Skip to main content
SpringerLink
Log in

Wachstumsfaktoren und Zytokine in der inneren Medizin

  • Conference paper
Verhandlungen der Deutschen Gesellschaft für Innere Medizin

Part of the book series: Verhandlungen der Deutschen Gesellschaft für Innere Medizin ((VDGINNERE,volume 97))

  • 25 Accesses

Zusammenfassung

Die anerkannteste und am besten untersuchte Hypothese der Pathogenese kardiovaskulärer Erkrankungen ist die „Response to injury hypothesis“ von Ross et al. [5, 11, 15]. Die Hypothese geht davon aus, daß am Beginn der Erkrankung, unter der Einwirkung der „Risikofaktoren“ Hypertonie, Hypercholesterinämie, Diabetes Mellitus und Nikotinabusus, eine Läsion der thromboresistenten Endothelzellen steht. Morphologische Untersuchungen am Tiermodell und am Menschen zeigen, daß die früheste Veränderung der Arterienwand die Adhäsion zirkulierender Lymphozyten und Monozyten an das Endothel ist. Die Zellen überwinden die Endothelzellbarriere und infiltrieren die Intima. Während des Infiltrationsprozesses unterliegen die Monozyten der Differenzierung zu stoffwechselaktiven Gewebsmakrophagen, während die Lymphozyten zu immunkompetenten T-Lymphozyten aktiviert werden (beide Zelltypen werden in enger morphologischer Nachbarschaft gefunden [8, 9]). Erst jetzt kommt es zur Migration glatter Muskelzellen aus der Media, und es setzt anschließend eine ausgeprägte Proliferation der glatten Muskelzellen ein. Die arteriosklerotische „proliferative Läsion“ ist in diesem Stadium durch vier Zelltypen, funktionell geschädigte Endothelzellen, differenzierende Makrophagen, aktivierte T-Lymphozyten und proliferierende glatte Muskelzellen, gekennzeichnet.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Bishop JM (1987) Science 235: 305–311

    Article  PubMed  CAS  Google Scholar 

  2. Cybulsky MI, Gimbrone MA (1991) Science 251: 788–791

    Article  PubMed  CAS  Google Scholar 

  3. Doolittle RF, Hunkapiller MW, Hood LE, Devare SG, Robbins KC, Aaronson SA, Antoniades HN (1983) Science 221: 275–277

    Article  PubMed  CAS  Google Scholar 

  4. Folkman J, Klagsbrun M (1987) Science 235: 442–447

    Article  PubMed  CAS  Google Scholar 

  5. Gronwald RGK, Majewski MW, Ran WL, Ross R (1990) In: Habenicht A (ed) Growth Factors, Differentiation Factors, and Cytokines. Springer, Heidelberg New York Hongkong Tokyo, pp 279–291

    Book  Google Scholar 

  6. Habenicht AJR, Salbach P, Blattner C, JanBen-Timmen U (1990) In: Habenicht A (ed) Growth Factors, Differentiation Factors, and Cytokines. Springer, Heidelberg New York Hongkong Tokyo, pp 31–42

    Book  Google Scholar 

  7. Habenicht AJR, Salbach P, Goerig M, Zeh W, JanBen-Timmen U, Blattner C, King WC, Glomset JA (1990) Nature 345: 634–636

    Article  PubMed  CAS  Google Scholar 

  8. Hansson GK, Jonasson L, Seifert PS, Stemme S (1989) Arteriosclerosis 9: 567–571

    Article  PubMed  CAS  Google Scholar 

  9. Jonasson C, Holm J, Skalli O, Bonders G, Hansson GK (1986) Arteriosclerosis 6: 131–138

    Article  PubMed  CAS  Google Scholar 

  10. Munro JM, Cotran RS (1988) Lab Invest 58: 249–259

    PubMed  CAS  Google Scholar 

  11. Ross R (1986) N Engl J Med 314: 488–500

    Article  PubMed  CAS  Google Scholar 

  12. Ross R, Masuda J, Raines EW, Gown AM, Katsuda S, Sasahara M, Malden LT, Masuko H, Sato H (1990) Science 248: 1009–1012

