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The Pathogenicity of Human Cytomegalovirus: An Overview

  • Chapter
Molecular Aspects of Human Cytomegalovirus Diseases

Part of the book series: Frontiers of Virology ((FRVIROLOGY,volume 2))

Summary

Defining causality between an agent- be it a virus, bacteria, or chemical — and a disease is the principal aim of biomedical research. Achievement of this lofty goal is hampered when the suspected agent is commonly found in the environment or in populations. Such is the case with human cytomegalovirus (HCMV). Its ubiquity diminishes the impact of its omnipresentation in many pathologies. Despite this lack of a direct cause-effect pattern between HCMV and most of the diseases it is associated with, the application of molecular biology technology has permitted us to begin to define basic underlying mechanisms by which this virus can influence, as well as cause, disease. Much of this chapter is an initial attempt at discerning important molecular biological features of HCMV which have the potential to play significant roles in the pathogenicity and oncogenicity of this virus. In so doing, patterns emerge between HCMV molecular biology and the types of pathological phenomena this virus is associated with directly or as a coetiological agent. Common themes include induction of transcriptional activators and the cell cycle, production of specific cytokines by HCMV infection, and hampering host immunities. The latter part of this chapter reviews many of the diseases and clinical features of HCMV infections. Both sections cross-reference subsequent chapters in this volume where more detailed analyses of these particular issues are provided.

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References

  1. Ahlfors K, Harris S, Ivarsson S, Svanberg L (1981) Secondary maternal cytomegalovirus infection causing symptomatic congenital infection. N Engl J Med 305: 284

    PubMed  CAS  Google Scholar 

  2. Albrecht T, Fons MP, Boldogh I, AbuBakar S, Deng CZ, Millinoff D (1991) Metabolic and cellular effects of human cytomegalovirus infection. Transplant Proc 23 [Supp] 31: 48–55

    Google Scholar 

  3. Albrecht T, Rapp F (1973) Malignant transformation of hamster embryo fibroblasts following exposure to ultraviolet-irradiate human cytomegalovirus. Virology 55: 53–61

    PubMed  CAS  Google Scholar 

  4. Alcami J, Barzu T, Michelson S (1991) Induction of an endothelial cell growth factor by human cytomegalovirus infection of fibroblasts. J Gen Virol 72: 2765–2770

    PubMed  CAS  Google Scholar 

  5. Alexander ER (1967) Maternal and neonatal infection with cytomegalovirus in Taiwan. Pediatr Res 1: 210

    Google Scholar 

  6. Alford CA Jr, Britt WJ (1990) Cytomegalovirus. In: Fields B et al. (eds) Virology, 2nd edn. New York

    Google Scholar 

  7. Andersen HK, Spenser ES (1969) Cytomegalovirus infection among renal allograft recipients. Acta Med Scand 186: 7–19

    PubMed  CAS  Google Scholar 

  8. Baeuerle PA (1991) The inducible transcription activator NF-xB: regulation by distinct protein subunit. Biochim Biophys Acta 1072: 63–80

    PubMed  CAS  Google Scholar 

  9. Baeuerle PA, Baltimore D (1988) IxB: a specific inhibitor of the NF-xB transcription factor. Science 242: 540–546

    PubMed  CAS  Google Scholar 

  10. Bandara LR, Adamaczewski JP, Hunt T, LaThangue NB (1991) Cyclin A and the retinoblastoma gene product complex with cellular transcription factor. Nature 352: 249–251

    PubMed  CAS  Google Scholar 

  11. Beck S, Barrell BG (1988) Human cytomegalovirus encodes a glycoprotein homologous to MHC class I antigens. Nature 331: 269–272

    PubMed  CAS  Google Scholar 

  12. Benson JD, Huang ES (1990) Human cytomegalovirus induces expression of cellular topoisomerase II. J Virol 64: 9–15

    PubMed  CAS  Google Scholar 

  13. Boldogh I, AbuBakar S, Albrecht T (1990) Activation of proto-oncogenes: an immediate early event in human cytomegalovirus infection. Science 247: 561–564

    PubMed  CAS  Google Scholar 

  14. Boldogh I, Baskar JF, Mar EC, Huang ES (1983) Human cytomegalovirus and herpes simplex type 2 virus in normal and adenocarcinomatous prostate glands. J Natl Cancer Inst 70: 819–825

    PubMed  CAS  Google Scholar 

  15. Boldogh I, Beth E, Huang ES, Kyalwazi KS, Giraldo G (1981) Kaposi’s sarcoma: IV. Detection of CMV DNA, CMV RNA and CMNA in tumor biopsies. Int J Cancer 28: 469–474

    PubMed  CAS  Google Scholar 

  16. Boldogh I, Gonczol E, Vaczi L (1978) Transformation of hamster embryonic fibroblast cell by UV-irradiated human cytomegalovirus. Acta Microbiol Hung 25: 269–275

    CAS  Google Scholar 

  17. Borysiewicz LK, Graham S, Hickling JK, Mason PD, Sissons JG (1988) Human cytomegalovirus specific cytotoxic T cells: their precursor frequency and stage specificity. Eur J Immunol 18: 269–275

    PubMed  CAS  Google Scholar 

  18. Borysiewicz LK, Hickling JK, Graham S, Sinclair J, Cranage MP, Smith GL, Sissons JG (1988) Human cytomegalovirus-specific cytotoxic T cells. Relative frequency of stage-specific CTL recognizing the 72-kD immediate early protein and glycoprotein B expressed by recombinant vaccinia viruses. J Exp Med 168: 919–931

    PubMed  CAS  Google Scholar 

  19. Boshart M, Weber F, Jahn G, Dorsch-Hasler K, Fleckenstein B, Schaffner W (1985) A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus. Cell 41: 521–530

    PubMed  CAS  Google Scholar 

  20. Brasfield DM, Stagno S, Whitley RJ, Cloud G, Cassell G, Tiller RE (1987) Infant pneumonitis associated with cytomegalovirus, chlamydia, pneumocystis, and ureaplasma: follow-up. Pediatrics 79: 76–83

    PubMed  CAS  Google Scholar 

  21. Britt WJ (1991) Recent advanced in the identification of significant human cytomegalovirus-encoded proteins. Transplant Proc 23 [Suppl 3]: 64–68

    PubMed  CAS  Google Scholar 

  22. Britt WJ, Auger D (1986) Human cytomegalovirus virion-associated protein with kinase activity. J Virol 59: 185–188

    PubMed  CAS  Google Scholar 

  23. Browne H, Smith G, Beck S, Minson T (1990) A complex between MHC class I homologue encoded by human cytomegalovirus and beta 2-microglobulin. Nature 347: 770–772

    PubMed  CAS  Google Scholar 

  24. Cai W, Gu B, Person S (1988) Role of glycoprotein B of herpes simplex virus type 1 in viral entry and cell fusion. J Virol 62: 2596–2604

    PubMed  CAS  Google Scholar 

  25. Careny WP, Lacoviello V, Hirsch MS (1983) Functional properties of T lymphocytes and their subsets in cytomegalovirus mononucleosis. J Immunol 130: 390–393

    Google Scholar 

  26. Carney WP, Rubin RH, Hoffman RA, Hansen WP, Healey K, Hirsch MS (1981) Analysis of T lymphocyte subsets in cytomegalovirus mononucleosis. J Immunol 126: 2114–2116

