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Regulation of Voltage-Activated K+ Channels

  • Arthur M. Brown
Conference paper
Part of the NATO ASI Series book series (volume 60)

Abstract

Regulation of voltage-activated K+ channels, or any ion channel, has as its final common pathway the channel pore. After first treating some of the regulatory mechanisms, I will discuss our present understanding of pore structure. Regulation of the pore is principally performed by the voltage sensor of the channel and the gates that the sensor opens. It is these processes that are usually modulated, frequently by phosphorylation, and the phosphorylation is often initiated by G protein receptors. However, some K+ channels are gated not by changes in membrane potential but by specific ligands, two notable ligands being G proteins and ATP.

Keywords

Potassium Channel Channel Pore Guanine Nucleotide Binding Protein Chimeric Channel Beta Gamma Subunit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Bibliography

  1. Brown AM, Birnbaumer L (1990) Ionic channels and their regulation by G protein subunits. Ann Rev Physiol 52: 197–213CrossRefGoogle Scholar
  2. Codina J, Yatani A, Grenet D, Brown AM, Birnbaumer L (1987) The alpha subunit of the GTP binding protein Gk opens atrial potassium channels. Science 236: 442–445PubMedCrossRefGoogle Scholar
  3. Frech GC, VanDongen AMJ, Schuster G, Brown AM, Joho RH (1989) A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning. Nature 340: 642–645PubMedCrossRefGoogle Scholar
  4. Guy HR, Conti F (1990) AChR structure: a new twist in the story. Trends In Neurosci 13: 201–206.Google Scholar
  5. Hamilton SL, Codina J, Hawkes MJ, Yatani A, Sawada T, Strickland FM, Froehner SC, Spiegel AM, Toro L, Stefani E, Birnbaumer L, Brown AM (1991) Evidence for direct interaction of Gsa with the Cat+ channel of skeletal muscle. J Biol Chem, submittedGoogle Scholar
  6. Hartmann HA, Kirsch GE, Drewe JA, Taglialatela M, Joho RH, Brown AM (1991) Exchange of conduction pathways between two related K+ channels. Science 251: 942–944PubMedCrossRefGoogle Scholar
  7. Kim D, Lewis D.L, Graziadei L, Neer EJ, Bar-Sagi D, Clapham DE (1989) G-protein beta gamma subunits activate the cardiac muscarinic K+ channel via phospholipase A2. Nature 337: 557–560PubMedCrossRefGoogle Scholar
  8. Kirsch GE, Codina J, Birnbaumer L, Brown AM (1990) Coupling of ATP-sensitive K+ channels to Al receptors by G proteins in rat ventricular myocytes. Am J Physiol 259: H820–826PubMedGoogle Scholar
  9. Kurachi Y, Itoh H, Sugimoto T, Shimizu T, Miki I, Ui M (1989) Arachidonic acid metabilites as intracellular modulators of the G protein-gated cardiac K+ channel. Nature 337: 555–557PubMedCrossRefGoogle Scholar
  10. MacKinnon R, Miller C (1989) Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor. Science 245: 1382–1385Google Scholar
  11. MacKinnon R, Yellen G (1990) Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels. Science 250:276–279Google Scholar
  12. Stevens CF (1991) Making submicroscopic hole in one. Nature 349:657–658 Google Scholar
  13. Tempel BL, Papazian DM, Schwarz TL, Jan YN, Jan LY (1987) Sequence of a probable potassium channel component encoded at the Shaker locus of Drosophila. Science 237: 770–775PubMedCrossRefGoogle Scholar
  14. Toro L, Ramos-Franco J, Stefani E (1990) GTP-dependent regulation of myometrial KCa channels incorporated into lipid bilayers. J Gen Physiol 96: 373–394PubMedCrossRefGoogle Scholar
  15. VanDongen T, Codina J, Olate J, Mattera R, Joho R, Birnbaumer L, Brown AM (1988) Newly identified brain potassium channels gated by the guanine nucleotide binding protein Go. Science 242: 1433–1437CrossRefGoogle Scholar
  16. Yatani A, Codina J, Brown AM, Birnbaumer L (1987) Direct activation of mammalian atrial muscarinic potassium channels by GTP regulatory protein Gk. Science 235: 207–211PubMedCrossRefGoogle Scholar
  17. Yellen G, Jurman ME, Abramson T, MacKinnon R (1991) Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel. Science 251: 9399–942CrossRefGoogle Scholar
  18. Yokoyama S, Imoto K, Kawamura T, Higashida H, Iwabe N, Miyata T, Numa S (1989) Potassium channels from NG108–15 neuroblastoma-glioma hybrid cells. FEBS Lett 259: 37–42PubMedCrossRefGoogle Scholar
  19. Yool AJ, Schwarz TL (1991) Alteration of ionic selectivity of a K+ channel by mutation of the H5 region. Nature 349: 700–704PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Arthur M. Brown
    • 1
  1. 1.Department of Molecular Physiology and BiophysicsBaylor College of MedicineHoustonUSA

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