    Article  PubMed  CAS  Google Scholar 

  13. Rubin K, Tingstrom A, Hansson GK, Larsson E, Ronnstrand L, Klareskog L, Claesson-Welsh L, Heldin C-H, Fellstrom B, Terracio L (1988) Lancet 1: 1353–1356

    Article  PubMed  CAS  Google Scholar 

  14. Sherr CJ, Rettenmier CW, Sacca R, Roussel MF, Look AT, Stanley ER (1985) Cell 41: 665–676

    Article  PubMed  CAS  Google Scholar 

  15. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL (1989) N Engl J Med 320: 915–923

    Article  PubMed  CAS  Google Scholar 

  16. Waterfield MD, Scrace GT, Whittle N, Stroobant P, Johnsson A, Wasteson A, Westermark B, Heldin C-H, Huang JS, Deuel TF (1983) Nature 304: 35–39

    Article  PubMed  CAS  Google Scholar 

  17. Wilcox JN, Smith KM, Williams LT, Schwartz SM, Gordon D (1988) J Clin Invest 82: 1134–1143

    Article  PubMed  CAS  Google Scholar 

  18. Braun M, Csernok E et al. (1991) Verteilungsmuster der Proteinase 3 bei der Wegenerschen Granulomatose and anderen Vaskulitiden. Imm Infekt 19: 23–24

    CAS  Google Scholar 

  19. Caldas ML, Charles LA et al. (1990) Immunelectron microscopic documentation of the translocation of proteins reactive with ANCA to neurophil cell surface during neutrophil activation. Abs. 3rd Inter. Workshop on ANCA, Washington, Nov. 29–30 1990

    Google Scholar 

  20. Charles LA, Falk RJ et al. (1990) Antibodies against granule proteins, activate neutrophils and monocytes in vitro. Abs. 3rd Int. Workshop on ANCA, Washington, Nov. 29–30, 1990

    Google Scholar 

  21. Chensue SW, Otterness IG et al. (1989) Monokine production by hypersensitivity (Schisostoma mansoni egg.) and foreign body (Sephadex bead)-type granuloma makrophage. 2: 144–159

    Google Scholar 

  22. Churg J, Churg A (1989) Idiopathic and secondary vasculitis: A review. Modern Pathol 2: 144–159

    Google Scholar 

  23. Csernok E, Lüdemann J et al. (1990) Ultrastructural localization of Proteinase 3, the target antigen of anti-cytoplasmatic antibodies circulating in Wegener’s granulomatosis. Americ J Pathol 137: 1113–1120

    CAS  Google Scholar 

  24. Deguchi Y, Shibata N et al. (1990) Enhanced expression of the tumor necrosis factor/cachectin gene in peripheral blood mononuclear cells from patients with systematic vasculitis. Clin exp Immunlol 81: 311–314

    Article  CAS  Google Scholar 

  25. Ewert B, Falk RJ et al. (1990) Anti-neutrophil cytoplastic antibodies stimulate neurophils to injure endothelial monolayers in vitro. Abs. 3rd Int. Workshop on ANCA, Washington, Nov. 29–30, 1990

    Google Scholar 

  26. Falk RJ, Terell R et al. (1990) Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci USA 37: 4115–4119

    Article  Google Scholar 

  27. Fauci AS (1983) Vasculitis. J Allergy Clin Immunol 72,3: 211–226

    Google Scholar 

  28. Fujimoto T, Lockwood (1990) Antineutrophil cytoplasm antibodies (ANCA) activate protein kinase C in human neutrophils and HL-60 cells. Abs. 3rd Int. Workshop on ANCA, Washington, Nov. 29–30, 1990

    Google Scholar 

  29. Gabay JE, Scott RW et al. (1989) Antibiotic proteins of human polymorphonuclear leukocytes. Proc Natl Acad Sci USA 86: 5610–5614

