Mediators of Lung Injury Following Ischemia and Reperfusion

  • J. Hill
  • T. F. Lindsay
  • H. B. Hechtman
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 16)

Abstract

Multisystem organ failure (MOF) continues to complicate the clinical course of many patients with trauma and sepsis. It has been long appreciated that the lung is a particularly sensitive target organ following remote trauma. In 1938, VH Moon [1] described pulmonary congestion and edema in “wet autopsies” of soldiers who had died of septic shock following traumatic injuries. Lung injury and edema are now well recognized complications following ischemia and reperfusion of tissues remote from the lung, including the lower torso during abdominal aortic aneurysm repair and reperfu-sion of the ischemic intestine or liver [2–4]. In addition, lung injury may result from lung trauma itself following such insults as pulmonary artery occlusion, acid aspiration, pneumothorax, atelectasis and contusion [5, 6].

Keywords

Dust Interferon Histamine Glucocorticoid Pseudomonas 

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References

  1. 1.
    Moon VH (1938) Inflammation. In: Shock and related capillary phenomena (Chapt V), Oxford University Press, New York, pp 64–81Google Scholar
  2. 2.
    Paterson IS, Klausner JM, Goldman G, et al. (1989) Pulmonary edema after aneurysm surgery is modified by mannitol. Ann Surg 210:796–801PubMedGoogle Scholar
  3. 3.
    Caty MG, Guice KS, Oldham KT, Remick DG, Kunkel SI (1990) Evidence for tumor necrosis factor-induced pulmonary microvascular injury after intestinal ischemia reperfusion injury. Ann Surg 212:694–700PubMedCrossRefGoogle Scholar
  4. 4.
    Colletti LM, Remick DG, Burtch GD, Kunkel SL, Streiter RM, Campbell DA (1990) Role of tumour necrosis factor alpha in the pathophysiologic alterations after hepatic ischemia/reper-fusion injury in the rat. J Clin Invest 85:1936–1943PubMedCrossRefGoogle Scholar
  5. 5.
    Horgan MJ, Wright SD, Malik AB (1990) Antibody against leukocyte integrin (CD 18) prevents reperfusion-induced lung vascular injury. Am J Physiol 259:315–319Google Scholar
  6. 6.
    Goldman G, Welbourn R, Lindsay T, Hill J, Shepro D, Hechtman HB (1991) Neutrophil adhesion receptors mediate remote aspiration injury. FASEB J A:6503Google Scholar
  7. 7.
    Moore FD (1959) In: Metabolic care of the surgical patient, WB Saunders Co, Philadelphia, PA, pp 97.Google Scholar
  8. 8.
    Klass AA (1953) Acute mesenteric arterial occlusion: Restoration of blood flow by embolec-tomy. J Int Coll Surg 20:687–694PubMedGoogle Scholar
  9. 9.
    Klausner JM, Paterson IS, Goldman G, Valeri CR, Shepro D, Hechtman HB (1989) Throm-boxane A2 mediates increased pulmonary microvascular permeability following limb ischemia. Circ Res 64:1178–1189.PubMedGoogle Scholar
  10. 10.
    Hocking DC, Phillips PG, Ferro TJ, Johnson A (1990) Mechanisms of pulmonary edema induced by tumor necrosis factor-α. Circ Res 67:68–76PubMedGoogle Scholar
  11. 11.
    Klausner JM, Paterson IS, Valeri CR, Shepro D, Hechtman HB (1988) Limb ischemia-induced increase in permeability is mediated by leukocytes and leukotrienes. Ann Surg 208:755–760PubMedCrossRefGoogle Scholar
  12. 12.
    Wakabayashi G, Gelfand JA, Burke JF, Thompson RC, Dinarello CA (1991) A specific receptor antagonist for interleukin 1 prevents Escherichia coli-induced shock in rabbits. FASEB J 5:338–343PubMedGoogle Scholar
  13. 13.