    PubMed  CAS  Google Scholar 

  27. Chee MS, Bankier AT, Beck S, Bohni R, Brown CM, Cerny R, Horsnell T, Hutchison CA III, Kouzarides T, Martignetti JA, Preddie E, Satchwell SC, Tomlinson P, Weston KM, Barrell BG (1990) Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169. Curr Top Microbiol Immunol 154: 125–169

    PubMed  CAS  Google Scholar 

  28. Chee MS, Satchwell SC, Preddie E, Weston KM, Barrell BG (1990) Human cytomegalovirus encodes three G protein-coupled receptor homologues. Nature 344: 774–777

    PubMed  CAS  Google Scholar 

  29. Chellappan SP, Hiebert S, Mudryj M, Horowitz JM, Nevins JR (1991) The E2F transcription factor is a cellular target for the RB protein. Cell 65: 1053–1061

    PubMed  CAS  Google Scholar 

  30. Clanton DJ, Jariwalla RJ, Kress C, Rosenthal LJ (1983) Neoplastic transformation by a cloned human cytomegalovirus DNA fragment uniquely homologous to one of the transforming regions of herpes simplex virus type 2. Proc Natl Acad Sci USA 80: 3826–3830

    PubMed  CAS  Google Scholar 

  31. Contreras TJ, Lang DJ, Pivacek LE, Valeri CR (1979) Occurrence of HBsAg, anti-HBs, and anti-CMV following the transfusion of blood products. Transfusion 19: 129–136

    PubMed  CAS  Google Scholar 

  32. Cole R, Kuttner AG (1926) A filterable virus present in the submaxillary glands of guinea pigs. J Exp Med 44: 855–873

    PubMed  CAS  Google Scholar 

  33. Cooper NR, Nowlin D, Taylor HP, Compton T (1991) Cellular receptor for human cytomegalovirus. Transplant Proc 23 [Suppl 3]: 56–59

    PubMed  CAS  Google Scholar 

  34. Cowdry EV (1934) The problem of intranuclear inclusion in virus disease. Arch Pathol 18: 525–542

    Google Scholar 

  35. Dalgleish AG, Beverley PC, Clapham PR, Crawford DH, Greaves MF, Weiss RA (1984) The CD4 ( T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312: 763–767

    PubMed  CAS  Google Scholar 

  36. Davis MG, Huang ES (1985) Nucleotide sequence of a human cytomegalovirus DNA fragment encoding a 67-kilodalton phosphorylated viral protein. J Virol 56: 7–11

    PubMed  CAS  Google Scholar 

  37. Davis MG, Huang ES (1987) Dissection of the regulatory functions of the immediate early region of human cytomegalovirus. Abstract, p 4. Twelfth International Herpes Workshop, Philadelphia, PA. July 30 — August 4, 1987

    Google Scholar 

  38. Davis MG, Kenney SC, Kamine J, Pagano JS, Huang ES (1987) Immediate-early gene region of human cytomegalovirus transactivates the promoter of human immunodeficiency virus. Proc Natl Acad Sci USA 84: 8642–8646

    PubMed  CAS  Google Scholar 

  39. Davis MG, Mar EC, Wu YM, Huang ES (1984) Mapping and expression of a human cytomegalovirus major viral protein. J Virol 52: 129–135

    PubMed  CAS  Google Scholar 

  40. Deen KC, Mcdougal JS, Inacker R, Folena-Wasserman G, Arthos J, Rosenberg J, Madden PJ, Axel R, Sweet RW (1988) A soluble form of CD ( T4) protein inhibits AIDS virus infection. Nature 331: 82–84

    PubMed  CAS  Google Scholar 

  41. Devoto SH, Mudryj M, Pines J, Hunter T, Nevins JR (1992) A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33od1c2 is a component of the E2F-cyclin A complex. Cell 68: 167–176

    PubMed  CAS  Google Scholar 

  42. Drew WL, Conant MA, Miner RC, Huang ES, Ziegler JL, Groundwater JR, Gullett JH, Volberding P, Abrams DI, Mintz L (1982) Cytomegalovirus and Kaposi’s sarcoma in young homosexual men. Lancet 2: 125–127

    PubMed  CAS  Google Scholar 

  43. Drew WL, Huang ES (1988) Etiology: role of cytomegalovirus. In: Ziegler JL, Dorfman RF (eds) Kaposi’s sarcoma. Dekker, New York, pp 113–128

    Google Scholar 

  44. Drew WL, Mintz L, Miner RC, Sands M, Ketterer B (1981) Prevalence of cytomegalovirus in homosexual men. J Infect Dis 143: 188–192

    PubMed  CAS  Google Scholar 

  45. Drew WL, Mocarski ES, Sweet E, Miner RC (1984) Multiple infections with CMV in AIDS patients: documentation by southern blot hybridization. J Infect Dis 150: 952–953

    PubMed  CAS  Google Scholar 

  46. Dudding L, Haskill S, Clark BD, Auron PE, Sporn S, Huang ES (1989) Cytomegalovirus infection stimulates expression of monocyte-associated mediator genes. J Immunol 143: 3343–3352

    PubMed  CAS  Google Scholar 

  47. Duh EJ, Maury WJ, Folks TM, Fauci AS, Rabson AB (1989) Tumor necrosis factor alpha activates human immunodeficiency virus-type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat. Proc Natl Acad Sci USA 86: 5964–5978

    Google Scholar 

  48. Durst M, Gissmann L, Ikenberg H, zur Hausen H (1983) A papilloma DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Natl Acad Sci USA 80: 3812–3815

    PubMed  CAS  Google Scholar 

  49. Dyck PJ, Lambert EH (1968) Lower motor and primary sensory neuron diseases with peroneal muscular atropy (part I and II). Arch Neurol 18: 603–625

    PubMed  CAS  Google Scholar 

  50. Embil JA, Ozere RL, Haldane EV (1970) Congenital cytomegalovirus infection in two siblings from consecutive pregnancies. J Pediatr 77: 417–421

    PubMed  CAS  Google Scholar 

  51. Ensoli B, Barillari G, Salahuddin SZ, Gallo RC, Wong-Staal F (1990) Tat protein of HIV-1 stimulates growth of cells derived from Kaposi’s sarcoma lesions of AIDS patients. Nature 345: 84–86

    PubMed  CAS  Google Scholar 

  52. Estes JE, Huang ES (1977) Stimulation of cellular thymidine kinases by human cytomegalovirus. J Virol 24: 13–21

    PubMed  CAS  Google Scholar 

  53. Fan CM, Maniatis T (1991) Generation of p50 subunit of NF-xB by processing of p105 through an ATP-dependent pathway. Nature 354: 395–398

    PubMed  CAS  Google Scholar 

  54. Farber S, Wolbach SG (1932) Intranuclear and cytoplasmic inclusions (“protozoan-like bodies”) in the salivary glands and other organs of infants. Am J Pathol 8: 123–135

    PubMed  CAS  Google Scholar 

  55. Fetterman GH (1952) A new laboratory aid in the clinical diagnosis of inclusion disease of infancy. Am J Clin Pathol 22: 424–425

    PubMed  CAS  Google Scholar 

  56. Fiala M, Kattlove H, Lemkin T (1973) Cytomegalovirus mononucleosis with severe thrombocytopenia. Ann Intern Med 79: 450–451

