Mediators of Lung Injury Following Ischemia and Reperfusion

  • J. Hill
  • T. F. Lindsay
  • H. B. Hechtman
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 16)


Multisystem organ failure (MOF) continues to complicate the clinical course of many patients with trauma and sepsis. It has been long appreciated that the lung is a particularly sensitive target organ following remote trauma. In 1938, VH Moon [1] described pulmonary congestion and edema in “wet autopsies” of soldiers who had died of septic shock following traumatic injuries. Lung injury and edema are now well recognized complications following ischemia and reperfusion of tissues remote from the lung, including the lower torso during abdominal aortic aneurysm repair and reperfu-sion of the ischemic intestine or liver [2–4]. In addition, lung injury may result from lung trauma itself following such insults as pulmonary artery occlusion, acid aspiration, pneumothorax, atelectasis and contusion [5, 6].


Lung Injury Adult Respiratory Distress Syndrome Intestinal Ischemia Hindlimb Ischemia Leukocyte Adhesion Deficiency 
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© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • J. Hill
  • T. F. Lindsay
  • H. B. Hechtman

There are no affiliations available

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