    Michie HR, Manogue KR, Spriggs DR, et al.(1988) Detection of circulating tumor necrosis factor after endotoxin administration. N Eng J Med 318:1481–1486CrossRefGoogle Scholar
  14. 14.
    Dubravec DB, Spriggs DR, Mannick JA, Rodrick ML (1990) Circulating human peripheral blood granulocytes synthesize and secrete tumor necrosis factor a. Proc Natl Acad Sci USA 87:6758–6761PubMedCrossRefGoogle Scholar
  15. 15.
    Dinarello CA (1991) Interleukin-1 and Interleukin-1 antagonism. Blood 77:1627–1652PubMedGoogle Scholar
  16. 16.
    Kurt-Jones EA, Beller DI, Mizel SB (1985) Identification of a membrane-αssociated interleukin-1 in macrophages. Proc Natl Acad Sci USA 82:1204–1208PubMedCrossRefGoogle Scholar
  17. 17.
    Nathan C, Srimal S, Farber C, et al(1989) Cytokine-induced respiratory burst of human neu-trophils: Dependence on extracellular matrix proteins and CD18/CD18 integrins. J cell Biol 109:1341–1349PubMedCrossRefGoogle Scholar
  18. 18.
    Gamble JR, Harlan JM, Klebanoff SJ, Vadas MA (1985) Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor. Proc Natl Acad Sci USA 82:8667–8671PubMedCrossRefGoogle Scholar
  19. 19.
    Smith CW, Kishimoto TK, Abassi O, et al. (1991) Chemotactic factors regulate lectin adhesion molecule 1 (LECAM-1)-dependent neutrophil adhesion to cytokine-stimulated endothe-lial cells in vitro. J Clin Invest 87:609–618PubMedCrossRefGoogle Scholar
  20. 20.
    Movat HZ, Burrowes CE, Cybulsky MI, Dinarello CA (1987) Acute inflammation and a Schwartzman-like reaction induced by interleukin-1 and tumor necrosis factor. Synergistic action of the cytokines in the induction of inflammation and microvascular injury. Am J Pa-thol 129:463–476Google Scholar
  21. 21.
    Abe Y, Sekiya S, Yamashita T, Sendo F (1990) Vascular hyperpermeability induced by tumor necrosis factor and its augmentation by IL-1 and IFN-γ is inhibited by selective depletion of neutrophils with a monoclonal antibody. J Immunol 145:2902–2907PubMedGoogle Scholar
  22. 22.
    Ulich TR, Yin S, del Castillo J, Eisenberg SP, Thompson RC (1991) The intratracheal administration of endotoxin and cytokines. The interleukin-1 receptor antagonist inhibits endoto-xin-and IL-1-induced acute inflammation. Am J Pathol 138:521–524PubMedGoogle Scholar
  23. 23.
    Goldblum SE, Jay M, Yoneda K, Cohen DA, McClain CJ, Gillespie MN (1987) Monokine-induced acute lung injury in rabbits. J Appl Physiol 63:2093–2100PubMedGoogle Scholar
  24. 24.
    Welbourn R, Goldman G, Riordan MO (1991) Role for tumor necrosis is factor as a mediator of lung injury following lower torso ischemia. Am J Physiol 70:2645–2650Google Scholar
  25. 25.
    Okusawa S, Gelfand JA, Ikejima T, Connolly RJ, Dinarello CA (1988) Interleukin-1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cy-clooxygenase inhibition. J Clin Invest 81:1162–1172PubMedCrossRefGoogle Scholar
  26. 26.
    Waage A, Espevik T (1988) Interleukin 1 potentiates the lethal effects of tumor necrosis fac-tor-α/cachectin in mice. J Exp Med 167:1987–1992PubMedCrossRefGoogle Scholar
  27. 27.
    Beutler B, Milsark IW, Cerami AC, et al. (1985) Passive immunization against cachectin/tu-mor necrosis factor protects mice from lethal effect of endotoxin. Science 229:869–871PubMedCrossRefGoogle Scholar
  28. 28.
    Tracey KJ, Fong Y, Hesse DG, et al (1987) Anti-cachetin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 330:662–664PubMedCrossRefGoogle Scholar
  29. 29.
    Ohlsson K, Björk P, Bergenfeldt M, Hageman R, Thompson RC (1990) Interleukin-1 receptor antagonist reduces mortality from endotoxin shock. Nature 348:550–552PubMedCrossRefGoogle Scholar
