Abstract
Hyperlipidemia is recognized as a major risk factor for atherosclerosis. In plasma lipids are carried by lipoproteins. The metabolism of these lipoproteins is dependent upon the interaction of their protein constituents, the apolipoproteins, with a variety of enzymes and receptors present in plasma or on the surface of cells in different organs and tissues. The level of expression of the genes coding for proteins involved in lipoprotein metabolism largely determines the metabolic fate of-plasma lipoproteins. The major goal of these studies was to define the discrete regulation of these genes by a number of hormones known to affect lipoprotein metabolism such as estrogens, thyroid hormones and glucocorticoids. At the same time, we have explored whether changes in gene expression are paralleled by changes in the concentration or activity of the proteins involved.
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© 1993 Springer-Verlag Berlin Heidelberg
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Staels, B., Auwerx, J. (1993). Hormonal Control of Genes Involved in Lipoprotein Metabolism in the Rat. In: Steinmetz, A., Schneider, J., Kaffarnik, H. (eds) Hormones in Lipoprotein Metabolism. Recent Developments in Lipid and Lipoprotein Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84855-1_2
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DOI: https://doi.org/10.1007/978-3-642-84855-1_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-55995-5
Online ISBN: 978-3-642-84855-1
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