Renal Cell Carcinoma

  • Alan C. Winfield
  • W. Scott McDougal
Part of the Medical Radiology book series (MEDRAD)


Renal adenocarcinoma is a disease with protean manifestations involving approximately 15000 individuals in the United States annually. The incidence doubled in males and slightly increased in females over the period from 1930 to 1967. Currently, about 5000–7000 patients die of this disease annually. The incidence of renal adenocarcinoma increases steadily after the age of 30. In men, the tumor is most prevalent in the sixth decade and in women, in the seventh decade. The average age at the time of diagnosis is 57 years. It is rarely found in children, having been reported somewhat less than 100 times in infancy and childhood.


Renal Cell Carcinoma Renal Vein Renal Mass Tumor Thrombus Excretory Urography 
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  1. Balfe DM, McClennan BL, Stanley RJ et al. (1982) Evaluation of renal masses considered indeterminate on computed tomography. Radiology 142:421–428PubMedGoogle Scholar
  2. Bard RH, Lord B, Fromowitz F (1982) Papillary adenocarcinoma of kidney II. Radiographic and biologic characteristics. Urology 19:16–19PubMedCrossRefGoogle Scholar
  3. Basile JJ, McCullough DL, Harrison LH, Dyer RB (1988) End stage renal disease associated with acquired cystic disease and neoplasia. Urology 140:938–943Google Scholar
  4. Bissada NK, Finkbeiner AE, Williams JD et al. (1977) Successful extraction of intracardiac tumor thrombus of renal carcinoma. J Urol 118:474–475PubMedGoogle Scholar
  5. Bosniak MA, Megibow AJ, Hulnick DH et al. (1988) CT diagnosis of renal angiomyolipoma: the importance of detecting small amounts of fat. AJR 151:497–502PubMedGoogle Scholar
  6. Cherrie RJ, Goldman DG, Lindner A, DeKernion JB (1982) Prognostic implications of vena caval extension of renal cell carcinoma. J Urol 128:910–912PubMedGoogle Scholar
  7. Cohen AJ, Li FP, Berg S et al. (1979) Hereditary RCC associated with chromosomal translocation. N Engl J Med 301: 592–595PubMedCrossRefGoogle Scholar
  8. Cronan JJ, Ridlen MS, Dorfman GS et al. (1988) Renal cell carcinoma: Can CT actually stage the IVC? AJR 151: 208Google Scholar
  9. Curry NS, Schabel SI, Betsill WL (1986) Small renal neoplasms : diagnostic imaging, pathologic features and clinical course. Radiology 158:113–117PubMedGoogle Scholar
  10. Davidson AJ (1985) Radiology of the kidney. W.B.Saunders, Philadelphia, pp 329–394Google Scholar
  11. deKernion J (1980) Lymphadenectomy for renal cell carcinoma, therapeutic complications. Urol Clin North Am 7:697–703PubMedGoogle Scholar
  12. Dubbins PA, Wells I (1986) Renal carcinoma: Duplex dropper evaluation. Br J Radiol 59:231–236PubMedCrossRefGoogle Scholar
  13. Duckett JW Jr, Lifland JH, Peters PC (1973) Resection of the inferior vena cava for adjacent malignant diseases. Surg Gynecol Obstet 136:711–716PubMedGoogle Scholar
  14. Elkin M (1980) Radiology of the urinary system. Little, Brown, and Co., Boston, pp 299–327Google Scholar
  15. Falke THM, Peetom JJ, van de Velde CJH et al. (1988) Gadolinium-DTPA enhanced MR imaging of intravenous extension of adrenocortical carcinoma. J Comput Assist Tomogr 12:331–334PubMedCrossRefGoogle Scholar
  16. Fuhrman SA, Lasky LC, Limas C (1982) Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 6:655–663PubMedCrossRefGoogle Scholar
  17. Giuliani L, Gilberti C, Ruggiero LM et al. (1983) Results of radical nephrectomy and extensive lymphadenectomy for renal cell carcinoma. J Urol 130:664–668PubMedGoogle Scholar
  18. Hilton S, Bosniak MA, Megibow AJ (1981) Computed tomographic demonstration of a spontaneous subcapsular hematoma due to a small renal cell carcinoma. Radiology 141: 743–744PubMedGoogle Scholar
  19. Hricak H, Demas B, Williams R et al. (1985) Magnetic resonance imaging in the diagnosis and staging of renal and perirenal neoplasms. Radiology 154:709–715PubMedGoogle Scholar
  20. Johnson CD, Dunnick NR, Cohan RH et al. (1986) Renal adenocarcinoma: CT staging of 100 tumors. AJR 148:59–63Google Scholar
  21. Kearney GP, Waters WB, Klein LA, Richie JP, Gittes RF (1981) Results of inferior vena cava resection for renal cell carcinoma. J Urol 125:769–773PubMedGoogle Scholar
  22. Lang EK (1973) Arteriography in the diagnosis and staging of hypernephromas. Cancer 32:1043–1052PubMedCrossRefGoogle Scholar
  23. Lang EK (1984 a) Angiocomputed tomography and dynamic computed tomography in staging of renal cell carcinoma. Radiology 151:149–155PubMedGoogle Scholar
