Contributions of Interlocus Exchange to the Structural Diversity of the H-2K, D, and L Alleles
The nature of diversity that distinguishes alleles form each other and from sequences of other class I loci was analyzed using 24 H-2K, D and L sequences, providing statistical evidence that alleles of the K and D/L loci are evolving independently throughout most of their coding regions. However, sequences determining the structure of the antigen binding domains of both allelic series appear to be co-evolving. Sequence motifs that distinguish alleles in these series are present at both the K and D/L loci, a pattern of diversity that is reminiscent of the class I mutants that have been described in the mouse.
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