  30. 30.
    Carter DB, MR Deibel, CJ Dunn, et al. (1990) Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein. Nature 344:633–638PubMedCrossRefGoogle Scholar
  31. 31.
    Mclntyre KW, Stepan GJ, Kolinsky KD, et al. (1991) Inhibition of interleukin-1 binding and bioactivity in vitro, and modulation of acute inflammation in vivo by IL-1 receptor antagonist and anti-IL-1 receptor monoclonal antibody. J Exp Med 173:931–939CrossRefGoogle Scholar
  32. 32.
    Karolle BL, Weiss SJ, Huber AR, Lim MJ, Buda AJ (1991) The recombinant receptor antagonist to interleukin-1 reduces myocardial neutrophil accumulation and tissue injury following ischemia and reperfusion. Circulation 84:A336Google Scholar
  33. 33.
    Stewart AG, Dubbin PN, Harris T, Dusting GJ (1990) Platelet-activating factor may act as a second messenger in the release of ecosanoids and Superoxide anions from leukocytes and endothelial cells. Proc Natl Acad Sci USA 87:3215–3219PubMedCrossRefGoogle Scholar
  34. 34.
    Kuijpers VW, Hakkert BC, Hoogerwerf M, Leeuwenberg JF, Roos D (1991) Role of endothelial leukocyte adhesion molecule-1 and platelet activating factor in neutrophil adherence to IL-1-prestimulated endothelial cells. Endothelial leukocyte adhesion molecule-1 mediated CD18 activation. J Immunol 147:1369–1376PubMedGoogle Scholar
  35. 35.
    Anderson BO, Poggetti RS, Shanley PF, et al. (1991) Primed neutrophils injure rat lung through a platelet-activating factor-dependent mechanism. J Surg Res 50:510–514PubMedCrossRefGoogle Scholar
  36. 36.
    Mozes T, Braquet P, Filep J (1989) Platelet-activating factor: An endogenous mediator of mesenteric ischemia-reperfusion-induced shock. Am J Physiol 257:872–877Google Scholar
  37. 37.
    Marks RM, Todd RF III, Ward PA (1989) Rapid induction of neutrophil-endothelial adhesion by endothelial complement fixation. Nature 339:314–317PubMedCrossRefGoogle Scholar
  38. 38.
    Crawford MH, Grover FL, Kolb WP, et al. (1988) Complement and neutrophil activation in the pathogenesis of ischemic myocardial injury. Circulation 78:1449–1458PubMedCrossRefGoogle Scholar
  39. 39.
    Moore FD Jr, Warner KG, Assousa S, Valeri CR, Khuri SF (1988) The effects of complement activation during cardiopulmonary bypass. Attenuation by hypothermia, heparin and hemodilution. Ann Surg 208:95–103PubMedCrossRefGoogle Scholar
  40. 40.
    Hammerschmidt DE, Weaver LJ, Hudson LD, Craddock PR, Jacob HS (1980) Association of complement activation and elevated plasma C5a with adult respiratory distress syndrome: Pathophysiologic relevance and possible prognostic value. Lancet 1:947–949PubMedCrossRefGoogle Scholar
  41. 41.
    Weinberg P, Matthay M, Webster R, Roskos K, Goldstein I, Murray J (1984) Biologically active products of complement and acute lung injury in patients with the sepsis syndrome. Am Rev Resp Dis 130:791–796PubMedGoogle Scholar
  42. 42.
    Duchateau J, Haas M, Schreyen H, Radoux L, Sprangers I, Noel F (1984) Complement activation in patients at risk of developing the adult respiratory distress syndrome. Am Rev Resp Dis 130:1058–1064PubMedGoogle Scholar
  43. 43.
    Weisman HF, Bartow T, Leppo MK et al. (1991) Soluble human complement receptor type 1: In vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis. Science 249:146–151CrossRefGoogle Scholar
  44. 44.
    Weiss SJ (1989) Tissue destruction by neutrophils. N Engl J Med 320:365–376PubMedCrossRefGoogle Scholar
  45. 45.
