Zusammenfassung
Die obere gastrointestinale Blutung äußert sich meist in Form der Leitsymptome Hämatemesis und/oder Meläna. Besonders starke Blutungen können auch zum peranalen Abgang roten Blutes (Hämatochezie) führen. Mehr als 80% aller Blutungsquellen sind im oberen Gastrointestinaltrakt lokalisiert. Pro Jahr werden etwa 100 Patienten/100000 Einwohner mit akuter Gastrointestinalblutung notfallmäßig hospitalisiert. Ätiologisch spielt die Einnahme nicht-steroidaler Antiphlogistika zunehmend eine Rolle. Auch Antikoagulanzien können zur Blutung führen. Bei peptischen Ulzera oder Angiodysplasien ist vor allem die Veranlagung des Patienten ursächlich relevant. Die Letalität bei gastrointestinaler Blutung ist mit 8–10% nach wie vor hoch und läßt sich nur durch eine Optimierung der diagnostisch-therapeutischen Entscheidungssequenz reduzieren.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
Literatur
Christiansen J, Ottenjann R, Arx F von (1989) Placebo-controlled trial with the somatostatin analogue SMS 201–995 in peptic ulcer bleeding. Gastroenterology 97: 568–574
Domschke W, Ottenjann R, Baert AL, Ponette E (1982) Gastrointestinale Blutung: Grundlagen and Diagnostik. In: Siewert JR, Blum AL, Farthmann EH, Lankisch PG (eds) Notfalltherapie. Springer, Berlin Heidelberg New York, p. 89–118
Domschke W, Lederer P, Lux G (1983) The value of emergency endoscopy in upper gastrointestinal bleeding: review and analysis of 2014 cases. Endoscopy 15: 126–131
Forrest JAH, Finlayson NDC, Shearman DJC (1974) Endoscopy in gastrointestinal bleeding. Lancet 2: 394–397
Freitas D, Donato A, Monteiro JG (1985) Controlled trial of liquid monopolar electrocoagulation in bleeding ulcer. Amer J Gastroent 80: 853–857
Koval G, Benner KG, Rösch J, Kozak BE (1987) Aggressive angiographic diagnosis in acute lower gastrointestinal hemorrhage. Dig Dis Sci 32: 248–253
Langman MJS (1990) Problems in assessing pharmacologic treatment of acute upper gastrointestinal bleeding. Hepatogastroenterol 37: 29–30
Pointner R, Schwab G, Königsrainer A, Dietze 0 (1988) Endoscopic treatment of Dieulafoy’s disease. Gastroenterology 94: 563–568
Reichelt H (1990) Gastrointestinale Blutung Charakterisierung durch nuklearmedizinische Methodik. Dtsch Ärzteblatt 87: 1353–1354
Rutgeerts P, Vantrappen G, Broeckaert L, Coremans G, Janssens J, Hide M (1989) Comparison of endoscopic polidocanol injection and YAG laser therapy for bleeding peptic ulcers. Lancet 1: 1164–1167
Silverstein FE, Gilbert DA, Tedesco FJ, Buenger NK, Persing J (1981) The national ASGE survey on upper gastrointestinal bleeding. II. Clinical prognostic factors. Gastrointest Endosc 27: 80–93
Soehendra N (1987) Endoscopic therapy of upper gastrointestinal bleeding. Endoscopy 19: 205–206
Stettmeier H, Bauer R, Flierdt E van de, Langhammer HR, Pabst HW (1987) Szintigraphischer Nachweis gastrointestinaler Blutungen. Der Nuklearmediziner 10: 116–126
Swain CP, Storey DW, Bown SG, Heath J, Mills TN, Salmon PR, Northfield TC, Kirkham JS, O’Sullivan JP (1986) Nature of the bleeding vessel in recurrently bleeding gastric ulcers. Gastroenterology 90: 595–608
Bacon BR, Bailey-Newton RS, Connors AF Jr. (1985) Plural effusions after endoscopie variceal sclerotherapy. Gastroenterology 88: 1910–1914
Bagarani M et al. (1937) Effect of somatostatin in controlling bleeding from esophageal varices. Ital J Surg Sci 17: 21–26
Barsoum MS, Bolous FI, El-Rooby AA, Rizk-Allah MA, Ibrahim AS (1982) Tamponade and injection sclerotherapy in the management of bleeding oesophageal varices. Br J Surg 69: 76–78
Bernuau J, Rueff B (1985) Treatment of acute variceal bleeding. Clinics Gastroenterology 14: 185–207
Burroughs AK, McCormick PA, Hughes MD, Sprengers D, D’Heygere F, McIntyre N (1990) Randomized, double-blind, placebo-controlled trial of somatostatin for variceal bleeding. Gastroenterology 99: 13881395
