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Imaging of the yeast killer phenomenon

  • Conference paper
Molecular Biology and its Application to Medical Mycology

Part of the book series: NATO ASI Series ((ASIH,volume 69))

Abstract

Idiotypes, or antigens on the inside (Jerne NK, 1982), are peptide determinants expressed for the antigen on the variable domains of specific immunoglobulin receptors in limphocytes as well as for viruses, toxins or hormones in other cells. The potential of antiidiotypic antibodies as vaccines for immunointervention in microbial infections emerged in the concept that the idiotope of anti-antibodies, being the internal image of the antigenic epitope, might induce primarily an antibody-like response. Ideally, antiidiotype-based vaccines might present several attractive advantages on conventional antigens such as unlimited availability, non infectious nature and ontogenic restriction of the host. Anaphylactic reactions, restricted antigenic response repertoire and high titer of long lasting response should be considered, on the contrary, as possible limits. Conventional vaccines based on live etiologic agents, such as attenuated viruses, may induce reversion to a virulent form or, because of their contents of genomic materials, transformation of host cells. Toxic side effects might occur during immunization with whole microorganisms for the prophylaxis of bacterial, fungal and protozoan diseases. Recombinant vaccination by synthetic peptides may suffer of high costs, poor immunogenicity, side effects of expression vectors (Finberg R, 1981) and be uneffective in case of carbohydrate nature of the immunogenic epitope of the antigen. Theoretically, antiidiotypic antibodies should act as non infectious, non toxic, easy to purify, administer and engineer vaccines.

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Authors and Affiliations

  1. Institute of Microbiology, University of Parma, Via Gramsci, 14, 43100, Parma, Italy

    L. Polonelli, S. Conti, M. Gerloni, W. Magliani & J. C. Cailliez

  2. Istituto di Microbiologia, Università Cattolica del Sacro Cuore, Roma, Italy

    G. Morace

Authors
  1. L. Polonelli
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  2. S. Conti
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  3. M. Gerloni
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  4. W. Magliani
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  5. G. Morace
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  6. J. C. Cailliez
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Editors and Affiliations

  1. International Institute of Genetics and Biophysics, Via Marconi 12, 80125, Naples, Italy

    Bruno Maresca

  2. Division of Infectious Diseases St. Louis, Washington University School of Medicine, Missouri, 63110, USA

    George S. Kobayashi

  3. Research Center for Medical Mycology, Teikyo University School of Medicine, 359 Otsuka, Hachioji-shi, Tokyo, 192-03, Japan

    Hideyo Yamaguchi

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© 1993 Springer-Verlag Berlin Heidelberg

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Polonelli, L., Conti, S., Gerloni, M., Magliani, W., Morace, G., Cailliez, J.C. (1993). Imaging of the yeast killer phenomenon. In: Maresca, B., Kobayashi, G.S., Yamaguchi, H. (eds) Molecular Biology and its Application to Medical Mycology. NATO ASI Series, vol 69. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84625-0_16

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  • DOI: https://doi.org/10.1007/978-3-642-84625-0_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84627-4

  • Online ISBN: 978-3-642-84625-0

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