Recent advances in the molecular biology of Cryptococcus neoformans

  • Jeffrey C. Edman
Conference paper
Part of the NATO ASI Series book series (volume 69)


Cryptococcus neoformans is the causative agent of cryptococcosis. Once a rare disease seen only in the terminally ill, it became much more common with the advent of immunosuppressive regimens for the treatment of neoplastic disease and for transplant maintenance. The disease has taken on added importance as one of the most common opportunistic infections seen in patients with AIDS. Anti-cryptococcal therapy is difficult in AIDS patients due to decreased cure rates and increased relapse rates. This increased incidence of cryptococcosis has lead to increased interest in the mechanism of pathogenesis and virulence.


Cryptococcus Neoformans Telomere Sequence Homologous Integration URA5 Gene Opposite Mating Type 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Jeffrey C. Edman
    • 1
  1. 1.Hormone Research Institute & Department of Laboratory MedicineUniversity of CaliforniaSan FranciscoUSA

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