Abstract
The intestinal epithelial cell (enterocyte) forms an interesting type of polarized cell to study the sorting of endogenous membrane proteins (for reviews see Ginsel et al., 1988; Fransen et al., 1988; and Hauri, 1988). It is characterized by a typical brush border (apical or microvillar) membrane containing hydrolases involved in the terminal digestion of dietary carbohydrates and peptides, and a basolateral membrane with different structural and functional properties. Studies on the pathways and mechanisms of protein sorting in this type of cell have been going on for a relatively long period. The data on the transport pathways were however, controversial. It was unclear whether the brush-border hydrolases are directly transported from the Golgi apparatus to the apical membrane (Danielsen and Cowell, 1985; Fransen et al., 1985) or, indirectly, via the basolateral membrane (Hauri et al., 1979; Massey et al., 1987).
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© 1992 Springer-Verlag Berlin Heidelberg
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Ginsel, L.A., Klumperman, J., Tager, J.M., Fransen, J.A.M. (1992). Sorting of Endogenous Proteins in Intestinal Epithelial Cells. In: Courtoy, P.J. (eds) Endocytosis. NATO ASI Series, vol 62. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84295-5_34
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DOI: https://doi.org/10.1007/978-3-642-84295-5_34
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