Invasive Aspergillosis: Host Defenses
Though species of Aspergillus are among the most common fungi in the environment, invasive aspergillosis is extremely rare in immunocompetent individuals. The small conidia of these ubiquitous organisms are inhaled frequently. However, progressive infections ensue only if conditions permit these conidia to survive, shed their outermost coatings of hydrophobic rodlet-like structures, then swell and ultimately germinate, and grow as potentially pathogenic mycelia. Thus, host defense mechanisms can prevent invasive aspergillosis by killing or blocking the transition and growth of any one of these sequential phases in morphogenesis (Levitz and Diamond 1984; Rinaldi 1983; Waldorf 1986; Schaffner et al. 1982).
KeywordsInvasive Aspergillosis Aspergillus Fumigatus Chronic Granulomatous Disease Fungicidal Activity Pulmonary Invasive Aspergillosis
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