CNS and Cardiovascular Effects of TNF-α
Recombinant cytokines have high potential for modulating immunity in cancer, viral illness and immunodeficient states. However their large use in clinical trials turned out to be impraticable because of severe systemic side-effects (Chouaib et al., 1992). The cardiovascular system and Central Nervous System (CNS) represent the main targets of Tumor Necrosis Factor (TNF-α) toxicity. Experimental studies have confirmed that systemic or intracerebral injection of recombinant TNF-α has profound cardiovascular and neurological effects in addition to its pyrogenic and metabolic activity. Understanding and elucidating the mechanisms underlying cardiovascular and CNS toxicity should enable the design of molecules to oppose this toxicity without interfering with the immune reactions.
KeywordsNitric Oxide Platelet Activate Factor Drinking Behavior Central Nervous System Toxicity Recombinant Cytokine
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