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TNFα and Soluble TNF Receptors in Meningococcemia

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Mediators of Sepsis

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 16))

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Abstract

In septic shock, most of the damage does not come from the invading pathogen but from the host reaction to it. A large variety of humoral mediators were implicated in endotoxemia associated pathology. Two main lines of evidence indicate that TNFα is a key mediator. First, the injection of recombinant human TNFα can by itself induce pathological changes of shock [1–6]. Second, the administration of neutralizing anti-TNF antibodies prevents these changes [7–10].

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Authors
  1. E. Girardin
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Editors and Affiliations

  1. Department of Anesthesiology, Centre Hospitalier, Universitaire de Liège, B-35 Domaine Universitaire du Sart Tilman, 4000, Liège, Belgium

    Maurice Lamy

  2. Department of Intensive Care, Free University Hospital, De Boelelaan 1117, 1007, MS, Amsterdam, The Netherlands

    Lambert G. Thijs

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© 1992 Springer-Verlag Berlin Heidelberg

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Girardin, E. (1992). TNFα and Soluble TNF Receptors in Meningococcemia. In: Lamy, M., Thijs, L.G. (eds) Mediators of Sepsis. Update in Intensive Care and Emergency Medicine, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84827-8_5

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  • DOI: https://doi.org/10.1007/978-3-642-84827-8_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84829-2

  • Online ISBN: 978-3-642-84827-8

  • eBook Packages: Springer Book Archive

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