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Pathogenesis of Monosodium Urate Crystal-Induced Inflammation

  • R. Terkeltaub
Conference paper

Abstract

Acute articular and periarticular inflammation and chronic articular destructive changes are well-recognized consequences of the deposition, in articular and periarticular tissues, of crystals of the monosodium salt of uric acid (MSU). MSU crystals directly or indirectly activate a remarkable number of humoral and cellular inflammatory mediator systems, and this is reflected in the clinical features of a typical acute gouty paroxysm, i. e., acute onset, severe pain, edema and erythema extending beyond the joint margin, neutro-phil influx and activation, and systemic manifestations. In this chapter, our current understanding of the pathogenesis of MSU-crystal-associated inflammation is reviewed.

Keywords

Neutrophil Activation Acute Gout Urate Crystal Monosodium Urate Acute Gouty Arthritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Verlag, Berlin Heidelberg 1991

Authors and Affiliations

  • R. Terkeltaub

There are no affiliations available

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