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The Time Factor for Late Reactions in Radiotherapy: Repopulation or Intracellular Repair?

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Acute and Long-Term Side-Effects of Radiotherapy

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 130))

Abstract

When doses in radiotherapy are protracted over increasing periods of time, it is generally considered that very little extra dose is required (the time factor) to reach tolerance for late reactions. This is in contrast to repopulation in early-reacting tissues and in tumors (e.g., Withers et al. 1988). Nevertheless, time factors have been reported for late-reacting tissues, and even small values could sometimes be more important than in the cases of early-reacting normal tissues and tumors because of the greater steepness of dose-incidence curves for injury in late-reacting organs (e.g., Thames et al. 1989; Hendry 1989).

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Authors and Affiliations

  1. Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, M20 9BX, Manchester, UK

    J. H. Hendry & Y.-M. Jen

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  1. J. H. Hendry
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  2. Y.-M. Jen
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Editors and Affiliations

  1. Abteilung Strahlentherapie, Radiologische Universitätsklinik, Hugstetter Strasse 55, W-7800, Freiburg, Germany

    Wolfgang Hinkelbein , Gregor Bruggmoser  & Hermann Frommhold ,  & 

  2. Abteilung Radiologie, Radiologische Universitätsklinik, Im Neuenheimer Feld 400, W-6900, Heidelberg, Germany

    Michael Wannenmacher

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© 1993 Springer-Verlag Berlin · Heidelberg

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Hendry, J.H., Jen, YM. (1993). The Time Factor for Late Reactions in Radiotherapy: Repopulation or Intracellular Repair?. In: Hinkelbein, W., Bruggmoser, G., Frommhold, H., Wannenmacher, M. (eds) Acute and Long-Term Side-Effects of Radiotherapy. Recent Results in Cancer Research, vol 130. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84892-6_2

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  • DOI: https://doi.org/10.1007/978-3-642-84892-6_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84894-0

  • Online ISBN: 978-3-642-84892-6

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