Delivery of Nerve Growth Factor Within the Rat Brain Using Genetically Modified Cells
enetic modification of primary skin fibroblasts followed by grafting is a new approach to deliver nerve growth factor within the adult central nervous system. Intracerebral grafts of nerve growth factor-producing fibroblasts have been used to assess the regenerative capacities of select neuronal populations within the damaged adult rat brain. Our data reveal that this trophic factor is a necessary requirement to sustain neurons following axotomy. As importantly, nerve growth factor is needed to induce and promote the regeneration of lesioned axons. Regardless of the cellular or extracellular substrates used by these regrowing axons, the availability of nerve growth factor is a minimum requirement for successful regeneration of adult perturbed axons.
KeywordsNerve Growth Factor Cholinergic Neuron Basal Forebrain Medial Septum Nerve Growth Factor Receptor
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