Abstract
In recent multiparameter studies, ultrastructural morphology and cytochemistry of undifferentiated or minimally differentiated acute leukemia’s have been investigated (Lee et al. 1987; Matutes et al. 1988; Campana et al. 1990; Van Wering et al. 1990; Heil et al. 1991). Detection of myeloperoxidase (MPO) and platelet peroxidase (PPO) at the ultrastructural level appeared to be useful for myeloid leukemia’s (Bennett et al. 1991) and supportive for the diagnosis of megakaryocytic leukemias (Breton-Gorius et al. 1978; Bennett et al. 1985). We investigated 12 light-microscopically unclassifiable acute childhood leukemia’s by immunological marker analysis and by electron microscopy (EM), including peroxidase cytochemistry. The combined results appeared to provide information to diagnose conclusively cases of minimally differentiated acute myeloid leukemia’s (AML M0; Bennett et al. 1991) and acute megakaryoblastic leukemia (AML M7; Bennett et al. 1985).
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van Wering, E.R., Brederoo, P., van Staalduinen, G.J., van der Meulen, J., van der Linden-Schrever, B.E.M., van Dongen, J.J.M. (1993). Contribution of Electron Microscopy to the Classification of Minimally Differentiated Acute Leukemias in Children. In: Ludwig, WD., Thiel, E. (eds) Recent Advances in Cell Biology of Acute Leukemia. Recent Results in Cancer Research, vol 131. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84895-7_8
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DOI: https://doi.org/10.1007/978-3-642-84895-7_8
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