    Article  PubMed  CAS  Google Scholar 

  30. Girardin E, Grau GE et al. (1988) Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura. N Engl J Med 319: 397–400

    Article  PubMed  CAS  Google Scholar 

  31. Grau GE, Roux-Lombard Pet al. (1989) Serum cytokines changes in systemic vasculitis. Immun 68: 196–198

    CAS  Google Scholar 

  32. Gross WL, Sterry W (1989) Systemische Vaskulitiden. Medwelt

    Google Scholar 

  33. Gross WL, Lüdemann J, Csernok E (1990) Autoantibodies ANCA/ACPA in vasculitis: History, Nomenclature, Target Antigens, Clinical Impact, and Pathogenesis. Clin Immunol Newsletter 10: 159–163

    Google Scholar 

  34. Gross WL (1991) Neue Aspekte bei der Wegener’schen Granulomatose. Dtsch Ärzteblatt (1991) 88: 38–46

    Google Scholar 

  35. Jenne DE, Tschopp J et al. (1990) Wegener’s autoantigen decodet. Nature 346: 520

    Article  PubMed  CAS  Google Scholar 

  36. Jennette JCH, Falk RJ (1990) Antineutrophil Cytoplasmic Autoantibodies and Associated Diseases: A Review. Am J Kidney 6: 517–529

    Google Scholar 

  37. Kallenberg CGM, Cohen Tervaert JW et al. (1991) Autoimmunity to lysosomal enzymes: new clues to vasculitis and glomerulonephritis? Immunology Today 12: 61–64

    Article  PubMed  CAS  Google Scholar 

  38. Kahaleh MB, Smith EA et al. (1988) TNF inhibits endothelial cell growth. Clin Immunol Immunopathol 49: 261

    Article  PubMed  CAS  Google Scholar 

  39. Kao RC, Wehner AC et al. (1988) Proteinase 3, a distinct human polymorphonuclear leukocyte proteinase that produce emphysema in hamsters. J Clin Invest 82: 1963–1973

    Article  PubMed  CAS  Google Scholar 

  40. Kekow J, Heesen C et al. (1990) Correlation of soluble interkeukin-2 receptor (sIL-2R) levels with disease activity in Wegener’s granulomatosis. Abs. 3rd Inter. Workshop on ANCA, Washington, Nov. 29–30, 1990

    Google Scholar 

  41. Kindler V, Sappino A et al. (1990) The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection. Cell 56: 731–740

    Article  Google Scholar 

  42. Kobayashi K, Allred C et al. (1985) Role of interleukin-1 in experimental pulmonary granuloma in mice. J Immunol 134: 358–364

    PubMed  CAS  Google Scholar 

  43. Lüdemann J, Utecht B et al. (1990) Anti-neurophil cytoplasm antibodies in Wegener’s granulomatosis recognize an elastinolitic enzyme. J Exp Med 171: 357

    Article  PubMed  Google Scholar 

  44. Lüdemann J, Utecht B et al. (1991) Anti-cytoplamic antibodies in Wegener’s granulomatosis are directed against proteinase 3. In: Hörl WH, Heiland A (eds) Proteasis III. Plenum Press, New York

    Google Scholar 

  45. Nölle B, Specks U et al. (1989) Anticytoplasmatic autoantibodies: their immunodiagnostic value in Wegener’s granulomatosis. Ann Int Med 111: 28–40

    Article  PubMed  Google Scholar 

  46. Murray HW, Stern JJ et al. (1987) Experimental visceral leishmaniasis: production of interleukin 2 and interferon-y. J Immunol 138: 2290–2297

    PubMed  CAS  Google Scholar 

  47. Waage A, Halsten A et al. (1987) Association between tumor necrosis factor in serum and fatal outcome in patients with meningococcal disease. Lancet I: 355–357

    Google Scholar 

  48. Wegener F (1935) Über generalisierte septische Gefäßerkrankungen. Verh Deutsch Path Ges XXIX: 202–210

    Google Scholar 

  49. Aggarwal BB, Eessalu TE, Hass PE (1985) Characterization of receptors for human tumor necrosis factor and their regulation by y-interferon. Nature 318: 665–667

