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Anti-Endotoxin Antibodies: A Critical Appraisal

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Mediators of Sepsis

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 16))

Abstract

More than 20 years ago, the hypothesis has been made that antibodies to the core region of endotoxin (lipopolysaccharide, LPS) might afford protection against a great variety of gram-negative strains serologically distinct in their O antigen specificities [1, 2]. These antibodies were elicited by immunization with rough mutants of gram-negative bacilli, the LPS of which is devoid of O antigen, thus exposing the core region at the surface of the bacterial membrane. It was postulated that these antibodies could recognize an epitope of the core region shared by endotoxins from pathogenic gram-negative bacteria. The initial studies were performed with antisera or immunoglobulin fractions. Recently, investigations were performed with anti-core LPS monoclonal antibodies, in particular antibodies to the lipid A region of LPS. However, the concept has been the subject of considerable debates [3, 4]. Several points remain unclear:

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Authors
  1. J. D. Baumgartner
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Editors and Affiliations

  1. Department of Anesthesiology, Centre Hospitalier, Universitaire de Liège, B-35 Domaine Universitaire du Sart Tilman, 4000, Liège, Belgium

    Maurice Lamy

  2. Department of Intensive Care, Free University Hospital, De Boelelaan 1117, 1007, MS, Amsterdam, The Netherlands

    Lambert G. Thijs

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© 1992 Springer-Verlag Berlin Heidelberg

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Baumgartner, J.D. (1992). Anti-Endotoxin Antibodies: A Critical Appraisal. In: Lamy, M., Thijs, L.G. (eds) Mediators of Sepsis. Update in Intensive Care and Emergency Medicine, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84827-8_22

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  • DOI: https://doi.org/10.1007/978-3-642-84827-8_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84829-2

  • Online ISBN: 978-3-642-84827-8

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