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Recent Advances in Cell Biology of Acute Leukemia pp 133–148Cite as

Chromosomal Abnormalities in Adult Acute Lymphoblastic Leukemia: Results of the German ALL/AUL Study Group

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 131))

Abstract

The clinical and biologic significance of chromosomal aberrations has rendered cytogenetic investigations an indispensable tool in the diagnosis of acute lymphoblastic leukemia (ALL) (Seeker-Walker 1990; Pui et al. 1990b). Among the chromosomal changes in adult ALL, the Ph translocation and the translocation t(4;11) are consistently found, and have been shown to identify patients with an extremely unfavorable prognosis. Moreover, the presence of any karyotypic alteration in adult ALL seems to imply a poor treatment outcome than in patients without chromosomal changes (Bloomfield et al. 1986, 1989). Therefore, not only the assessment of the frequency of well-known chromosomal rearrangements but also the identification of other karyotypic abnormalities is required, and the biologic and clinical importance of the cytogenetic findings must be evaluated in relation to clinical, morphologic, and immunologic parameters. In this report on chromosomal aberrations in adult ALL, some of these aspects will be touched upon within a discussion of specific chromosomal aberrations, including the possible significance of certain secondary aberrations in Ph- positive ALL.

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Authors and Affiliations

  1. AG Tumorcytogenetik, Institut für Humangenetik, Medizinische Universität zu Lübeck, Ratzeburger Allee 160, W-2400, Lübeck, Fed. Rep. of Germany

    H. Rieder & C. Fonatsch

  2. Abteilung für Innere Medizin, m.S. Hämatologie und Onkologie, Universitätsklinikum Steglitz, Hindenburgdamm 30, W-1000, Berlin 45, Fed. Rep. of Germany

    W.-D. Ludwig & E. Thiel

  3. II. Medizinische Universitäts- und Poliklinik, Chemnitzstr. 33, W-2300, Kiel 1, Fed. Rep. of Germany

    W. Gassmann & H. Löffler

  4. Abteilung für Hämatologie, Zentrum der Inneren Medizin, Theodor-Stern-Kai 7, W-6000, Frankfurt am Main 70, Fed. Rep. of Germany

    D. Hoelzer

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  1. H. Rieder
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  2. W.-D. Ludwig
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  3. W. Gassmann
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  4. E. Thiel
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  5. H. Löffler
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  6. D. Hoelzer
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  7. C. Fonatsch
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Editors and Affiliations

  1. Abt. Hämatologie/Onkologie, Universitätsklinikum Steglitz, Hindenburgdamm 30, W-1000, Berlin 45, Germany

    Wolf-Dieter Ludwig  & Eckhard Thiel  & 

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© 1993 Springer-Verlag Berlin · Heidelberg

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Rieder, H. et al. (1993). Chromosomal Abnormalities in Adult Acute Lymphoblastic Leukemia: Results of the German ALL/AUL Study Group. In: Ludwig, WD., Thiel, E. (eds) Recent Advances in Cell Biology of Acute Leukemia. Recent Results in Cancer Research, vol 131. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84895-7_13

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  • DOI: https://doi.org/10.1007/978-3-642-84895-7_13

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  • Online ISBN: 978-3-642-84895-7

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