    Article  PubMed  CAS  Google Scholar 

  50. Bachwich PR, Chensue SW, Lorrick JW, Kunkel SL (1986) Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages. Biochem Biophys Res Commun 136: 94–101

    Article  PubMed  CAS  Google Scholar 

  51. Cominelli F, Dinarello CA (1989) Interleukin-1 in the pathogenesis of and protection from inflammatory bowel disease. Biotherapy 1: 369–375

    Article  PubMed  CAS  Google Scholar 

  52. Cominelli F, Nast CC, Clark BD, Schindler R, Lierena R, Eysselein VE, Thompson RC, Dinarello CA (1990) Interleukin I (Il-1) gene expression, synthesis and effect of specific Il-1 receptor blockade in rabbit immune complex colitis. J Clin Invest 86: 972–980

    Article  PubMed  CAS  Google Scholar 

  53. Dinarello CA, Bishai I, Rosenwasser LJ, Coceani F (1984) The influence of lipooxygenase inhibitors in the in vitro production of human leukocytic pyrogen and lymphocyte activating factor (interleukin-1). Int J Immunopharmacol 6: 43–50

    Article  PubMed  CAS  Google Scholar 

  54. Dinarello CA (1989) Interleukin-1 and its related cytokines. In: Sorg C (ed) Macrophage-derived cell regulatory factors. Karger, Basel, p 105–154

    Google Scholar 

  55. Dustin ML, Rothelin R, Bhan AK, Dinarello CA, Springer TA (1986) Induction by interleukin-1 and interferon-gamma, tissue distribution, biochemistry and function of a natural adherence molecule (ICAM-1). J Immunol 137: 245–254

    PubMed  CAS  Google Scholar 

  56. Endres 5, Cannon JG, Ghorbani R, Dempsey RA, Sisson SD, Lonnemann G, van der Meer JW, Wolff SM (1989) In vitro production of Il-Ib, Il-la, tumor necrosis factor and Il-2 in a large cohort of human subjects: distribution, effect of cyclooxygenase-inhibiton and evidence of independent gene regulation. Eur J Immunol 19: 2327–2333

    Article  PubMed  CAS  Google Scholar 

  57. Fiocchi C (1989) Lymphokines and the intestinal immune response: role in inflammatory bowel disease. Immunol Invest 18: 91–102

    Article  PubMed  CAS  Google Scholar 

  58. Gordon JR, Burd PR, Galli S (1990) Mast cells as a source of multifunctional cytokines. Immunol Today 11: 458–464

    Article  PubMed  CAS  Google Scholar 

  59. Hirano T, Akira S, Taga T, Kishimoto T (1990) Biological and clinical aspects of interleukin-6. Immunol Today 11: 443–449

    Article  PubMed  CAS  Google Scholar 

  60. Isaacs KL, Sartor RB, Haskill JS (1990) Monokine profiles in inflammatory bowel disease: Detection of mRNA by polymerase chain reaction amplification. Gastroenterology 98: A455

    Google Scholar 

  61. James SP, Kwan WC, Sneller MC (1990) T cell lymphokine mRNA expression, lymphokine utilisation and regulatory function in the intestinal mucosal immune system. In: MacDonald TT (ed) Advances in Mucosal Immunology. Kluwer, London

    Google Scholar 

  62. Kelso A (1989) Cytokines: structure, function and synthesis. Current opinion in Immunology 2: 215–225

    Article  PubMed  CAS  Google Scholar 

  63. Knudsen PJ, Dinarello CA, Strom TB (1986) Prostaglandins post-transcriptionally inhibit monocyte expression of intracellular cyclic adenosine monophosphate. J Immunol 137: 3189–3194

    PubMed  CAS  Google Scholar 

  64. Knudsen PJ, Dinarello CA, Strom TB (1987) Glucocorticoids inhibit transcriptional and post-transcriptional expression of interleukin 1 in U937 cells. J Immunol 139: 4129–4134