    Klausner JM, Paterson IS, Kobzik L, Valeri CR, Shepro D, Hechtman HB (1989) Oxygen free radicals mediate ischemia-induced lung injury. Surgery 104:192–199Google Scholar
  46. 46.
    Petrone WF, English DK, Wong K, McCord JM (1980) Free radicals and inflammation su-peroxide-dependent activation of neutrophil chemotactic factor in plasma. Proc Natl Acad Sci USA 77:1159–1163PubMedCrossRefGoogle Scholar
  47. 47.
    Wems S, Brinker J, Gruber J, et al.(1989) A randomized, double-blind trial of recombinant human Superoxide dismutase (SOD) in patients undergoing PTCA for acute MI. Circulation 80(Suppl):113Google Scholar
  48. 48.
    Schneeberger H, Illner WD, Abendroth D, et al. (1989) First clinical experiences with super-oxide dismutase in kidney transplantation: Results of a double blind randomized study. Transplantation Proceedings 21:1245–1246PubMedGoogle Scholar
  49. 49.
    Harlan JM (1985) Leukocyte-Endothelial interactions. Blood 65:513–525PubMedGoogle Scholar
  50. 50.
    Wedmore CV, Williams TJ (1981) Control of vascular permeability by polymorphnuclear leukocytes in inflammation. Nature 289:646–650PubMedCrossRefGoogle Scholar
  51. 51.
    Welbourn CRB, Goldman G, Paterson IS, Valeri CR, Shepro D, Hechtman HB (1991) Neutrophil elastase and oxygen radicals: Synergism in lung injury after hindlimb ischemia. Am J Physiol 260:1852–1856Google Scholar
  52. 52.
    Jaeschke H, Farhood A, Wayne-Smith C (1990) Neutrophils contribute to ischemia/reperfu-sion injury in rat liver in vivo. FASEB J 4:3355–3359PubMedGoogle Scholar
  53. 53.
    Hernandez LA, Grisham MB, Twohig B, Arfors KE, Harlan JM, Granger DN (1987) Role of neutrophils in ischemia/reperfusion-induced microvascular injury. Am J Physiol 253:699–703Google Scholar
  54. 54.
    Schmeling DJ, Caty MG, Oldham KT, Guice KS, Hinshaw DB (1989) Evidence for a neutrophil related acute lung injury following intestinal ischemia-reperfusion injury. Surgery 106:195–203PubMedGoogle Scholar
  55. 55.
    Lo SK, Van Seventer GA, Levin SM, Wright SD (1989) Two leukocyte receptors (CD11a/CD18 and CD11b/CD18) mediate transient adhesion to endothelium by binding to different ligands. J Immunol 143:3325–3329PubMedGoogle Scholar
  56. 56.
    Smith CW, Marlin SD, Rothlein R, Toman C, Anderson DA (1989) Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro. J Clin Invest 83:2008–2017PubMedCrossRefGoogle Scholar
  57. 57.
    Shappell SB, Toman C, Anderson DC, Taylor AA, Entman ML, Wayne Smith C (1990) Mac-1 (CD11b/CD18) mediates adherence-dependence hydrogen peroxide production by human and canine neutrophils. J Immunol 144:2702–2711PubMedGoogle Scholar
  58. 58.
    Luscinskas FW, Brock AF, Arnaout MA, Gimbrone NM (1989) Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-independent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endotheli,-um. J Immunol 142:2257–2263PubMedGoogle Scholar
  59. 59.
    Schleiffenbaum B, Moser R, Patarroyo M, Fehr J (1989) Me cell surface glycoprotein Mac-1 (CD11b/CD18) mediates neutrophil adhesion and modulates degranulation independently of its cell surface expression. J Immunol 142:3527–3545Google Scholar
  60. 60.
    Lopez AF, Williamson DJ, Gamble JR, et al. (1986) A recombinant human granulocyte-ma-crophage colony-stimulation factor (rhGM-CSF) stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression and survival. J Clin Invest 78:1220–1228PubMedCrossRefGoogle Scholar
  61. 61.
