Recent advances in the molecular biology of Cryptococcus neoformans
Cryptococcus neoformans is the causative agent of cryptococcosis. Once a rare disease seen only in the terminally ill, it became much more common with the advent of immunosuppressive regimens for the treatment of neoplastic disease and for transplant maintenance. The disease has taken on added importance as one of the most common opportunistic infections seen in patients with AIDS. Anti-cryptococcal therapy is difficult in AIDS patients due to decreased cure rates and increased relapse rates. This increased incidence of cryptococcosis has lead to increased interest in the mechanism of pathogenesis and virulence.
KeywordsCryptococcus Neoformans Telomere Sequence Homologous Integration URA5 Gene Opposite Mating Type
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- Kwon-Chung KJ (1977) Heterothallism vs self-fertile isolates of Filobasidiella neoformans (Cryptococcus neoformans) in The black and white yeasts Pan American Health Org Sci Pub 356 Proceedings of the IV Int Conf on Mycoses Washington, DC pp 204-213.Google Scholar
- Kwon-Chung KJ and Edman JC (1992) Recent advances in the molecular genetics of Cryptococcus neoformans in New Strategies in Fungal Disease. Churchill Livingstone London pp 195-207.Google Scholar