    PubMed  CAS  Google Scholar 

  65. Kusugami K, Kuroiwa A, Haruta J, Ina K, Shinoda M, Morise K, Saito H (1991) Interleukin-6 activities of lamina propria mononuclear cells (LPMNCs) from patients with ulcerative colitis (UC). Gastroenterology: AGA

    Google Scholar 

  66. Kvale D, Lovhaug D, Sollid LM, Brandzaeg P (1988) TNF-alpha up-regulates expression of secretory component, the epithelial receptor of polymeric Ig. J Immunol 140: 3086–3089

    PubMed  CAS  Google Scholar 

  67. Ligumsky M, Simon PL, Karmeli F, Rachmilewitz D (1990) Role of interleukin-1 in inflammatory bowel disease enhanced production during active disease. Gut 31: 686–689

    Article  PubMed  CAS  Google Scholar 

  68. Lohmann-Matthes ML (1989) Interaction of macrophages and cytokines. Current opinion in Immunology 2: 33–38

    Article  PubMed  CAS  Google Scholar 

  69. MacDonald TT, Hutchings P, Choy MY, Murch S, Cooke A (1990) Tumor necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine. Clin Exp Immunol 81: 301–305

    Article  PubMed  CAS  Google Scholar 

  70. Mahida YR, Wu K, Jewell DP (1989) Enhanced production of interleukin-1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis or Crohns disease. Gut 30: 835–838

    Article  PubMed  CAS  Google Scholar 

  71. Mantovani A, Dejana E (1989) Cytokines as communication signals between leukocytes and endothelial cells. Immunol Today 10: 370–374

    Article  PubMed  CAS  Google Scholar 

  72. Moshage HJ, Roelofs MM, van Pelt JF, Hazenberg BPC, van Leeuwen MA, Aarden LA, Limburg PC, Yap SH (1988) The effect of interleukin-1, interleukin-6 and its interrelationship on the synthesis of serum amyloid A and C-reactive protein in primary cultures of adult human hepatocytes. Biochem Biophys Res Commun 155: 112–117

    Article  PubMed  CAS  Google Scholar 

  73. Noguchi M, Sasaki T, Hiwatashi N, Toyota T (1991) Production of tumor necrosis factor-a from colonic mucosa in inflammatory bowel disease. Gastroenterology AGA

    Google Scholar 

  74. Patton JS, Rice GC, Ranges GE, Palladino A (1989) Biology of the Tumor necrosis factor. In: Sorg C (ed) Macrophage-derived cell regulatory factors. Karger, Basel, pp 89–104

    Google Scholar 

  75. Raedler A, Steffen M, Reinecker C, Witthöft Th, Schreiber S, MacDermott RP (1991) Secretion of pro-inflammatory cytokines of the lamina propria in patients with inflammatory bowel disease. Eingereicht.

    Google Scholar 

  76. Reinecker C, Steffen M, Doehn C, Petersen J, Pflüger I, Voss A, Raedler A (1991) Pro-inflammatory cytokines in intestinal mucosa. Immunol Res (Im Druck)

    Google Scholar 

  77. Rola-Pleszczynski M, Lemaire L (1986) Leukotrienes augment interleukin-1 production by human monocytes. J Immunol 135: 3958–3961

    Google Scholar 

  78. Schindler R, Mancilla J, Endres S, Ghorbani R, Clark SC, Dinarello CA (1990) Correlations and interactions in the production of interleukin-6 (Il-6), Il-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: II-6 suppress Il-1 and TNF. Blood 75: 40–47

    PubMed  CAS  Google Scholar 

  79. Steffen M, Reinecker C, Voss A, Doehn C, Petersen J, Pflüger I, Raedler A (1991) Secretion of tumor necrosis factor alpha (TNFalpha) is reduced in intestinal monocytes/macrophages in HIV-infected patients (Eingereicht )

    Google Scholar 

  80. Stevens C, Walz G, Zanker B, Singaram C, Lipman M, Strom TB (1990) Interleukin-6, Interleukin1-Beta (II-1[3) and Tumor necrosis factor (TNF(x). Expression in inflammatory bowel disease ( IBD ). Gastroenterology 98: A475