Cello JP, Grendell JH, Crass RA, Weber TE, Trunkey DD (1987) Endoscopie sclerotherapy versus portacaval shunt in patients with severe cirrhosis and acute variceal hemorrhage. N Engl J Med 316: 11–15
Chojkier M, Conn HO (1980) Esophageal tamponade in the treatment of bleeding varices. Dig Dis Sci 25: 267–272
De Franchis et al. (1988) Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. A prospective multicenter study. N Engl J Med 319: 983–989
Eriksson LS, Brundin T, Söderlund C, Wahren J (1987) Haemodynamic effects of a long-acting somatostatin analogue in patients with liver cirrhosis. Scand J Gastroenterol 22: 919–925
Fort E, Sautereau D, Silvain C, Ingrand P, Pillegand B, Beauchant M (1990) A randomized trial of terlipressin plus nitroglycerin vs. balloon tamponade in the control of acute variceal hemorrhage. Hepatology 11: 678–681
Gimson AES, Westaby D, Hegarty J, Watson A, Williams R (1986) A randomized trial of vasopressin and vasopressin plus nitroglycerin in the control of acute variceal hemorrhage. Hepatology 6: 410–413
Graham DY, Smith JL (1981) The course of patients after variceal hemorrhage. Gastroenterology 80: 800–809
Hsia H-C, Lee F-Y, Tsai Y-T, Lee S-D, Lai K-H, Lin W-J, Lin H-C, Lay C-S, Wang S-S, Lo K-J (1990) Comparison of somatostatin and vasopressin in the control of acute esophageal variceal hemorrhage a randomized controlled study. Chinese J Gastroenterol 7: 71–77
Hunt PS, Korman MG, Hansky J, Parkin WG (1982) An 8-year prospective experience with balloon tamponade in emergency control of bleeding esophageal varices. Dig Dis Sci 27: 413–416
Jenkins SA, Baxter JN, Corbett W, Devitt P, Ware J, Shields R (1985) A prospective randomised controlled clinical trial comparing somatostatin and vasopressin in controlling acute variceal haemorrhage. Brit Med J 290: 275–278
Kobe E, Schentke K-U (1987) Endoskopische Sklerotherapie von Ösophagusvarizen Studien zur Technik und zum Krankheitsverlauf. Dtsch Z Verdau-Stoffwechskrankh 47: 151–157
Kravetz D, Bosch J, Terés J, Bruix J, Rimola A, Rods J (1984) Comparison of intravenous somatostatin and vasopressin infusions in treatment of acute variceal hemorrhage. Hepatology 4: 442–446
Larson AW, Cohen H, Zweiban B, Chapman D, Gourdij M, Korula J, Weiner J (1986) Acute Esophageal variceal sclerotherapy. JAMA 255: 497–500
Lebrec D (1987) Drugs for portal hypertension. J Gastroenterology Hepatology 2: 361–374
Madonia S, Traîna M, Montalbano L, Amico GD (1990) Variceal ulceration following sclerotherapy: normal consequence or complication? Gastrointest Endosc 36: 76–77
McKee R (1990) A study of octreotide in oesophageal varices. Digestion 45 (Suppl 1) 60–65
Meier R, Gyr K (1990) Die medikamentöse Therapie der akuten Ösophagusvarizenblutung mit vasoaktiven Substanzen (Somatostatin und Octreotide.) Z Gastroenterol 28 (Suppl 2) 36–40
Miskowiak J, Burcharth F, Jensen LI (1981) Effect of lower oesopageal sphincter on oesophageal varices. Scand J Gastroenterol 16: 957–960
Mitchell KY, Mac Dougall BRD, Silk DB, Williams R (1978) Importance of repeated endoscopy in determining the source of haemorrhage in portal hypertension. Gut 19: A955
Moretó M, Zaballa M, Bernal A, Ibanez S, Ojembarrena E, Rodriguez A (1988) A randomized trial of tamponade or sclerotherapy as immediate treatment for bleeding esophageal varices. Surg Gynecol Obstet 167: 331–334
Pagliaro L, Burroughs AK, Sorensen TIA, Lebrec D, Morabito A, Amico GD, Tine F (1939) Therapeutic controversies and randomized controlled trials: prevention of bleeding and rebleeding in cirrhosis. Gastroenterol Internat 2: 71
Papazian A, Braillon A, Dupas JL, Sevenet F, Capron JP (1986) Portal hypertensive gastric mucosa: an endoscopic study. Gut 27: 1199–1203
Paquet K-J, Feussner H (1985) Endoscopic sclerosis and esophageal balloon tamponade in acute hemorrhage from esophagogastric varices: a prospective controlled randomized trial. Hepatology 5: 580–583
Paquet K-J, Kalk J-F, Koussouris P (1988) Immediate endoscopic sclerosis of bleeding esophageal varices. Surg Endosc 2: 18–23