    PubMed  CAS  Google Scholar 

  57. Finkle C, Tapper MA, Knox KK, Carrigan DR (1991) Coinfection of cells with the human immunodeficiency virus and cytomegalovirus in lung tissues of patients with AIDS. J Acquir Immune Defic Syndr 4: 735–737

    PubMed  CAS  Google Scholar 

  58. Fisher RA, Bertonis JM, Meier W, Johnson VA, Costopoulos DS, Liu T, Tizard R, Walker BD, Hirsch MS, Schooley RT et al. (1988) HIV infection is blocked in vitro by recombinant soluble CD4. Nature 331: 76–78

    Google Scholar 

  59. Folks TM, Justement J, Kinter A, Dinarello CA, Fauci AS (1987) Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line. Science 238: 800–802

    PubMed  CAS  Google Scholar 

  60. Forman SJ (1991) Bone marrow transplantation. Transplant Proc 23 [Suppl 3]: 110–114

    PubMed  CAS  Google Scholar 

  61. Foster KM (1966) Post-transfusion mononucleosis. Aust Ann Med 15: 305–310

    PubMed  CAS  Google Scholar 

  62. Frenkel LD, Gaur S, Tsolia M, Scudder R, Howell R, Kesarwala H (1990) Cytomegalovirus infection in children with AIDS. Rev Infect Dis 12 [Suppl 7]: S820–826

    PubMed  Google Scholar 

  63. Fujinami RS, Nelson JA, Walker L, Oldstone MBA (1988) Sequence homology and immunologic cross-reactivity of human cytomegalovirus with HLA-DR B chain: a means for graft rejection and immunosuppression. J Virol 62: 100–105

    PubMed  CAS  Google Scholar 

  64. Geder L, Lausch R, O’Neill F, Rapp F (1976) Oncogenic transformation of human embryo lung cells by cytomegalovirus. Science 192: 1134–1137

    PubMed  CAS  Google Scholar 

  65. Gehrz RC, Liu YNC, Eckhardt J, Klaus A (1991) Relevance of immune responses to pathogenesis of cytomegalovirus associated diseases. Transplant Proc 23 [Suppl 3]: 55–84

    Google Scholar 

  66. Gehrz RC, Marker SC, Knoor SO, Kalis JM; Balfour HH Jr (1977) Specific cell-mediated immune defect in active cytomegalovirus infection of young children and their mothers. Lancet 2: 844–847

    PubMed  CAS  Google Scholar 

  67. Ghosh S, Baltimore D (1990) Activation in vitro of NF-xB by phosphorylation of its inhibitor IkB. Nature 344: 678–682

    PubMed  CAS  Google Scholar 

  68. Gilmore T (1990) NF-xB, KBF1, dorsal and rel-related matters. Cell 62: 841–843

    PubMed  CAS  Google Scholar 

  69. Giraldo G, Beth E, Henle W, Henle G, Mike V, Safai B, Huraux JM, McHardy J, de-The G (1980) Antibody patterns to herpesvirus in Kaposi’s sarcoma: II. Serological association of American Kaposi’s sarcoma with cytomegalovirus. Int J Cancer 22: 126–131

    Google Scholar 

  70. Giraldo G, Beth E, Huang ES (1980) Kaposi’s sarcoma and its relationship to cytomegalovirus (CMV): III. CMV DNA and CMV early antigens in Kaposi’s sarcoma. Int J Cancer 26: 23–29

    PubMed  CAS  Google Scholar 

  71. Gissmann L, Wolnick L, Ikenberg H, Koldenovsky U, Schurch HG, zur Hausen H (1983) Human papilloma type 6 and 11. DNA sequence in genital and laryngeal papilloma and in some cervical cancers. Proc Natl Acad Sci USA 80: 560–563

    PubMed  CAS  Google Scholar 

  72. Goldstein SC, Byrne JC, Rabson AS (1987) Human cytomegalovirus (HCMV) enhance bovine papilloma virus ( BPV) transformation in vitro. J Med Virol 23: 157–164

    PubMed  CAS  Google Scholar 

  73. Gonczol E, Plotkin SA (1984) Cells infected with human cytomegalovirus release a factor(s) that stimulates cell DNA synthesis. J Gen Virol 65: 1833–1837

    PubMed  CAS  Google Scholar 

  74. Gorensek MJ, Stewart RW, Keys TF, McHenry MC, Babiak T, Goormastic M (1988) Symptomatic cytomegalovirus infection as a significant risk factor for major infections after cardiac transplantation. J Infect Dis 158: 884–887

    PubMed  CAS  Google Scholar 

  75. Gorensek MJ, Stewart RW, Keys TF, McHenry MC, Goormastic M (1988) A multivariate analysis of the risk of cytomegalovirus infection in heart transplantation recipients. J Infect Dis 157: 515–522

    PubMed  CAS  Google Scholar 

  76. Granstrom ML, Leinikki P, Santavuori P, Pettay 0 (1977) Perinatal cytomegalovirus infection in man. Arch Dis Child 52: 354–359

    CAS  Google Scholar 

  77. Grundy JE (1990) Virologie and pathologic aspects of cytomegalovirus infection. Rev Infect Dis 12 [Suppl 7]: S711 - S719

    PubMed  Google Scholar 

  78. Grundy JE, McKeating JA, Sandersom AR, Griffiths PA (1988) Cytomegalovirus and ß-2 microglobulin in urine specimens. Transplantation 45: 1075–1079

    PubMed  CAS  Google Scholar 

  79. Grundy JE, McKeating JA, Ward P, Sanderson A, Griffiths PA (1987) ß2-Microglobulin enhances the infectivity of cytomegalovirus and when bound to the virus enables class I HLA molecules to be used as a virus receptor. J Gen Virol 68: 793–803

    PubMed  CAS  Google Scholar 

  80. Grundy JE, Shanley JD, Shearer GM (1985) Augmentation of graft vs host reaction by cytomegalovirus infection resulting in interstitial pneumonitis. Transplantation 39: 548–553

    PubMed  CAS  Google Scholar 

  81. Hanshaw JB (1968) Cytomegaloviruses. In: Gard S, Hallauer C, Meyer KF (eds) Cytomegaloviruses, Rinderpest Virus, Lumpyskin Disease Virus. (Virology Monograph, Vol. 3). Springer New York, pp 1–23

    Google Scholar 

  82. Hanshaw JB (1970) Developmental abnormalities associated with congenital cytomegalovirus infection. Adv Teratol 4: 64–93

    Google Scholar 

  83. Hanshaw JB, Betts RF, Simon G, Boynton RC (1965) Acquired cytomegalovirus infection: association with hepatomegaly and abnormal liver-function tests. N Engl J Med 272: 602–609

    PubMed  CAS  Google Scholar 

  84. Hashiro GM, Horikami S, Loh PC (1979) Cytomegalovirus isolations form cell cultures of human adenocarcinomas of colon. Intervirology 12: 84–88

    PubMed  CAS  Google Scholar 

  85. Hedley-Whyte ET, Craighead JE (1965) Generalized cytomegalic inclusion disease after renal homotransplantation — report of a case with isolation of virus. N Engl J Med 272: 473–475

    PubMed  CAS  Google Scholar 

  86. Henninghausen L, Fleckenstein B (1986) Nuclear factor interacts with five DNA elements of the human cytomegalovirus major immediate early gene. EMBO J 5: 1367–1371

    Google Scholar 

  87. Hilderbrandt RJ, Sever JL, Margileth AM, Callagan DA (1967) Cytomegalovirus in the normal pregnant women. Am J Obstet Gynecol 98: 1125–1128

