Expression of B-Cell-Associated Antigens During B-Cell Ontogeny

  • B. Dörken
Conference paper
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 131)


The development of the B-cell lineage from stem cells to mature B lymphocytes and antibody-secreting plasma cells is a multistep process of differentiation. Stages of B-cell maturation have been characterized by the rearrangement and expression of the immunoglobulin (Ig) genes, by surface markers, and by susceptibilities to growth and differentiation factors (Tonegawa 1983; Alt et al. 1986; Campana et al. 1985; Loken et al. 1987; Kishimoto 1987; Cooper 1987). B-lineage acute lymphoblastic leukemia’s are presumed to result from leukemogenic events that occur in progenitor B cells during early phases of B-cell ontogeny and lead to a maturational arrest at discrete stages of early B-cell differentiation (Greaves 1986). Recently published data on molecular components of the B-cell antigen receptor complex, molecules selectively expressed in pre-B cells, and B-lineage- associated differentiation antigens have provided a new insight into early B-cell development, and this will contribute to a better understanding of the cell biology of B-lineage acute lymphoblastic leukemia’s.


Acute Lymphoblastic Leukemia Light Chain Expression Cytoplasmic CD22 Common Acute Lymphoblastic Leukemia Antigen Antigen Receptor Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin · Heidelberg 1993

Authors and Affiliations

  • B. Dörken
    • 1
  1. 1.Dep. of Medical Oncology and Tumor Immunology, URKVFree University of BerlinBerlinFed. Rep. of Germany

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