mensionelle au probleme des cirrhoses. Pathol, biol. 18,653. 1970.Google Scholar
  107. 107.
    Reinherz, E. L, Schlossman, S. F. The differentiation and function of human T lymphocytes. Cell. 19,821. 1980.PubMedGoogle Scholar
  108. 108.
    Reinherz, E. L., Schlossman, S. F. The characterization and function of human immunoregulatory T lymphocyte subsets. Immunol. Today. 2, 69. 1981.Google Scholar
  109. 109.
    Rosen, A., Gergely, P., Jondal, M., Klein, G., Britton, S. Polyclonal Ig production after Epstei-Barr virus infection of human lymphocytes in vitro. Nature. 267, 52. 1977.PubMedGoogle Scholar
  110. 110.
    Rosenthal, A. S., Barcinski, M. A., Blake, J. T. Determinant selection is a macrophage dependent immune response gene function. Nature. 267, 156. 1977.PubMedGoogle Scholar
  111. 111.
    Rowley, D. A., Fitch, F. W., Axelrad, M. A, Pierce, C. W. The immune response suppressed by specific antibody. Immunology. 16,549. 1969.PubMedGoogle Scholar
  112. 112.
    Sagawa, A., Abdov, N. I. Suppressor cell dysfunction in systemic lupus erythematosus. Cells involved and in vitro correlation. J. Clin. Invest. 62,789. 1978.PubMedGoogle Scholar
  113. 113.
    Schenkein, I., Uhr, J.W. Immunoglobulin synthesis and secretion. I. Biosynthetic studies of the addition of the carbohydrate moieties. J. Cell. Biol. 46, 42. 1970.PubMedGoogle Scholar
  114. 114.
    Schneiberg, K., Jonecko, A., Bartnikova, W., Szymaniec, S. Lymphocyte as a myeloid cell precursor. Japan, J. Exp. Med. 39, 331. 1969.Google Scholar
  115. 115.
    Schneiderbaur, A., Narbeshuber, H. The significance of plasmocytosis in the sternal marrow in liver cirrhoses. Wien. med. Wschr. 113, 370. 1963.PubMedGoogle Scholar
  116. 116.
    Sell, S., Fahey, J. Relationship between gamma-globulin metabolism low serum gamma-globulin in germfree mice. J. Immun. 93, 81. 1964.PubMedGoogle Scholar
  117. 117.
    Sercarz, E. E., Yowell, R. L., Turkin, D., Miller, A., Araneo, B. A., Adorini, L. Different funtcional specificity repertoires for suppressor and helper T cells. Immunol. Rev. 39,108. 1978.PubMedGoogle Scholar
  118. 118.
    Shearer, G. M., Rehn, T. G., Garbarino, C. A. Cell mediated lympholysis of trinitrophenylmodified autologous lymphocytes. Effector cell specificity to modified cell surface components controlled by the H-2D and H-2K serological regions of the major histocompatibility gene products. J.exp. Med. 141,1348. 1975.PubMedGoogle Scholar
  119. 119.
    Scherlock, S. The immunology of liver disease. Amer. J. Med. 49, 693. 1970.Google Scholar
  120. 120.
    Sinclair, N. R. Immunoregulation by antibody and antigen-antibody complexes. Transplant. Proc. 10, 349. 1978.Google Scholar
  121. 121.
    Sjöberg, O. Antigen-binding cells in mice immune or tolerant to Escherichia Coli polysaccharide. J.exp. Med. 133,1015. 1971.PubMedGoogle Scholar
  122. 122.
    Stich, M. H., Swiller, A. I., Morrison, M. The grape cells of multiple myeloma. Amer. J. Clin. Path. 25, 601. 1955.Google Scholar
  123. 123.
    Sultzer, B. M., Nilsson, B. S. PPD tuberculin — a B cell mitogen. Nature New Biol. 240, 198. 1972.PubMedGoogle Scholar
  124. 124.
    Talal,N. Autoimmunity: genetic, immunologic, virologic and clinical aspects. New York. Academic Press. Inc. 1977.Google Scholar
  125. 125.
    Teodorescu, M. Characterization and role in autoimmune diseases of the polyclonal B-cell activator produced by T-cells — The helper factor. Immunological Rev. 55,155. 1981.Google Scholar
  126. 126.