    Google Scholar 

  81. Wong GHW, Goeddel DV (1989) Tumor necrosis factor. In: Zembala M, Asherson GL (eds) Human monocytes. Academic Press, London, pp 195–215

    Google Scholar 

  82. Pfeilschifter J (1990) Der Knochenstoffwechsel and seine Aktivitätsparameter. Internist 31: 727–736

    PubMed  CAS  Google Scholar 

  83. Dambacher MA (1982) Praktische Osteologie. Thieme, Stuttgart-New York, pp 58–64

    Google Scholar 

  84. Mundy GR, Roodman GD (1987) Osteoclast ontogeny and function. In: Peck WA (ed) Bone and Mineral Research. Elsevier, Amsterdam, Vol 5: 209–279.

    Google Scholar 

  85. Canalis E et al. (1988) Growth Factors and the regulation of bone remodeling. J Clin Invest 81: 277–281

    Article  PubMed  CAS  Google Scholar 

  86. Pfeilschifter J et al. (1990) Role of Growth Factors in Cartilage and Bone Metabolism. In: Sporn MB, Roberts AB (eds) Handbook of Experimental Pharmacology Vol 95/II. Springer, Berlin Heidelberg, pp 371–400

    Google Scholar 

  87. Wozney JM et al. (1988) Novel regulators of bone formation: molecular clones and activities. Science 242: 1528–1533

    Article  PubMed  CAS  Google Scholar 

  88. Rifkin DB, Moscatelli D (1989) Recent developments in the cell biology of basic fibroblast growth factor. J Cell Biol 109: 1–6

    Article  PubMed  CAS  Google Scholar 

  89. Pfeilschifter J et al. (1990) Characterization of the latent transforming growth factor R complex in bone. J Bone Mineral Res 5: 49–58

    Article  CAS  Google Scholar 

  90. Gowen M et al. (1989) Production of tumor necrosis factor by human osteoblasts is modulated by other cytokines, but not by osteotropic hormones. Endocrinology 126: 1250–1255

    Article  Google Scholar 

  91. Yoshida H et al. (1990) The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 345: 442–444

    Article  PubMed  CAS  Google Scholar 

  92. Wiktor-Jedrzejczak Wet al. (1990) Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse. Proc Natl Acad Sci USA 87: 4828–4832

    Article  PubMed  CAS  Google Scholar 

  93. Felix R et al. (1990) Impairment of macrophage colony-stimulating factor production and lack of resident bone marrow macrophages in the osteopetrotic op/op mouse. J Bone Mineral Res 5: 781–789

    Article  CAS  Google Scholar 

  94. Mundy GR (1990) Hypercalcemia of malignancy. In: Avioli LV, Krane SM (eds) Metabolic Bone Disease and Clinically Related Disorders. WB Saunders, Philadelphia, pp 793–804

    Google Scholar 

  95. Suva LJ et al. (1987) A parathyroid hormone-related protein implicated in malignant hypercalcemia: cloning and expression. Science 237: 893–896

    Article  PubMed  CAS  Google Scholar 

  96. Nowak RA et al. (1990) Squamous cell carcinomas often produce more than a single bone resorption-stimulating factor: role of interleukin-1. Endocrinology 127: 3061–3069

    Article  PubMed  CAS  Google Scholar 

  97. Garrett IR et al. (1987) Production of lymphotoxin, a bone-resorbing cytokine, by cultured human myeloma cells. New Engl J Med 317: 526–532

    Article  PubMed  CAS  Google Scholar 

  98. Als OS et al. (1984) Prevalence of decreased bone mass in rheumatoid arthritis: relation to anti-inflammatory treatment. Clin Rheumatol 3: 201–208

    Article  PubMed  CAS  Google Scholar 

  99. Stashenko Pet al. (1989) Effect of immune cytokines on bone. Immunol Invest 18: 239–249

    Article  PubMed  CAS  Google Scholar 

  100. Ernst et al. (1989) Evidence for a direct effect of estrogen on bone cells in vitro. Steroid Biochem 34: 279–284

    Google Scholar 

  101. Pacifici R et al. (1987) Spontaneous release of interleukin1-like activity from human blood monocytes reflects bone formation of idiopathic osteoporosis. Proc Natl Acad Sci USA 84: 4616–4620

