Regulation of Voltage-Activated K+ Channels
Regulation of voltage-activated K+ channels, or any ion channel, has as its final common pathway the channel pore. After first treating some of the regulatory mechanisms, I will discuss our present understanding of pore structure. Regulation of the pore is principally performed by the voltage sensor of the channel and the gates that the sensor opens. It is these processes that are usually modulated, frequently by phosphorylation, and the phosphorylation is often initiated by G protein receptors. However, some K+ channels are gated not by changes in membrane potential but by specific ligands, two notable ligands being G proteins and ATP.
KeywordsPotassium Channel Channel Pore Guanine Nucleotide Binding Protein Chimeric Channel Beta Gamma Subunit
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