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What Changes Drug Metabolism in the Critically Ill?

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine 1993

Part of the book series: Yearbook of Intensive Care and Emergency Medicine 1993 ((YEARBOOK,volume 1993))

  • 121 Accesses

Abstract

The critically ill are exposed to many drugs, including sedatives, inotropes, analgesics and antibiotics [1]. Drug prescription in the critically ill is usually based on dose regimens extrapolated from data obtained from healthy volunteers or animals [2,3]. They form a heterogenous group with varying severity of disease, chronicity and cause. Drug metabolism is altered significantly in these patients [2,4]. Little is known about the causes of these changes although many factors may participate (Fig. 1).

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Authors
  1. M. E. O’Meara
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  2. A. J. M. Woodrooffe
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  3. G. R. Park
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1993 Springer-Verlag Berlin Heidelberg

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O’Meara, M.E., Woodrooffe, A.J.M., Park, G.R. (1993). What Changes Drug Metabolism in the Critically Ill?. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1993. Yearbook of Intensive Care and Emergency Medicine 1993, vol 1993. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84904-6_31

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  • DOI: https://doi.org/10.1007/978-3-642-84904-6_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56463-8

  • Online ISBN: 978-3-642-84904-6

  • eBook Packages: Springer Book Archive

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