    Thorbecke,G.J. Some histological and functional aspects of lymphoid tissue in germfree animals. I. Morpological studies. Ann. N. Y. Acad. Sci. 78, 237. 1959/a.PubMedGoogle Scholar
  127. 127.
    Thorbecke G.J. Some histological and functional aspects of lymphoid tissue in germfree animals. II. Studies on phagocytosis in vivo. Ann. N. Y. Acad. Sci. 78, 247. 1959/b.PubMedGoogle Scholar
  128. 128.
    Tholey-Lawson, D. A. The suppression of Epstein-Barr virus infection in vitro occurs after infection but before transformation of the cell. J.Immunol. 124,745. 1980.Google Scholar
  129. 129.
    Tiselius, A.,Kabat,E. A. An electrophoretic study of immune sera and purified antibody preparations. J.exp. Med. 69,119. 1939.PubMedGoogle Scholar
  130. 130.
    Tomasi, T. B., Tisdale, W. A. Serum gamma-globulins in acute chronic liver disease. Nature. 201,834. 1964.PubMedGoogle Scholar
  131. 131.
    Tompkins, E.H. The effects of washing and of serum albumin upon erythrocyte. I. Upon morphology as seen with phase microscopy and with polarized light. J. Lab. Clin. Med. 43, 518. 1954/a.PubMedGoogle Scholar
  132. 132.
    Tompkins. E. H. The effects of washing and of serum albumin upon erythrocytes. II. Upon the internal movement of erythrocytes. J. Lab. Clin. Med. 43, 527. 1954/b.PubMedGoogle Scholar
  133. 133.
    Trejo, R. A., Di Luzio, N. R. Influence of reticuloendothelial system (RES) functional modification on endotoxin detoxication by liver and spleen. J. Reticuloendth. Soc. 10, 515. 1971.Google Scholar
  134. 134.
    Triger, D. R., Alp, M. H., Wright, R. Bacterial and dietary antibodies in liver disease. Lancet. i. 60. 1972.Google Scholar
  135. 135.
    Turkin, D., Sercarz, E. E. Key antigenic determinants in regulation of the immune response. Proc. nat. Acad. Sci. 74, 3984. 1977.PubMedGoogle Scholar
  136. 136.
    Uhr, J. W., Dancis, J., Franklin, E. C, Finkelstein, M. S., Lewis, E. W. The antibody response to bacteriophage ∅X 174 in newborn premature infants. J. Clin. Invest. 41,1509. 1962.PubMedGoogle Scholar
  137. 137.
    Waldenström, J. Studies on conditions associated with disturbed gamma-globulin formation (gammapathies). Harvey Lect. 56,211. 1960.PubMedGoogle Scholar
  138. 138.
    Waldenström, J. The different types of disturbed gamma-globulin formation. In: Structure and control biosynthesis. Nobel Symposium 3. Ed.: by Kilander, J. Interscience Publications. New York. 527,1967.Google Scholar
  139. 139.
    Waldmann, T. A., Broder, S. Suppressor cells in the regulation of the immune response. Prog. Clin. Immunol. 3,155. 1977.PubMedGoogle Scholar
  140. 140.
    Walls, R. S.,Beeson,P. B. Mechanism of eosinophilia. IX. Induction of eosinophilia in rats by certain forms of dextran. Exp. Biol. Med. 140, 689. 1970.Google Scholar
  141. 141.
    Wuhrman, F,Wunder,Ch. The human blood proteins. Grune-Stratton New York and London. 1960.Google Scholar
  142. 142.
    Zagury, D., Uhr, J. W., Jamieson, J. D., Palade, G. E. Immunoglobulin synthesis and secretion. II. Radioautographic studies of sites of addition of carbohydrated moities and intracelluar transport. J. Cell. Biol. 46, 52. 1970.PubMedGoogle Scholar
  143. 143.
    Zawadzky, Z. A., Edwards, G. A. Dysimmunoglobulinemia associated with hepatobiliary disorders. Amer. J. Med. 48, 196. 1970.Google Scholar

Copyright information

© Jákó János, Budapest 1991

Authors and Affiliations

  • János Jákó
    • 1
  1. 1.1st Department of MedicinePostgraduate Medical SchoolBudapestHungary

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