  24. Lang EK (1984b) Comparison of dynamic and conventional computed tomography, angiography and ultrasonography in the staging of renal cell carcinoma. Cancer 54: 2205–2214PubMedCrossRefGoogle Scholar
  25. Lang EK (1986 a) An algorithmic approach to the diagnosis and staging of renal neoplasms. Interventional uroradiology. W.B.Saunders, Philadelphia, pp 683–694Google Scholar
  26. Lang EK (1986b) Percutaneous and interventional urology and radiology. Springer, Berlin Heidelberg New YorkCrossRefGoogle Scholar
  27. Lang EK (1988) Management of primary and metastatic renal cell carcinoma by transcatheter embolization with I–125. Cancer 62:274–282PubMedCrossRefGoogle Scholar
  28. Levin DC, Gordon D, Kinkhabwala M et al. (1976) Reticular neovascularity in malignant and inflammatory renal masses. Radiology 120:61–66PubMedGoogle Scholar
  29. Levine E, Maklad NF, Rosenthall JJ et al. (1980) Comparison of computed tomography and ultrasound in abdominal staging of renal cancer. Urology 161:317–322CrossRefGoogle Scholar
  30. Libertino JH, Zinman L, Watkins E Jr (1987) Long-term results of resection of renal cell cancer with extension into inferior vena cava. J Urol 137:21–24PubMedGoogle Scholar
  31. Lindner A, Goldman DG, deKernion JB (1983) Cost effective analysis of prenephrectomy radioisotope scans in renal cell carcinoma. Urology 22:127–129PubMedCrossRefGoogle Scholar
  32. McClennan BL, Lee JKT (1982) Kidneys. In: Lee JKT, Sagel SS, Stanley RJ (eds) Computed body tomography. Raven, New YorkGoogle Scholar
  33. McClennan BL, Stanley RJ, Weyman PJ et al. (1979) CT of the renal cyst: Is cyst aspiration necessary? AJR 133: 671–675PubMedGoogle Scholar
  34. Neves RJ, Zincke H (1987) Surgical treatment of renal cancer with vena cava extension. Br J Urol 59:390–395PubMedCrossRefGoogle Scholar
  35. Oberling C, Riviere M, Haguenau F (1960) Ultrastructure of the clear cells in renal carcinoma and its importance for the demonstration of their renal origin. Nature 186:402–403PubMedCrossRefGoogle Scholar
  36. O’Dea MJ, Zincke H, Utz DC, Bernatz PE (1978) The treatment of renal cell carcinoma with solitary metastases. J Urol 120:540–542PubMedGoogle Scholar
  37. Palmer JM (1983) Role of partial nephrectomy in solitary or bilateral renal tumors. JAMA 249:2357–2361PubMedCrossRefGoogle Scholar
  38. Parienty RA, Pradel J, Parienty I (1985) Cystic renal cancers: CT characteristics. Radiology 157:741–744PubMedGoogle Scholar
  39. Patel SK, Stack CM, Turner DA (1987) Magnetic resonance imaging in staging of renal cell carcinoma. Radiographics 7: 703–728PubMedGoogle Scholar
  40. Peters PC, Brown GL (1980) The role of lymphadenectomy in the management of renal cell carcinoma. Urol Clin North Am 7:705–709PubMedGoogle Scholar
  41. Pritchett TR, Lieskovsky G, Skinner DG (1986) Extension of renal cell carcinoma into the vena cava: clinical review and surgical approach. J Urol 135:460–464PubMedGoogle Scholar
  42. Robson CJ (1982) Results of radical thoracoabdominal nephrectomy in the treatment of renal cell carcinoma. In: Kuss R, Murphy GP, Khoury S, Karr JP (eds) Renal tumors: proceedings of the first international symposium on kidney tumors. Alan R. Liss, New York, p 481Google Scholar
  43. Rubin AL, Cheigh JS, Stenzel KH (1975) Symposium on endocrine functions of the kidney. Foreword. Am J Med 58:1PubMedCrossRefGoogle Scholar
  44. Skinner DG, Pfister RF, Colvin R (1972) Extension of renal cell carcinoma into the vena cava; the rationale for aggressive surgical management. J Urol 107:711–716PubMedGoogle Scholar
  45. Sudeck P (1893) Zwei Fälle von Adenosarcom der Niere. Virchows Arch [A] 133: 558–562Google Scholar
  46. Tobia BM, Whitmore WF Jr (1975) Solitary metastases from renal cell carcinoma. J Urol 114: 836–838Google Scholar
  47. Wallace AC, Nairn RC (1972) Renal tubular antigens in kidney tumors. Cancer 29:977–981PubMedCrossRefGoogle Scholar
  48. Waters WB, Richie JP (1979) Aggressive surgical approach to renal cell carcinoma: review of 130 cases. J Urol 122: 306–309PubMedGoogle Scholar
  49. Weyman PJ, McClennan BL, Stanley RJ et al. (1980) Comparison of computed tomography and angiography in the evaluation of renal cell carcinoma. Radiology 137:417–424PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Alan C. Winfield
    • 1
  • W. Scott McDougal
    • 2
  1. 1.Department of Radiology and Radiological SciencesVanderbilt University School of MedicineNashvilleUSA
  2. 2.Department of UrologyVanderbilt University School of MedicineNashvilleUSA

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