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Superselective Therapy for Cerebral Gliomas

  • Chapter
Interventional Neuroradiology

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Abstract

The natural history of glioblastomas has been little altered by therapeutic attempts over the past 30 years. Surgical debulking and radiation therapy have had only a moderate effect on these patients (Neuwelt and Dahlborg 1989), with the median survival being in the range of 7.5–9.5 months (Edwards et al. 1980; Shapiro and Ausman 1969). This dismal prognosis for patients with glioblastomas has stimulated the development of many alternative regimens, such as intra-arterial therapy and local high dose irradiation. This chapter will initially discuss the rationale behind the chemotherapy of brain tumors, the nature of the bloodbrain barrier (BBB) and its significance in the treatment of patients with cerebral glioblastomas, and the problem with the BBB; it will conclude with a discussion on the intra-arterial delivery of chemotherapeutic agents.

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Author information

Authors and Affiliations

  1. Department of Radiology, Section of Neuroradiology, New England Medical Center Hospitals, 750 Washington Street, Boston, MA, 0211, USA

    Samuel M. Wolpert M.B., B.Ch.

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  1. Samuel M. Wolpert M.B., B.Ch.
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Editors and Affiliations

  1. Abteilung für Neuroradiologie Departement Medizinische Radiologie, Universitätsspital Zürich, Frauenklinikstrasse 10, 8091, Zürich, Switzerland

    Anton Valavanis M. D. (Professor) (Professor)

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© 1993 Springer-Verlag Berlin Heidelberg

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Wolpert, S.M. (1993). Superselective Therapy for Cerebral Gliomas. In: Valavanis, A. (eds) Interventional Neuroradiology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84434-8_10

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  • DOI: https://doi.org/10.1007/978-3-642-84434-8_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84436-2

  • Online ISBN: 978-3-642-84434-8

  • eBook Packages: Springer Book Archive

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