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The Pathophysiology of Neuromuscular Weakness: Potential of Treatment with Growth Factors

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine 1993

Part of the book series: Yearbook of Intensive Care and Emergency Medicine 1993 ((YEARBOOK,volume 1993))

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Abstract

Hippocrates [1] observed many centuries ago that physicians were unable to differentiate the causes of skeletal muscle weakness, which is well recognized as a complication of acute and chronic illness and may seriously hamper recovery. Recent studies suggest that growth hormone (GH) and insulin like growth factor 1 (IGF-1) may ameliorate some of the catabolic changes seen in the critically ill [2]. This chapter reviews the pathophysiologic basis of skeletal muscle weakness in the critically ill, and will discuss the potential of GH and IGF-1 to act as anabolic agents in this patient group.

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Authors
  1. J. H. Coakley
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  2. G. D. Yarwood
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  3. R. J. M. Ross
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1993 Springer-Verlag Berlin Heidelberg

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Coakley, J.H., Yarwood, G.D., Ross, R.J.M. (1993). The Pathophysiology of Neuromuscular Weakness: Potential of Treatment with Growth Factors. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1993. Yearbook of Intensive Care and Emergency Medicine 1993, vol 1993. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84904-6_17

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  • DOI: https://doi.org/10.1007/978-3-642-84904-6_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-56463-8

  • Online ISBN: 978-3-642-84904-6

  • eBook Packages: Springer Book Archive

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