Abstract
Measurement of urinary enzyme excretion as a test for the integrity of the renal parenchyma has become a valuable procedure in animal experiments, particularly in nephrotoxicity studies. Since the number of drugs with known nephrotoxic side effects increased from 60 in 1980 [3] to about 150 in 1988 [7], the analysis of urinary enzymes is included in many protocols for drug-testing experiments. This non-invasive method permits monitoring of very early stages of renal injury and allows observation of the same animal over longer periods of time.
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References
Adelman RD, Sprangler WL, Beasom F, Ishizaki G, Conzelman GM (1981) Fursemide enhancement of netilimicin nephrotoxicity in dogs. J Antimicrob Chemother 7:431–440.
Alt J (1988) Proteinurie des Versuchstieres. Parey, Berlin Hamburg (Schriftenreihe Versuchstierkunde H. 13).
Berscheid G, Grötsch H, Hropot M, Klaus E (1983) Enzymurie der Ratte unter Gabe von Azneimitteln. J Clin Chem Clin Biochem 21:239–240.
Bräunlich H, Fleck C (1981) Urinary enzyme excretion as an indicator of nephrotoxicity in dependence on age. Exp Path 20:182–187.
Coper H, Schulze G (1986) Altersbedingte Änderungen in der Empfindlichkeit für Arzneimittel. Internist 27:53–59.
Cronin RE (1979) Aminoglycoside nephrotoxicity: pathogenesis and prevention. Clin Nephrol 11:251–256.
Dukes MNG (ed) (1988) Meyler’s side effect of drugs. 11th edn. Elsevier, Amsterdam.
Grötsch H, Hropot M, Klaus E, Malerczyk V, Mattenheimer, H (1985) Enzymuria of the rat: biorhythms and sex differences. J Clin Chem Clin Biochem 23:343–347.
Grötsch H, Hropot M, Klaus E, Wesely J (1990) Influences of seasonal biorhythms on urinary excretion of enzymes and other parameters. J Clin Chem Clin Biochem 28:285–286.
Hardy ML, Hsu RC, Short CR (1985) The nephrotoxic potential of gentamicin in the cat enzymuria and alterations in urine concentrating capability. J Vet Pharm Ther 8:382–392.
Hrushesky WJM, Levi FA, Halberg F, Kennedy BJ (1982) Circadian stage dependence of cis-diamminedichlorplatinium lethal toxicity in rats. Cancer Res 42:945–949.
Jung K, Burchardt U (1987) Harnenzyme im Experiment und in der Klinik. J Clin Chem Clin Biochem 25:823–828.
Levi F, Hrushesky WJM, Blomquist CH, Lakuta DJ, Haus E, Halberg F, Kennedy BJ (1982) Reduction of cis-diammiedichloroplatinium nephrotoxocity in rats by optimal circadian drug timing. Cancer Res 42:950–955.
Levi F, Boughattas NA, Blazsek I (1987) Comparative murine chronotoxicity of anticancer agents and related mechanism. Ann Rev Chronopharmacol 4:283–331.
Mayersbachv H (1977) Seasonal influences on laboratory rats living under highly standardized environmental conditions. J Interdiscipl Cycle Res 8:385.
McMartin DN, Engel SG (1982) Effect of aging on gentamicin nephrotoxicity and pharmacokinetics in rat. Res Commun Chem Pathol Pharmacol 38:193–207.
Pierce RJ, Price RG, Marsden AM, Fowler JSL (1979) Urinary enzyme assays in toxicological studies in the rat and marmoset. Curr Probl Clin Biochem 9:201–214.
Plummer DT, Noorazar S, Obatomi DK, Haslam JD (1986) Assessment of renal injury by urinary enzymes. Uremia Invest 9:97–102.
Schirrow R, Wesslau C, Jung K (1987) Zur Ausscheidungsrhythmik verschiedener Harnenyzme bei Ratten. Nieren-und Hochdruckrankh 16:407.
Schultz SG, Lavelle KJ, Swain R (1982) Nephrotoxicity of radiocontrastmedia in ischemic renal failure in rabbits. Nephron 32:113–117.
Schulz E, Brodersen HP, Sack K (1983) Verhalten der Harnausscheidung von Tubuluszellen und Malatdehydrogenase in Abhängigkeit von Körpergewicht, Geschlecht und Stamm. J Clin Chem Clin Biochem 21:245–246.
Simane ZJ, Breuer J (1983) Harnenzyme und andere Urinparameter im Tierversuch. J Clin Chem Clin Biochem 21:237–247.
Simane ZJ, Helm W (1984) The output of some urinary enzymes in rat as related to sex and age. Rev Brasil Anal Clin 16:97.
Stonard MD, Gore CW, Oliver GJA, Smith IK (1987) Urinary enzymes and protein patterns as indicators of injury to different regions of the kidney. Fundam Appl Toxicol 9:339–351.
Talesara CL, Mohini L (1978) Age-related changes in the activity of certain enzymes in the kidney of rat. Indian J Exp Biol 16:183–186.
Tate SS, Meister A (1975) Identity of malate-stimulated “glutaminase” with γ-glutamyltranspeptidase in rat kidney. J Biol Chem 250:4619–4624.
Wachsmuth ED (1981) Nephrotoxicity of cefotiam (CGP 14221/E) in rats and rabbits. Arch Toxicol 48:135–138.
Weber MH (1988) Urinary protein analysis. J Chrom 429:315–344.
Zbinden G, Fent K, Thouin MH (1988) Nephrotoxicity screening in rats; general approach and establishment of test criteria. Arch Toxicol 61:344–348.
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© 1992 Springer-Verlag Berlin Heidelberg
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Fuchs, E., Grötsch, H. (1992). Animal Models. In: Jung, K., Mattenheimer, H., Burchardt, U. (eds) Urinary Enzymes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84313-6_16
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DOI: https://doi.org/10.1007/978-3-642-84313-6_16
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-84315-0
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