Cancer Therapy pp 109-120 | Cite as

Hemin is Transported in Human Leukemia K562 Cells and Interacts with DNA Sequences

  • Asterios S. Tsiftsoglou
  • Athina I. Tsamadou
  • Stephen H. Robinson
  • Willie Wong
Part of the NATO ASI Series book series (volume 75)


Heme (ferroprotoporphyrin IX), a natural agent, serves as a prosthetic group in various hemoproteins like hemoglobin, myoglobin, cytochromes, catalase and others involved in oxygen transport, cellular respiration, ATP produetion and drug metabolism (Stryer, 1988). Hemin, the oxidised form of heme, has been shown to activate gene expression and promote differentiation in a variety of cell types including mouse 3T3 cells (Chen and London, 1981), neuroblastoma (Ishii et al, 1978), erythroleukemia (MEL, K562) cells (Ross et al, 1976; Rutherford et al, 1979a; Tsiftsoglou and Robinson, 1985; Tsiftsoglou et al, 1991) as well as normal hematopoietic cells like CFU-E, CFU-GM and BFU-E (Monette et al, 1982) by interacting with cellular components at various levels (Sassa et al, 1988).


K562 Cell Globin Gene Local Control Region Erythroleukemia Cell Hemoglobin Synthesis 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1993

Authors and Affiliations

  • Asterios S. Tsiftsoglou
    • 1
  • Athina I. Tsamadou
    • 1
  • Stephen H. Robinson
    • 2
  • Willie Wong
    • 2
  1. 1.Laboratory of Pharmacology, Department of Pharmaceutical SciencesAristotle University of ThessalonikiThessalonikiGreece
  2. 2.Department of MedicineBeth Israel Hospital and Harvard Medical SchoolBostonUSA

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