    Google Scholar 

  88. Ho M (1991) Cytomegalovirus: biology and infection, 2nd edn. Plenum, New York

    Google Scholar 

  89. Hohmann HP, Remy R, Aigner L, Brockhaus M, van Loon APGM (1992) Protein kinases negatively affect nuclear factor-AB activation by tumor necrosis factor-a at two different stages in promyelocytic HL60 cells. J Biol Chem 267: 2065–2072

    PubMed  CAS  Google Scholar 

  90. Homsy L, Meyer M, Tateno M, Clarkson S, Levy JA (1988) The Fc and not CD4 receptor mediates antibody enhancement of HIV infection in human cells. Science 244: 1357–1360

    Google Scholar 

  91. Horwitz CA, Henle W, Henle G (1979) Diagnostic aspects of the cytomegalovirus mononucleosis syndrome in previously healthy persons. Postgrad Med 66: 153–158

    PubMed  CAS  Google Scholar 

  92. Huang ES (1975) Human cytomegalovirus: III. Virus-induced DNA polymerase. J Virol 16: 298–310

    PubMed  CAS  Google Scholar 

  93. Huang ES, Boldogh I, Mar EC (1983) Human cytomegaloviruses: evidence for possible association with human cancer. In: Philips LA (ed) Viruses associated with human cancer. Dekker, New York, pp 161–193

    Google Scholar 

  94. Huang ES, Davis MG, Baskar JF, Huong SM (1986) Molecular epidemiology and oncogenicity of human cytomegalovirus. In: Harris CC (ed) Biochemical and molecular epidemiology of cancer. Liss, New York, pp 313–322 (UCLA symposium on molecular and cellular biology, new series, vol 40 )

    Google Scholar 

  95. a. Huang ES, Kilpatrick B, Lakeman A, Alford CA (1978) Genetic analysis of a cytomegalovirus-like agent isolated from human brain. J Virol 26: 718–723

    PubMed  CAS  Google Scholar 

  96. Huang ES, Pagano JS (1974) Human cytomegalovirus. II. Lack of relatedness to herpes simplex I and II, Epstein-Barr virus and non-human cytomegalovirus. J Virol 13: 642–645

    PubMed  CAS  Google Scholar 

  97. Huang ES, Roche JK (1978) Cytomegalovirus DNA and adenocarcinoma of the colon: evidence for latent viral infection. Lancet 1: 957–960

    PubMed  CAS  Google Scholar 

  98. Isom Hi (1979) Stimulation of ornithine decarboxylase by human cytomegalovirus. J Gen Virol 42: 265–278

    Google Scholar 

  99. Israel N, Hazan U, Alcami J, Munier A, Arenzana-Seisdedos F, Bachelerie F, Israel A (1989) Tumor necrosis factor stimulates transcription of HIV-1 in human T lymphocytes, independently and synergistically with mitogen. J Immunol 143: 3956–3960

    PubMed  CAS  Google Scholar 

  100. Ivan R, Brostoff J, Male D (1989) Chap. 4, p 8 Immunology, 2nd edn. Gower, London

    Google Scholar 

  101. Jabs DA, Engler C, Bartlett JG (1989) Cytomegalovirus retinitis and acquired immunodeficiency syndrome. Arch Ophthalmol 107: 75–80

    PubMed  CAS  Google Scholar 

  102. Jacobson MA, Mills J (1988) Serious cytomegalovirus disease in the acquired immunodeficiency syndrome (AIDS). Clinical findings, diagnosis, and treatment. Ann Intern Med 108: 585–594

    PubMed  CAS  Google Scholar 

  103. Jeang KT, Rawlins DR, Rosenfeld PJ, Shero JH, Kelley TJ, Hayward GS (1987) Multiple tandemly repeated binding sites for cellular nuclear factor 1 that surround the major immediate-early promoters of simian and human cytomegalovirus. J Virol 61: 1559–1570

    PubMed  CAS  Google Scholar 

  104. Jenson AB, Rosenberg HS, Notkins AL (1980) Pancreatic islet cell damage in children with fatal viral infection. Lancet 2: 354–358

    PubMed  CAS  Google Scholar 

  105. Jesionek A, Kiolemenoglou B (1904) Ueber einen Befund von protozoen-artigen Gebilden in den Organen eines hereditar-luetischen Foetus. Muench Med Wochenschr 15:1905–1907

    Google Scholar 

  106. Kaplan CS, Petersen EA, Icenogle TB, Copeland JG, Villar HV, Sampliner R, Minnich L, Ray CG (1989) Gastrointestinal cytomegalovirus infection in heart and heart-lung transplant recipients. Arch Intern Med 149: 2095–2100

    PubMed  CAS  Google Scholar 

  107. Keay S, Rasmussen L, Merigan TC (1988) Syngeneic monoclonal anti-idiotype antibodies that bear the internal image of a human cytomegalovirus neutralization epitope. J Immunol 140: 944–948

    PubMed  CAS  Google Scholar 

  108. Kerr LD, Inouve J, Davis N, Link E, Baeuerle PA, Bose HR, Verma IM (1991) The rel-associated pp40 protein prevents DNA binding of Rel and NF-xB: relationship with IxB-ß and regulation by phosphorylation. Genes Dev 5: 1464–1476

    PubMed  CAS  Google Scholar 

  109. Kirmani N, Ginn RK, Mittal KK, Manischewitz JF, Quinnan GV Jr (1981) Cytomegalovirus-specific cytotoxicity mediated by non-T lymphocyte from peripheral blood of normal volunteers. Infect Immun 34: 441–447

    PubMed  CAS  Google Scholar 

  110. Klatt EC, Shibata D (1988) Cytomegalovirus infection in the acquired immunodeficiency syndrome. Clinical and autopsy finding. Arch Pathol Lab Med 112: 340–344

    Google Scholar 

  111. Klemola E, Kaariainen L (1965) Cytomegalovir as a possible cause of a disease resembling infectious mononucleosis. Br J Med 2: 1099–1102

    CAS  Google Scholar 

  112. Klemola E, Kaariainen L, von Essen R, Haltia K, Koivuniemi A, von Bonsdorff CH (1967) Further studies on cytomegalovirus mononucleosis in previously healthy individuals. Acta Med Scand 182: 311–322

    PubMed  CAS  Google Scholar 

  113. Klucher KM, Rabert DK, Spector DH (1989) Sequences in the human cytomegalovirus 2.7-promoter which mediate its regulation as an early gene. J Virol 63: 5334–5343

    PubMed  CAS  Google Scholar 

  114. Kowalik TF, McKnight KL, Huang ES (1990) Human cytomegalovirus can alter human papillomavirus gene expression and cellular transformation efficiency. Abstract 311, 15th international herpesvirus workshop, Georgetown, Washington. August 2–8, 1990

    Google Scholar 

  115. Kowalik TF, McKnight KL, Huang ES (1990) Human cytomegalovirus can alter human papillomavirus gene expression and cellular transformation efficiency. Abstract 311, 15th international herpesvirus workshop, Georgetown, Washington. August 2–8, 1990

    Google Scholar 

  116. Kumar KL, Gold E, Nankervis GA (1975) Risk of acquired cytomegalovirus infection in infants of maternal CMV excretory. Pediatr Res 9: 512