    Article  PubMed  CAS  Google Scholar 

  102. Pacifici R et al. (1989) Increased monocyte interleukin-1 activity and decreased vertebral bone density in patients with fasting idiopathic hypercalciuria. J Clin Endocrinol Metab 71: 138–145

    Article  Google Scholar 

  103. Arlot et al. (1984) Impaired osteoblast function in osteoporosis: comparison between calcium balance and dynamic histomorphometry. Br Med J 289: 517–520

    Google Scholar 

  104. Lomri A, Marie PJ (1990) Bone cell responsiveness to transforming growth factor p, parathyroid hormone, and prostaglandin E2 in normal and postmenopausal osteoporotic women. J Bone Mineral Res 5: 1149–1155

    Article  CAS  Google Scholar 

  105. Urist MR (1989) Bone morphogenetic protein, bone regeneration, heterotopic ossification and the bone—bone marrow consortium. In: Peck WA (ed) Bone and Mineral Research 6, Elsevier, Amsterdam, pp 57–113

    Google Scholar 

  106. Stern DM, Nawroth PP (1987) Vessel Wall. Seminars in Thrombosis and Hemostasis. Thieme, Stuttgart

    Google Scholar 

  107. Brenner BM, Troy IJ, Ballermann BJ (1989) Endothelium dependent vascular responses. J Clin Invest 84: 1373–1378

    Article  PubMed  CAS  Google Scholar 

  108. Nawroth PP, Stern DM (1989) Das Endothel als die zentrale Schaltstelle der Gerinnungskaskade. Kardiol 78: 16–24

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Heidelberg, Deutschland

    A. Habenicht

  2. Abteilung Innere Medizin I, Medizinische Klinik und Poliklinik, Universität Heidelberg, Deutschland

    A. J. R. Habenicht, U. Janßen-Timmen, P. B. Salbach, Ch. Blattner, R. Ziegler, P. P. Nawroth, A. Bierhaus, J. Lin, Y. Zhang & R. Ziegler

  3. Abteilung für Klinische Rheumatologie, Medizinischen Universität zu Lübeck und Medizinische Krankenhausabteilung, Rheumaklinik Bad Bramstedt, Deutschland

    W. L. Gross, E. Csernok & J. Kekow

  4. Medizinische Kern- und Poliklinik, Universitätskrankenhaus Eppendorf, Hamburg, Deutschland

    M. Steffen, Th. Witthöft, S. Schreiber, A. Raedler & C. Reinecker

  5. Sektion Onkologie/Immunologie, Kinderklinik der Universität Heidelberg, Deutschland

    L. Schweigerer

  6. Abteilung Nephrologie, Zentrum der Inneren Medizin der Universität Frankfurt, Main, Deutschland

    R. Stahl

Authors
  1. A. Habenicht
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. J. R. Habenicht
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. U. Janßen-Timmen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. B. Salbach
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ch. Blattner
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. R. Ziegler
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. W. L. Gross
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. E. Csernok
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. J. Kekow
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. M. Steffen
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Th. Witthöft
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. S. Schreiber
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. A. Raedler
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. C. Reinecker
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. L. Schweigerer
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. P. P. Nawroth
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. A. Bierhaus
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. J. Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. Y. Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  20. R. Ziegler
    View author publications

    You can also search for this author in PubMed Google Scholar

  21. R. Stahl
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Humboldtstr. 14, W-6200, Wiesbaden, Germany

    Klaus Miehlke

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Habenicht, A. et al. (1991). Wachstumsfaktoren und Zytokine in der inneren Medizin. In: Miehlke, K. (eds) Verhandlungen der Deutschen Gesellschaft für Innere Medizin. Verhandlungen der Deutschen Gesellschaft für Innere Medizin, vol 97. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84710-3_22

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-84710-3_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55080-8

  • Online ISBN: 978-3-642-84710-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation