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Type D Retrovirus Infection, Macaques

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Nonhuman Primates I

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

With the exception of retroperitoneal fibromatosis, subcutaneous fibrosarcomas, and possibly noma, there is no gross lesion pathognomonic for type D retrovirus infection in macaques. Gross lesions vary considerably depending upon the clinical outcome of infection. Persistently viremic healthy carriers have been recognized who may have no gross lesions (Ahmed et al. 1974; Lerche et al. 1986). Some animals develop only mild illness with transient lymphadenopathy corresponding to a period of viremia from which they recover (Maul et al. 1986). Animals which are fatally infected develop a spectrum of immunologic and hematologic abnormalities that collectively are called simian acquired immunodeficiency syndrome (SAIDS) and may have a disease course ranging from 1 month to several years (Fine et al. 1975; Bryant et al. 1986a; Letvin et al. 1984; Maul et al. 1986). In animals dying acutely, weight loss, splenomegaly, and lymphadenopathy are the most consistent lesions. Pallor due to anemia is common and purpura due to thrombocytopenia may also be seen.

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Authors
  1. Linda J. Lowenstine
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Editors and Affiliations

  1. ILSI Research Foundation, Harvard Medical School, 1126 Sixteenth Street, N.W., Washington, DC, 20036, USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology Emeritus) (Professor of Comparative Pathology Emeritus)

  2. Institut für Experimentelle Pathologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Strasse 8, 30625, Hannover, Federal Republic of Germany

    Ulrich Mohr M.D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

  3. New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA, 01772, USA

    Ronald Duncan Hunt D.V.M. (Professor of Comparative Pathology) (Professor of Comparative Pathology)

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Lowenstine, L.J. (1993). Type D Retrovirus Infection, Macaques. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Nonhuman Primates I. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84906-0_3

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