Prindiville T, Trudeau W (1986) A comparison of immediate versus delayed endoscopie injection sclerosis of bleeding esophageal varices. Gastrointest Endosc 32: 264–268
Prindiville T, Miller M, Trudeau W (1987) Prognostic indicators in acute variceal hemorrhage after treatment by sclerotherapy. Am J Gastroenterol 82: 655–659
Pugliese D, Lee SS, Koshy A, Cerini R, Ozier Y, Lebrec D (1988) Systemic and splanchnic hemodynamic effects of intravenous hypertonic glucose in patients with cirrhosis. Hepatology 8: 643–646
Ramond M-J, Valla D, Mosnier J-F, Degott C, Bernuau J, Rueff B, Benhamou J-P (1989) Successful endoscopic obturation of gastric varices with butyl cyanoacrylate. Hepatology 10: 488–493
Saari A, Kivilaakso E, Inberg M, Pääkkönen M, Lahtinen J, Höckerstedt K, Schröder T (1990) Comparison of somatostatin and vasopressin in bleeding esophageal varices. Am J Gastroenterol 85: 804–807
Sauerbruch T, Holl J, Ruckdeschel G, Förstl J, Weinzierl M (1985) Bacteriaemia associated with endoscopic sclerotherapy of oesophageal varices. Endoscopy 17: 170–172
Sauerbruch T, Kleber G (1987) Die Therapie blutender Ösophagusvarizen. Internist Welt 6: 160–167
Schellong H (1990) Endoskopische Therapie der portal bedingten Varizenblutung. In: Buess G (Hrsg) Endoskopie. Deutscher Ärzte-Verlag, Köln, 131–143
Schuman BM, Beckman JW, Tedesco FJ, Griffin JW, Jr, Assad RT (1987) Complications of endoscopic injection sclerotherapy: a review. Am J Gastroenterol 82: 823–830
Singal A, Sarin SK, Sood GK, Broor SL (1990) Ulcers after intravariceal sclerotherapy: correlation of symptoms and factors affecting healing. J Clin Gastroenterol 12: 250–254
Söderlund C, Magnusson I, Törngren S, Lundell L (1990) Terlipressin (triglycyl-lysine vasopressin) controls acute bleeding oesophageal varices. Scand J Gastroenterol 25: 622–630
Soehendra N, Grimm H, Nam VCh, Bruckner M (1989) 10Jahres-Erfahrung mit der endoskopischen Sklerotherapie von oesophagogastrischen Varicen. Chirurg 60: 594–598
Stump DL, Hardin TC (1990) The use of vasopressin in the treatment of upper gastrointestinal hemorrhage. Drugs 39: 38–53
Sutton FM (1987) Upper gastrointestinal bleeding in patients with esophageal varices. Am J Med 83: 273–275
Teres J, Planas R, Panes J, Salmeron JM, Mas A, Bosch J, Llorente C, Viver J, Feu F, Rodes J (1990) Vasopressin/Nitroglycerin infusion vs. esophageal tamponade in the treatment of acute variceal bleeding: a randomized controlled trial. Hepatology 11: 964–968
Tasi Y-T, Lay C-S, Lai K-H et al. (1986) Controlled trial of vasopressin plus nitroglycerin vs. vasopressin alone in the treatment of bleeding esophageal varices. Hepatology 6: 406–409
Walker S (1990) Vasoconstrictor therapy in bleeding esophageal varices. Hepato-gastroenterol 37: 538–543
Westaby D, Hayes PC, Gimson AES, Polson RJ, Williams R (1989) Controlled clinical trial of injection sclerotherapy for active variceal bleeding. Hepatology 9: 274–277
Eriksson LS (1988) Hepatic encephalopathy and treatment of oesophageal varices. Scand J Gastroenterol 23: 641–649
Ede JR, Williams R (1986) Occurence and management of cerebral oedema in liver failure. In: Liver Failure. Ed: Williams R; Churchill Livingstone, Edinburgh, London, Melbourne, New York, pp 26–46
Conn HO (1988) The hepatic encehalopathies. In: Hepatic Encephalopathy: Management with Lactulose and Related Carbohydrates. Eds: Conn HO, Bircher J.; Medi-Ed Press, East Lansing, USA, 3–14
Stieber AG, Ambrosino G, Van Thiel D, Iwatsuki S, Starzl TE (1988) Orthotopic liver transplantation for fulminant and subacute hepatic failure. Gastroenterology Clinics of North America 17: 157–165
Uribe M (1988) Dietary management of portal-systemic encephalopathy. In: Hepatic Encephalopathy: Management with Lactulose and Related Carbohydrates. Eds: Conn HO, Bircher J.; Medi-Ed Press, East Lansing, USA, 95–112
