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Transforming Growth Factor Regulation of Keratinocyte Growth

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Skin Carcinogenesis in Man and in Experimental Models

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 128))

Abstract

Transforming growth factors (TGF) were originally defined by their ability to induce morphologic transformation in monolayer culture and stimulate soft agar growth of rodent fibroblast cell lines (DeLarco and Todaro 1978; Moses et al. 1981; Roberts et al. 1981). Early studies with TGF indicated that they may play a role in neoplastic transformation and led to the purification and cloning of two very important growth regulatory molecules, TGF-α and TGF-β.

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Author notes

  1. J. A. Pietenpol

    Present address: Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD, 21231, USA

Authors and Affiliations

  1. Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA

    L. Dagnino, J. A. Pietenpol, E. Y. Yang & H. L. Moses

Authors
  1. L. Dagnino
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  2. J. A. Pietenpol
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  3. E. Y. Yang
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  4. H. L. Moses
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Editor information

Editors and Affiliations

  1. Division: Mechanisms of Tumorigenesis, Research Program 3: Risk Factors of Cancer and Cancer Prevention, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, W-6900, Heidelberg, Germany

    Erich Hecker

  2. Department of Dermatology, Mannheim Medical School, University of Heidelberg, Postfach 10 80 23, Theodor-Kutzer-Ufer, W-6800, Mannheim, Germany

    E. G. Jung (Director) (Director)

  3. Division: Biochemistry of Tissue Specific Regulation, Research Program 2: Tumor Cell Regulation, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, W-6900, Heidelberg, Germany

    F. Marks

  4. Department of Dermatology, University of Heidelberg, Voss-Str. 2, W-6900, Heidelberg, Germany

    W. Tilgen

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© 1993 Springer-Verlag Berlin · Heidelberg

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Dagnino, L., Pietenpol, J.A., Yang, E.Y., Moses, H.L. (1993). Transforming Growth Factor Regulation of Keratinocyte Growth. In: Hecker, E., Jung, E.G., Marks, F., Tilgen, W. (eds) Skin Carcinogenesis in Man and in Experimental Models. Recent Results in Cancer Research, vol 128. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84881-0_2

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  • DOI: https://doi.org/10.1007/978-3-642-84881-0_2

  • Publisher Name: Springer, Berlin, Heidelberg

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  • Online ISBN: 978-3-642-84881-0

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