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Expression of B-Cell-Associated Antigens During B-Cell Ontogeny

  • Conference paper
Book cover Recent Advances in Cell Biology of Acute Leukemia

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 131))

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Abstract

The development of the B-cell lineage from stem cells to mature B lymphocytes and antibody-secreting plasma cells is a multistep process of differentiation. Stages of B-cell maturation have been characterized by the rearrangement and expression of the immunoglobulin (Ig) genes, by surface markers, and by susceptibilities to growth and differentiation factors (Tonegawa 1983; Alt et al. 1986; Campana et al. 1985; Loken et al. 1987; Kishimoto 1987; Cooper 1987). B-lineage acute lymphoblastic leukemia’s are presumed to result from leukemogenic events that occur in progenitor B cells during early phases of B-cell ontogeny and lead to a maturational arrest at discrete stages of early B-cell differentiation (Greaves 1986). Recently published data on molecular components of the B-cell antigen receptor complex, molecules selectively expressed in pre-B cells, and B-lineage- associated differentiation antigens have provided a new insight into early B-cell development, and this will contribute to a better understanding of the cell biology of B-lineage acute lymphoblastic leukemia’s.

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  1. Dep. of Medical Oncology and Tumor Immunology, URKV, Free University of Berlin, O-1115, Berlin, Fed. Rep. of Germany

    B. Dörken

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  1. B. Dörken
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  1. Abt. Hämatologie/Onkologie, Universitätsklinikum Steglitz, Hindenburgdamm 30, W-1000, Berlin 45, Germany

    Wolf-Dieter Ludwig  & Eckhard Thiel  & 

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© 1993 Springer-Verlag Berlin · Heidelberg

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Dörken, B. (1993). Expression of B-Cell-Associated Antigens During B-Cell Ontogeny. In: Ludwig, WD., Thiel, E. (eds) Recent Advances in Cell Biology of Acute Leukemia. Recent Results in Cancer Research, vol 131. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84895-7_2

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  • DOI: https://doi.org/10.1007/978-3-642-84895-7_2

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  • Print ISBN: 978-3-642-84897-1

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