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Treatment of Advanced Carcinoma of the Bladder with Concomitant 5-Fluorouracil Infusion and Radiation

  • Chapter
Concomitant Continuous Infusion Chemotherapy and Radiation

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

It is estimated that in the United States during 1989, a total of 47100 patients will be diagnosed with bladder carcinoma (Silowberg and Lubera 1989). During this same year, a sizeable number of patients (approximately 10200) are expected to die from this disease. Unfortunately, despite recent advances in surgical and radiotherapeutic techniques, the percentage of patients dying from this disease has not changed since 1930. For superficial bladder carcinomas (stage 0, A, B1), acceptable locoregional control rates and 5-year survivals have been obtained with transurethral resection of the bladder, partial cystectomy, interstitial implants, and intravesicular chemotherapy. With deeply infiltrating tumors, a high incidence of lymphatic involvement significantly worsens the prognosis, whatever treatment modality is attempted. In the best reported series, surgery or definitive radiotherapy for invasive bladder carcinoma achieved only a 25%-30% survival rate (Pearse et al. 1978; Prout 1976; Richie et al. 1975).

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Author information

Authors and Affiliations

  1. Radiation Oncology, SUNY-Health Science Center at Brooklyn, 450 Clarkson Avenue, Brooklyn, NY, 11203, USA

    Marvin Rotman MD (Professor and Chairman), Hassan Aziz MD (Associate Professor), Louis Potters MD & Kwang Choi MD (Associate Professor)

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  1. Marvin Rotman MD
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  2. Hassan Aziz MD
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  3. Louis Potters MD
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  4. Kwang Choi MD
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Editors and Affiliations

  1. SUNY Health Science Center at Brooklyn, State University of New York, 450 Clarkson Ave., Box 1211, Brooklyn, 11203-2098, USA

    Marvin Rotman MD (Professor and Chairman, Dept. of Radiation Oncology) & C. Julian Rosenthal MD (Professor of Medicine and Oncology) (Professor and Chairman, Dept. of Radiation Oncology) &  (Professor of Medicine and Oncology)

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© 1991 Springer-Verlag Berlin Heidelberg

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Rotman, M., Aziz, H., Potters, L., Choi, K. (1991). Treatment of Advanced Carcinoma of the Bladder with Concomitant 5-Fluorouracil Infusion and Radiation. In: Rotman, M., Rosenthal, C.J. (eds) Concomitant Continuous Infusion Chemotherapy and Radiation. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84186-6_20

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  • DOI: https://doi.org/10.1007/978-3-642-84186-6_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84188-0

  • Online ISBN: 978-3-642-84186-6

  • eBook Packages: Springer Book Archive

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