    Google Scholar 

  117. Kungu A, Gates DG (1981) Kaposi’s sarcoma in Kenya: a retrospective clinicopathological study. Antibiot Chemother 29: 38–55

    PubMed  CAS  Google Scholar 

  118. Lang DJ, Hanshaw JB (1969) Cytomegalovirus infection and the post-perfusion syndrome: recognition of primary infections in four patients. N Engl J Med 280: 1145–1149

    PubMed  CAS  Google Scholar 

  119. Lang DJ, Kummer JF (1972) Demonstration of cytomegalovirus in semen. N Engl J Med 287: 756–758

    PubMed  CAS  Google Scholar 

  120. Larsen CG, Anderson AO, Appella E, Oppenheim JJ, Matsushima K (1989) The neutrophil-activating protein (NAP-1) is also chemotactic for T lymphocytes. Science 243: 1464–1466

    PubMed  CAS  Google Scholar 

  121. Lenardo MJ, Baltimore D (1989) NF-xB: a pleiotrophic mediator of inducible and tissue-specific gene control. Cell 58: 227–229

    PubMed  CAS  Google Scholar 

  122. Leonard JC, Tobin JO`H (1971) Polyneuritis associated with cytomegalovirus infections. Q J Med 40: 435–442

    Google Scholar 

  123. Levin MJ, Rinaldo CR Jr, Leary PL, Zaia JA, Hirsh MS (1979) Immune response to herpes virus antigens in adults with acute cytomegalovirus mononucleosis. J Infect Dis 140: 851–857

    PubMed  CAS  Google Scholar 

  124. Levinsohn EM, Foy HM, Kenny GE, Wentworth BB, Grayston JT (1969) Isolation of cytomegalovirus from a cohort of 100 infants throughout the first year of life. Proc Soc Exp Biol Med 132: 957–962

    PubMed  CAS  Google Scholar 

  125. a. Lin B, Stinski MF (1992) Human cytomegalovirus contains a tegument protein that enhances transcription from promoters with upstream ATF and AP-I cis-acting elements. J Virol 66: 4434–4444

    Google Scholar 

  126. b. Lindsley MD, Torpey DJ III, Rinaldo CR Jr (1986) HLA-DR-restricted cytotoxicity of cytomegalovirus-infected monocytes mediated by Leu-3-positive T cells. J Immunol 136: 3045–3051

    PubMed  CAS  Google Scholar 

  127. Lowenstein C (1907) Ueber protozoenartige Gebilde in den Organen von Kindern. Zentralbl Allg Pathol 18: 513–518

    Google Scholar 

  128. Lowenthal JW, Ballard DW, Bohnlein E, Greene WC (1989) Tumor necrosis factor alpha induces proteins that bind specifically to kappa B-like enhancer elements and regulate interleukin 2 receptor alpha-chain gene expression in primary human T lymphocytes. Proc Natl Acad Sci USA 86: 2331–2335

    PubMed  CAS  Google Scholar 

  129. Lubon H, Ghazal P, Hennighausen L, Reynolds-Kohler C, Lochshin C, Nelson JA (1989) Cell-specific activity of the modulator region in the human cytomegalovirus major immediate early gene. Mol Cell Biol 9: 1342–1345

    PubMed  CAS  Google Scholar 

  130. Mach M, Stamminger T, Gerhard J (1989) Human cytomegalovirus: recent aspects from molecular biology. J Gen Virol 70: 3117–3146

    PubMed  CAS  Google Scholar 

  131. Macher AM, Reichert CM, Strau SE, Longo DL, Parrillo J, Lane HC, Fauci AS, Rook AH, Manischewitz JF, Quinnan GV Jr (1983) Death in the AIDS patient: role of cytomegalovirus. N Engl J Med 309: 1454

    PubMed  CAS  Google Scholar 

  132. Maddon PA, Dalgleish AG, McDougal JS (1986) The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47: 333–348

    PubMed  CAS  Google Scholar 

  133. Mar EC, Patel P, Huang ES (1981) Human cytomegalovirus-associated DNA polymerase and protein kinase activities. J Gen Virol 57: 149–156

    PubMed  CAS  Google Scholar 

  134. McCracken GJ Jr, Shinefield HR, Cobb K, Rausen AR, Dische MR, Eichenwald HF (1969) Congenital cytomegalovirus inclusion disease. A longitudinal study of 20 patients. Am J Dis Child 117: 522–539

    PubMed  Google Scholar 

  135. McKeating JA, Griffiths PD, Grundy JE (1986) Cytomegalovirus in urine specimens has host beta 2 microglobulin bound to the viral envelope: a mechanism of evading the host immune response? J Gen Virol 68: 785: 792

    Google Scholar 

  136. McKeating JA, Griffiths PD, Weiss RA (1990) HIV susceptibility conferred to human fibroblasts by cytomegalovirus-induced Fc receptor. Nature 343: 659–661

    PubMed  CAS  Google Scholar 

  137. Melnick JL, Lewis R, Wimberly I, Kaufman RH, Adams E (1978) Association of cytomegalovirus (CMV) infection with cervical cancer: isolation of CMV from cell cultures derived from cervical biopsy. Intervirology 10: 115–119

    PubMed  CAS  Google Scholar 

  138. Meyers JD, Spencer HC Jr, Watts JC, Gregg MB, Stewart JA, Troupin RH, Thomas ED (1975) Cytomegalovirus pneumonia after bone marrow transplantation. Ann Intern Med 82: 181–188

    Google Scholar 

  139. Meyers JD, Flournoy N, Thomas ED (1986) Risk factors for cytomegalovirus infection after human marrow transplant. J Infect Dis 153: 478–488

    PubMed  CAS  Google Scholar 

  140. Michelson S, Tardy-Panit M, Barzu 0 (1984) Properties of a human cytomegalovirusinduced protein kinase. Virology 134: 259–268

    CAS  Google Scholar 

  141. Miles SA, Martinez-Maza O, Rezai AR, Magpantay L, Kishimoto T, Nakamura S, Radka SF, Linsley PS (1992) Oncostatin M as a potent mitogen for AIDS-Kaposi’s sarcoma-derived cells. Science 255: 1432–1434

    PubMed  CAS  Google Scholar 

  142. Miles SA, Rezai AR, Salazor-Gonzalez JF, Vander-Meyden M, Steven RH (1990) AIDS Kaposi sarcoma-derived cells produce and respond to interleukin 6 Proc Natl Acad Sci USA 87: 4068–4072

    PubMed  CAS  Google Scholar 

  143. Mintz L, Drew WL, Miner RC, Braff EH (1983) Cytomegalovirus infections in homosexual men: an epidemiological study. Ann Intern Med 99: 326–329

    PubMed  CAS  Google Scholar 

  144. a. Mocarski ES jr (1991) Initial events involved in cytomegalovirus — cell interactions. Transplant Proc 23 [Suppl 3]: 43–47

    PubMed  CAS  Google Scholar 

  145. Morgello S, Cho ES, Nielsen S, Devinsky O, Petito CK (1987) Cytomegalovirus encephalitis in patients with acquired immunodeficiency syndrome: an autopsy study of 30 cases and a review of the literature. Hum Pathol 18: 289–297

    PubMed  CAS  Google Scholar 

  146. Mudryj M, Devato SH, Hilbert SW, Hunter T, Pines J, Nevins JR (1991) Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell 65: 1243–1253

