Human Embryonal Carcinoma and Yolk Sac Carcinoma in Vitro: Cell Lineage Relationships and Possible Paracrine Growth Regulatory Interactions

  • M. F. Pera
  • S. Cooper
  • W. Bennet
  • I. Crawford-Bryce
Conference paper
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 123)

Abstract

In this chapter, we will review some aspects of work in our laboratory on the control of growth and differentiation in human teratocarcinoma stem cells. We begin by describing the three cell types which we have isolated in vitro from human teratomas: embryonal carcinoma, yolk sac carcinoma resembling visceral endoderm (solid yolk sac carcinoma), and yolk sac carcinoma resembling parietal endoderm (endodermal sinus tumour). Next, we discuss the development of a new panel of monoclonal antibodies for the study of cell differentiation lineage in human teratomas. We then describe properties of a spontaneously differentiating multipotent clone of human embryonal carcinoma, and we present evidence of possible paracrine growth interaction between teratocarcinoma stem cells and yolk sac carcinoma cells.

Keywords

Hydrolysis Migration Filtration Albumin Leukemia 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1991

Authors and Affiliations

  • M. F. Pera
    • 1
  • S. Cooper
    • 1
  • W. Bennet
    • 1
  • I. Crawford-Bryce
    • 1
  1. 1.Department of Zoology, Cancer Research CampaignUniversity of OxfordOxfordGreat Britain

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