Orlandi F, Brunelli E, Benedeti A, Macarri G (1988) Clinical trials of lactulose therapy in hepatic encephalopathy. In: Hepatic Encephalopathy: Management with Lactulose and Related Carbohydrates. Eds: Conn HO, Bircher J.; Medi-Ed Press, East Lansing, USA, pp 191–198
Morgan MY, Alonso M, Stanger LC (1989) Lactitol and lactulose for the treatment of subclinical hepatic encephalopathy in cirrhotic patients. A randomised, cross-over study. J Nepatology 8: 208–217
Conn HO (1988) Adverse reactions and side effects of lactulose and related agents. In: Hepatic Encephalopathy: Management with Lactulose and Related Carbohydrates. Eds: Conn HO, Bircher J.; Medi-Ed Press, East Lansing, USA, pp 199–206
Weber F (1988) Combination therapy with lactulose and antibiotics. In: Hepatic Encephalopathy: Management with Lactuose and Related Carbohydrates. Eds: Conn HO, Bircher J.; Medi-Ed Press, East Lansing, USA, pp 207–217
Scevola D, Zambelli A, Concia E, Perversi L, Candiani C (1989) Nonabsorbable disaccharides plus neomycin in hepatic encephalopathy: Do they enhance each other? La Clinica Therapeutica 129: 105–111
Eriksson LS, Conn HO (1989) Branched-chain amino acids in the management of hepatic encephalopathy: An analysis of variants. Hepatology 10: 228–246
Naylor CD, O’Rourke K, Detsky AS, Baker JP (1989) Parenteral nutrition with branched-chain amino acids in hepatic encephalopathy. Gastroenterology 97: 1033–1042
Berlin JA (1989) Meta-analysis of branched-chain amino acids in hepatic encephalopathy. Gastroenterology 97: 1043–1051
Jones EA (1989) The y-aminobutyric acid A (GABA) receptor complex and hepatic encephalopathy. Annals of Internal Medicine 110: 532–546
O’Grady JG, Gimson AES, O’Brien CJ, Pucknell A, Hughes RD, Williams R. (1988) Controlled trials of charcoal hemoperfusion and prognostic factors in fulminant hepatic failure. Gastroenterology 94: 1186–1192
Van de Stadt J, Gelin M, Burgeois N, De Prez C, Adler M, Lambilliotte JP (1990) Liver transplantation for fulminant hepatic failure in adults. Transplantation Proceedings 22: 1505–1508
Blei AT (1991) Cerebral edema and intracranial hypertension in acute liver failure: Distinct aspects of the same problem. Hepatology 13: 25–28
Forbes A, Alexander GJM, O’Grady JG, Keays R, Gullan R, Dawling S, Wiliams R (1989) Thiopental infusion in the treatment of intracranial hypertension complicating fulminant hepatic failure. Hepatology 10: 306–310
Maganto P, Cienfuegos JA, Santamaria L, Eroles G, Andres S, Pardo F, Castillo-Olivares JL, Municio AM (1990) Transplanted frozen-thawed hepatocytes as a therapeutic approach in liver disease. Transplantation Proceedings 22: 2017–2019
Dixit V, Darvasi R, Arthur M, Brezina M, Lewin K, Gitnick G (1990) Restoration of liver function in Gunn rats without immunosuppression using transplanted microencapsulated hepatocytes. Hepatology 12: 1342–1349
Makowka L, Falk RE, Rotstein LE, Falk JA, Nossal N, Langer B, Blendis LM, Phillips MJ (1980) Cellular transplantation in the treatment of experimental hepatic failure. Science 210: 901–903
Tsubouchi H, Hirono S, Gohda E et al. (1989) Clinical significance of human hepatocyte growth factor in blood from patients with fulminant hepatic failure. Hepatology 9: 875–881
Sinclair SB, Greig PD, Blendis LM, Abecassis M, Roberts EA, Phillips MJ, Cameron R, Levy GA (1989) Biochemical and clinical response of fulminant viral hepatitis to administration of prostaglandin E. J Clin Invest 84: 1063–1069
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Classen, M. et al. (1991). Intensivtherapie bei gastroenterologischen Krankheiten. In: Miehlke, K. (eds) Verhandlungen der Deutschen Gesellschaft für Innere Medizin. Verhandlungen der Deutschen Gesellschaft für Innere Medizin, vol 97. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84710-3_15
Download citation
DOI: https://doi.org/10.1007/978-3-642-84710-3_15
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-55080-8
Online ISBN: 978-3-642-84710-3
eBook Packages: Springer Book Archive