    PubMed  CAS  Google Scholar 

  147. Nabel GJ, Baltimore D (1987) An inducible transcriptional factor activates expression of human immunodeficiency virus in T cells. Nature 326: 711–713

    PubMed  CAS  Google Scholar 

  148. Nelson JA, Fleckenstein B, Galloway DA, McDougall JK (1982) Transformation of NIH 3T3 cells with cloned fragments of human cytomegalovirus strain AD169. J Virol 43: 83–91

    PubMed  CAS  Google Scholar 

  149. Nelson JA, Groudine M (1986) Transcpritional regulation of the human cytomegalovirus major immediate-early gene is associated with induction of DNase 1-hypersensitive sites. Mol Cell Biol 6: 452: 461

    Google Scholar 

  150. Nelson JA, Reynolds-Kohler C, Oldstone MBA, Wiley CA (1988) HIV and HCMV coinfect brain cells in patients with AIDS. Virology 165: 286–290

    PubMed  CAS  Google Scholar 

  151. Nelson JA, Reynolds-Kohler C, Smith BA (1987) Negative and positive regulation by a short segment in the 5’ flanking region of the human cytomegalovirus major immediate-early gene. Mol Cell Biol 7: 4125–4129

    PubMed  CAS  Google Scholar 

  152. Nevins JR (1989) Mechanisms of viral-mediated trans-activation of transcription. Adv Virus Res 37: 35–83

    PubMed  CAS  Google Scholar 

  153. Nicholas J, Cameron KR, Honess RW (1992) Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins. Nature 355: 362–365

    PubMed  CAS  Google Scholar 

  154. Numazaki K, Goldman H, Wong I, Wainberg MA (1988) Viral infection of human islets of Langerhans. Replication of human cytomegalovirus in cultured human fetal pancreatic islets. Am J Clin Pathol 90: 52–57

    PubMed  CAS  Google Scholar 

  155. Numazaki Y, Yano N, Morizuka T, Takai S, Ishida N (1970) Primary infection with human cytomegalovirus: virus isolation from healthy infants and pregnant women. Am J Epidemiol 91: 410–417

    PubMed  CAS  Google Scholar 

  156. Osborn L, Kunkel S, Nabel GL (1989) Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. Proc Natl Acad Sci USA 86: 2336–2340

    PubMed  CAS  Google Scholar 

  157. Pagano JS, Huang ES (1976) Application of RNA-DNA cytohybridization to viral diagnosis. In: Kurstak E, Morrisset T (eds) Comparative immunodiagnosis of viral infection. Academic, New York, pp 279–299

    Google Scholar 

  158. Pak CY, McArthur RG, Eun HM, Yoon JW (1988) Association of cytomegalovirus infection with autoimmune type 1 diabetes. Lancet 1: 4

    Google Scholar 

  159. Pass RF, Dworsky ME, Whitely RJ, August AM, Stagno S, Alford CA Jr (1981) Specific lymphocyte blastogenic responses in children with cytomegalovirus and herpes simplex virus infections acquired early in infancy. Infect Immun 34: 166–170

    PubMed  CAS  Google Scholar 

  160. Pass RF, Stagno S, Britt WJ, Alford CA (1983) Specific cell mediated immunity and the natural history of congenital infection with cytomegalovirus. J Infect Dis 148: 953–961

    PubMed  CAS  Google Scholar 

  161. Peterson PK, Balfour HH Jr, Marker SC, Fryd DS, Howard RJ, Simmons RL (1980) Cytomegalovirus disease in renal allograft recipients: a prospective study of the clinical features, risk factors and impact on renal transplantation. Medicine (Baltimore) 59: 283–300

    CAS  Google Scholar 

  162. Peveri P, Walz A, Dewald B, Baggiolini M (1988) A novel neutrophil-activating factor produced by human mononuclear phagocytes. J Exp Med 167: 1547–1559

    PubMed  CAS  Google Scholar 

  163. Pines J, Hunter T (1990) p34cdc2: the S and M kinase? New Biologist 2: 289–401

    Google Scholar 

  164. Pisano G (1910) Su di un reperto istologico raro in feto scleromatoso. Gazz Osp Clin 31: 249–250

    Google Scholar 

  165. Rando RF, Srinivasan A, Feingold J, Gonczol E, Plotkin S (1990) Characterization of multiple molecular interactions between human cytomegalovirus (HCMV) and human immunodeficiency virus type 1 (HIV-1). Virology 176: 87–97

    PubMed  CAS  Google Scholar 

  166. Rapp F, Geder L, Murasko D, Laush R, Ladda R, Huang ES, Webber MM (1975) Long term persistence of cytomegalovirus genome in cultured human cells of prostatic origin. J Virol 16: 982–990

    PubMed  CAS  Google Scholar 

  167. Rasmussen LE (1991) Gene products of cytomegalovirus and their immunologic significance. In: Ho M (ed) Human cytomegalovirus: biology and infection, 2nd edn. Plenum, New York, pp 37–56

    Google Scholar 

  168. Rasmussen L, Resta S, Merigan T (1991) Human cytomegalovirus glycoprotein-receptor interaction. Transplant Proc 23 [Suppl 31: 60–63

    Google Scholar 

  169. Reynolds DW, Stagno S, Hostly TS, Tiller M, Alford CA Jr (1973) Maternal cytomegalovirus excretion and perinatal infection. N Engl J Med 289: 1–5

    PubMed  CAS  Google Scholar 

  170. Ribbert H (1904) Über protozoenartige Zellen in der Niere eines syphilitischen Neugeborenen und in der Parotis von Kindern. Zentralbl Allg Pathol Anat 15: 945–948

    Google Scholar 

  171. Rifkind D (1965) Cytomegalovirus infection after renal transplantation. Arch Intern Med 116: 554–558

    PubMed  CAS  Google Scholar 

  172. Rinaldo CR Jr, Black PH, Hirsch MS (1977) Virus-leukocyte interactions in cytomegalovirus mononucleosis. J Infect Dis 136: 667–678

    PubMed  Google Scholar 

  173. Rinaldo CR Jr, Carney WP, Richter BS, Black PH, Hirsch MS (1980) Mechanism of immunosuppression in cytomegaloviral mononucleosis. J Infect Dis 141: 488–495

    PubMed  Google Scholar 

  174. Rinaldo CR Jr, Hamoudi WH, DiBaiasio RL, Rabin B, Hakala TR, Liebert M (1983) Cellular immune response and cytomegalovirus infection in renal transplant patients receiving cyclosporine. Transplant Proc 15: 2775–2778

    Google Scholar 

  175. Riviere Y, Blank V, Kourilsky P, Israel A (1991) Processing of the precursor of NF-xB by the HIV-1 protease during acute infection. Nature 350: 625–626

    PubMed  CAS  Google Scholar 

  176. Robinson WE, Montefiori DC, Gillespie DH, Mitchell WM (1989) Complement-mediated, antibody-dependent enhancement of HIV-1 infection in vitro is characterized by increased protein and RNA synthesis and infectious virus release. AIDS 2: 33–42

    CAS  Google Scholar 

  177. Roche JK, Cheng KS, Huang ES, Lang DL (1981) Cytomegalovirus: detection in human colonic and circulating mononuclear cells in association with gastrointestinal disease. Int J Cancer 27: 659–667

    PubMed  CAS  Google Scholar 

  178. Rook AH (1988) Interactions of cytomegalovirus with the human immune system. Rev Infect Dis 10: 5460–467

    Google Scholar 

  179. Rosenberg ZF, Fauci AS (1990) Immunopathogenic mechanism of HIV infection: cytokine induction of HIV expression. Immunol Today 11: 176–189

    PubMed  CAS  Google Scholar 

  180. Rowe WP, Hartley JW, Waterman S, Turner HC, Huebner RJ (1956) Cytopathogenic agent resembling human salivary gland virus recovered from tissue cultures of human adenoids. Proc Soc Exp Biol Med 92: 418–424

    PubMed  CAS  Google Scholar 

  181. Rubin RH, Tolkoff-Rubin NE, Oliver D, Rota TR, Hamilton J, Betts RF, Pass RF, Hillis W, Szmuness W, Farrell ML, Hirsch MS (1985) Multicenter seroepidemiologic study of the impact of cytomegalovirus infection and renal transplantation. Transplantation 40: 243–249

    PubMed  CAS  Google Scholar 

  182. Safai B, Good R (1981) Kaposi’s sarcoma: a review and recent developments. CA 31: 2–12

    PubMed  CAS  Google Scholar 

  183. Safai B, Diaz B, Schwartz J (1992) Malignant neoplasmas associated with human immunodeficiency virus infection. CA 42: 74–95

    PubMed  CAS  Google Scholar 

  184. Sanford EJ, Dagen JE, Geder L, Rohner JT, Rapp F (1977) Lymphocyte reactivity against virally transformed cells in patients with urologic cancer. J Urol 118: 809–810

    PubMed  CAS  Google Scholar 

  185. Sambucetti LC, Cherrington JM, Wilkinson GWG, Mocarski ES (1989) NF-xB activation of the cytomegalovirus enhancer is mediated by a viral transactivator and by T cell stimulation. EMBO J 8: 4251–4258

    PubMed  CAS  Google Scholar 

  186. Sawyer MH, Edwards DK, Spector SA (1987) Cytomegalovirus infection and bronchopulmonary dysplasia in premature infants. Am J Dis Child 141: 303–305

    PubMed  CAS  Google Scholar 

  187. Schmitz H, Enders G (1977) Cytomegalovirus as a frequent cause of Guillian-Barré syndrome. J Med Virol 1: 21–27

    PubMed  CAS  Google Scholar 

  188. Sen R, Baltimore D (1986) Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 46: 705–716

    PubMed  CAS  Google Scholar 

  189. Shelbourn SL, Kothari SK, Sissons JG, Sinclair JH (1989) Repression of human cytomegalovirus gene expression associated with a novel immediate early regulatory region binding factor. Nucleic Acids Res 17: 9165–9171

    PubMed  CAS  Google Scholar 

  190. Shirakawa F, Mizel SB (1989) In vitro activation and nuclear translocation of NF-xB catalyzed by cyclic AMP-dependent protein kinase and protein kinase C. Mol Cell Biol 9: 2424–2430

    PubMed  CAS  Google Scholar 

  191. Shirodka S, Ewen M, DeCaprio JA, Morgan J, Livingston DM, Chittenden T (1992) The transcription factor E2F interacts with the retinoblastoma gene product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell 68: 157–166

    Google Scholar 

  192. Singh N, Dummer JD, Kusne S, Breinig MK, Armstrong JA, Makowka L, Starzl TE, Ho M (1988) Infections with cytomegalovirus and other herpesviruses in 121 liver transplant recipients: transmission by donated organ and the effect of OKT3 antibodies. J Infect Dis 158: 124–131

    PubMed  CAS  Google Scholar 

  193. Skolnik PR, Kosloof BR, Hirsch MS (1988) Bidirectional interactions between human immunodeficiency virus type 1 and cytomegalovirus. J Infect Dis 157: 508–514

    PubMed  CAS  Google Scholar 

  194. Smith MG (1954) Propagation of salivary gland virus of mouse in tissue cultures. Proc Soc Exp Biol Med 86: 435–440

    PubMed  CAS  Google Scholar 

  195. Smith MG (1956) Propagation in tissue cultures of a cytopathogenic virus from human salivary gland virus (SGV) disease. Proc Soc Exp Biol Med 92: 424–430

    PubMed  CAS  Google Scholar 

  196. Spector DH, Klucher KM, Rabert DK, Wright DA (1990) Human cytomegalovirus early gene expression. Curr Top Microbiol Immunol 154: 21–45

    PubMed  CAS  Google Scholar 

  197. Spector DH, Shaw SB, Hock LT (1984) Association of human cytomegalovirus with Kaposi’s sarcoma. In: Gottlieb MS, Groopman JE (eds) Acquired immune deficiency syndrome. Liss, New York, pp 109–126

    Google Scholar 

  198. Sprecher E, Becker Y (1988) Role of Langerhans cells and Thy. 1 + effector cells in herpes simplex-1 infection in the skin of newborn mice. Arch Virol 100: 285–292

    PubMed  CAS  Google Scholar 

  199. Sprecher E, Becker Y (1988) Role of epidermal Langerhans cell in viral infections. Arch Virol 103: 1–14

    PubMed  CAS  Google Scholar 

  200. Sprecher E, Becker Y (1989) Langerhans cell density and activity in mouse skin and lymph nodes affect herpes simplex type 1 (HSV-1) pathogenicity. Arch Virol 1989: 191–205

    Google Scholar 

  201. Stagno S, Pass RF, Cloud G, Britt WJ, Henderson RE, Waltson PD, Veren DA, Page F, Alford CA (1986) Primary cytomegalovirus infection in pregnancy. Incidence, transmission to fetus and clinical outcome. JAMA 256: 1904–1908

    PubMed  CAS  Google Scholar 

  202. Stagno S, Reynolds DW, Huang ES, Thames SD, Smith RJ, Alford CA Jr (1977) Congenital cytomegalovirus: occurrence in an immune population. N Engl J Med 296: 1254–1258

    PubMed  CAS  Google Scholar 

  203. Stagno S, Reynolds DW, Lakeman A, Charamella LJ, Alford CA (1973) Congenital cytomegalovirus infection: consecutive occurrence due to viruses with similar antigenic compositions. Pediatrics 52: 788–794

    PubMed  CAS  Google Scholar 

  204. Starr JG, Bart RD, Gold E (1970) Inapparent congenital cytomegalovirus infection. Clinical and epidemiologic characteristics in early infancy. N Engl J Med 282: 1075–1078

    PubMed  CAS  Google Scholar 

  205. Starr SE, Tolpin MD, Friedman HM, Paucker K, Plotkin SA (1979) Impaired cellular immunity to cytomegalovirus in congenitally infected children and their mothers. J Infect Dis 140: 500–505

    PubMed  CAS  Google Scholar 

  206. Stern H, Elek SD, Booth JC, Fleck DG (1969) Microbial causes of mental retardation: the role of prenatal infections with cytomegalovirus, rubella virus, and toxoplasma. Lancet 2: 443–448

    PubMed  CAS  Google Scholar 

  207. Stern H, Tucker SM (1973) Prospective study of cytomegalovirus infection in pregnancy. Br Med J 2: 268–270

    PubMed  CAS  Google Scholar 

  208. Stingl G, Rappersberger K, Tschachler E, Gartner S, Groh V, Mann DL, Wolff K, Popovic M (1990) Langerhans cells in HIV-1 infection. J Am Acad Dermatol 22: 1210–1217

    PubMed  CAS  Google Scholar 

  209. Stinski MF (1990) Cytomegalovirus and its replication. In: Fields BN, Knipe DM et al. (eds) Virology, 2nd edn. Raven, New York, pp 1959–1980

    Google Scholar 

  210. Staprans SI, Spector DH (1986) 2.2-Kilobase class of early transcripts encoded by cell-related sequences in human cytomegalovirus strain AD169. J Virol 57: 591–602

    Google Scholar 

  211. Takeda A, Tuazon CU, Ennis FA (1988) Antibody-enhanced infection of HIV via Fc receptor-mediated entry. Science 244: 580–583

    Google Scholar 

  212. Tanaka S, Ihara S, Watanabe Y (1978) Human cytomegalovirus induces DNA-dependent RNA polymerases in human diploid cells. Virology 89: 179–185

    PubMed  CAS  Google Scholar 

  213. Taylor HP, Cooper NR (1989) Human cytomegalovirus binding to fibroblasts is receptor mediated. J Virol 63: 3991–3998

    PubMed  CAS  Google Scholar 

  214. Visser OH, Bos PJ (1986) Kaposi’s sarcoma of the conjunctiva and CMV-retinitis in AIDS. Doc Ophthalmol 64: 77–85

    PubMed  CAS  Google Scholar 

  215. Vinters HV, Kwok MK, Ho HW, Anders KH, Tomiyasu U, Wolfson WL, Robert F (1989) Cytomegalovirus in the nervous system of patients with the acquired immune deficiency syndrome. Brain 112: 245–268

    PubMed  Google Scholar 

  216. a. Wade M, Kowalik TF, Mudryj M, Huang E-S, Azizkhan JC (1992) E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection. Mol Cell Biol 12: 4364–4374

    Google Scholar 

  217. Ward KP, Galloway WH, Auchterlonie IA (1979) A congenital cytomegalovirus infection and diabetes. Lancet 1: 497

    PubMed  CAS  Google Scholar 

  218. Webster A, Lee CA, Cook DG, Grundy JE, Emery VC, Kernoff PB, Griffiths PD (1989) Cytomegalovirus infection and progression towards AIDS in haemophiliacs with human immunodeficiency virus infection. Lancet 2: 63–66

    PubMed  CAS  Google Scholar 

  219. Weller TH (1971) The cytomegalovirus: ubiquitous agents with protean clinical manifestations. N Engl J Med 285:203–214, 267–274

    Google Scholar 

  220. Weller TH, Macauley JC, Craig JM, Wirth P (1957) Isolation of intranuclear inclusion producing agent from infants with illnesses resembling cytomegalic inclusion disease. Proc Soc Exp Biol Med 94: 4–12

    PubMed  Google Scholar 

  221. Whitely RJ, Brasfield DM, Reynolds DW, Stagno S, Tiller RE, Alford CA Jr (1976) Protracted pneumonitis in young infants associated with perinatally acquired cytomegalovirus infection. J Pediatr 89: 16–22

    Google Scholar 

  222. Wildy P (1973) Herpes: history and classification. In: Kaplan AS (ed) The herpesvirus. Academic, New York, pp 1–22

    Google Scholar 

  223. Wiley CA, Schrier RD, Denaro FJ, Nelson JA, Lampert PW, Oldstone MB (1986) Localization of cytomegalovirus proteins and genome during fulminant central nervous system infection in an AIDS patient. J Neuropathol Exp Neurol 45: 127–139

    PubMed  CAS  Google Scholar 

  224. Williams LL, Blakeslee Lee JR, Boldogh I, Haung ES (1980) Detection of cytomegalovirus genomes in human skin fibroblasts by DNA hybridization. J Gen Virol 51: 435–438

    PubMed  CAS  Google Scholar 

  225. Williams LL, Blakeslee Lee JR, Huang ES (1980) Isolation of a new strain of cytomegalovirus from explanted normal skin. J Gen Virol 47: 529–523

    Google Scholar 

  226. Wingard JR, Chen DTH, Burns WH, Fuller DJ, Braine HG, Yeager AM, Kaiser H, Burke PJ, Graham ML, Santos GW (1988) Cytomegalovirus infection after autologous bone marrow transplantation with comparison to infection after allogenic bone marrow transplantation. Blood 71: 1432–1437

    PubMed  CAS  Google Scholar 

  227. Wingard JR, Mellits ED, Sostrin MB, Chen DY, Burns WH, Santos GW, Vriesendrop HM, Beschorner WE, Saral R (1988) Interstitial pneumonitis after allogeneic bone marrow transplantation. Medicine 67: 175–186

    PubMed  CAS  Google Scholar 

  228. Wright DA, Staprans SI, Spectro DH (1988) Four phosphoproteins with common amino termini are encoded by human cytomegalovirus AD169. J Virol 62: 331–340

    PubMed  CAS  Google Scholar 

  229. Wright HT Jr (1973) Cytomegalovirus. In: Kaplan AS (ed) The herpesviruses. Academic, New York, pp 353–388

    Google Scholar 

  230. Wyatt JP, Saxton J, Lee RS, Pinkerton H (1950) Generalized cytomegalic inclusion disease. J Pediatr 36: 271–294

    PubMed  CAS  Google Scholar 

  231. Yamanishi K, Rapp F (1979) Production of plasminogen activator by human and hamster cells infected with human cytomegalovirus. J Virol 31: 415–419

    PubMed  CAS  Google Scholar 

  232. Yeager AS, Grumet FC, Hafleigh EB, Arvin AM, Bradley JE, Prober CG (1981) Prevention of transfusion-acquired cytomegalovirus infections in newborn infants. J Pediatr 98: 281–287

    PubMed  CAS  Google Scholar 

  233. Yoshimura T, Matsushima K, Tanaka S, Robinson EA, Appella E, Oppenheim JJ, Leonard EJ (1987) Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proc Natl Acad Sci USA 84: 9233–9237

    PubMed  CAS  Google Scholar 

  234. Zuelzer WW, Stulberg CS, Page RH, Teruya J, Brough AJ (1966) Etiology and pathogenesis of acquired hemolytic anemia. Transfusion 6: 438–460

    PubMed  CAS  Google Scholar 

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  1. Lineberger Comprehensive Cancer Center, Departments of Medicine, Microbiology and Immunology and Curriculum of Genetics, School of Medicine, University of North Carolina at Chapel Hill, CB# 7295, Rm. 117, Lineberger Building, Chapel Hill, NC, 27599-7295, USA

    Eng-Shang Huang & Timothy F. Kowalik

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  1. Department of Molecular Virology, Faculty of Medicine, Hebrew University of Jerusalem, POB 1172, 910010, Jerusalem, Israel

    Yechiel Becker

  2. Institut für Medizinische Virologie, Universität Heidelberg, Im Neuenheimer Feld 324, W-6900, Heidelberg, Germany

    Gholamreza Darai

  3. Lineberger Comprehensive Cancer Research Center, The University of North Carolina, CB # 7259, Rm. 117, Lineberger Building, 27599-7295, Chapel Hill, NC, USA

    Eng-Shang Huang Ph. D.

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Huang, ES., Kowalik, T.F. (1993). The Pathogenicity of Human Cytomegalovirus: An Overview. In: Becker, Y., Darai, G., Huang, ES. (eds) Molecular Aspects of Human Cytomegalovirus Diseases. Frontiers of Virology, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84850-6_1

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