    Welbourn R, Goldman G, Kobzik L, Valeri CR, Shepro D, Hechtman HB (1990) Neutrophil adherence receptors (CD18) in ischemia: Dissociation between quantitative cell surface expression and diapedesis mediated by leukotriene B4. J Immunol 145:1906–1911PubMedGoogle Scholar
  62. 62.
    Lawrence MB, Smith CW, Eskin SG, Mclntire LV (1990) Effect of venous shear stress on CD18-mediated neutrophil adhesion to cultured endothelium. Blood 75:227–237PubMedGoogle Scholar
  63. 63.
    Vedder NB, Winn RK, Rice CL, Chi EY, Arfors KE, Harlan JM (1988) A monoclonal antibody to the adherence-promoting leukocyte glycoprotein, CD18, reduces organ injury and improves survival from haemorrhagic shock and resuscitation in rabbits. J Clin Invest 81:939–944PubMedCrossRefGoogle Scholar
  64. 64.
    Welboum R, Goldman G, Valeri CR, Shepro D, Hechtman HB (1992) Lung injury following hindlimb ischemia is mediated by neutrophil CD18 adherence receptors. Circ Res (In press)Google Scholar
  65. 65.
    Walsh CJ, Carey PD, Cook DJ, Bechard DE, Fowler AA, Sugarman HJ (1991) Anti CD18 antibody attenuates neutropenia and alveolar capillary-membrane injury during gram-negative sepsis. Surgery 110:205–212PubMedGoogle Scholar
  66. 66.
    Doerschuk CM, Winn RK, Coxson HO, Harlan JM (1990) CD 18-dependent and independent mechanisms of neutrophil emigration in the pulmonary and systemic microcirculation of rabbits. J Immunol 144:2327–2333PubMedGoogle Scholar
  67. 67.
    Mileski W, Winn R, Harlan J, Rice C (1989) Inhibition of neutrophil adhesion in sepsis. Surg Forum 40:107–108Google Scholar
  68. 68.
    Pober JS, Gimbrone MA, Lapierre LA, et al. (1986) Overlapping patterns of activation of human endothelial cells by interleukin-1, tumor necrosis factor, and immune interferon. J Immunol 137:1893–1896PubMedGoogle Scholar
  69. 69.
    Smith CW, Rothlein R, Hughes B, Mariscalco M, Schmalsteig F, Anderson DC (1988) Recognition of an endothelial determinant for CD 18-dependent human neutrophil adherence and transendothelial migration. J Clin Invest 82:1746–1756PubMedCrossRefGoogle Scholar
  70. 70.
    Horgan MJ, Ge M, Gu J, Rothlein R, Malik AB (1991) Protective effect of monoclonal antibody RR1 directed against intercellular adhesion molecule ICAM-1 in reperfusion lung injury. Am Rev Resp Dis 143:A578Google Scholar
  71. 71.
    Bevilacqua MP, Pober JS, Wheeler ME, Cotran RS, Gimbrone MA Jr (1985) Interleukin-1 acts on cultured human vascular endothelial cells to increase the adhesion of polymorphonuclear leukocytes, monocytes and related leukocyte cell lines. J Clin Invest 76:2003–2011PubMedCrossRefGoogle Scholar
  72. 72.
    Munro JM, Pober JS, Cotran RS (1989) Tumor necrosis factor and interferon-gamma induce distinct patterns of endothelial activation and associated leukocyte accumulation in skin of Papio anubis. Am J Path 135:121–133PubMedGoogle Scholar
  73. 73.
    Philips ML, Nudelman E, Gaeta FC, et al. (1991) ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-lex. Science 250:1130–1135CrossRefGoogle Scholar
  74. 74.
    Picker LJ, Wamock RA, Bums AR, Doerschuk CM, Berg EL, Butcher EC (1991) The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140. Cell 66:921–933PubMedCrossRefGoogle Scholar
  75. 75.
    Mulligan MS, Varani J, Dame MK, et al. (1991) Role of endothelial-leukocyte adhesion molecule 1 (ELAM-1) in neutrophil-mediated lung injury in rats. J Clin Invest 88:1396–1406PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • J. Hill
  • T. F. Lindsay
  • H. B. Hechtman

There are no affiliations available

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