Mapping of a Hot Spot in the Major Recombination Area of the Mouse H-2 Complex

  • M. Snoek
  • P. C. Groot
  • R. D. Campbell
  • T. Spies
  • P. Demant
Conference paper
Part of the NATO ASI Series book series (volume 59)


Analysis of the class III region of the mouse, using human probes, showed that all human class III genes tested thusfar seem to have homologous counterparts in the mouse genome. Furthermore, the relative gene order of these genes appears to be conserved also. The fine mapping of the C4-H-2D segment shows that the recombination in this interval is not random, but that recombination occurs preferentially in the Hsp70-Bat-5 segment, indicating the existence of a “hot spot”. The determination of crossovers at the molecular level will be helpful in the identification of functionally defined genes, since our structural data gives more information of their localisation of genes controlling disease susceptibility.


Major Histocompatibility Complex Cleft Palate Recombination Site Human Major Histocompatibility Complex Crossover Site 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • M. Snoek
    • 1
  • P. C. Groot
    • 1
  • R. D. Campbell
    • 2
  • T. Spies
    • 3
  • P. Demant
    • 1
  1. 1.Department of Molecular GeneticsThe Netherlands Cancer InstituteAmsterdamThe Netherlands
  2. 2.MRC Immunochemistry Unit, Dept. of BiochemistryUniversity of OxfordEngland
  3. 3.Division of Tumor VirologyDana Farber Cancer InstituteBostonUSA

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